Effects of monthly intravenous ibandronate on bone mineral density and microstructure in patients with primary osteoporosis after teriparatide treatment: The MONUMENT study

Chiba, Ko; Yamada, Shuta; Yoda, Itaru; Era, Makoto; Yokota, Kazuaki; Okazaki, Narihiro; Ota, Shingo; Isobe, Yusaku; Miyazaki, Satsuki; Tashiro, Shohei; Nakashima, Sawako; Morimoto, Shimpei; Sato, Shuntaro; Tsukazaki, Tomoo; Watanabe, Takehiko; Enomoto, Hiroshi; Yabe, Yoshihiro; Yonekura, Akihiko; Tomita, Masato; Ito, Masako; Osaki, Makoto

doi:10.1016/j.bone.2020.115770

Cited by 6 publications

(6 citation statements)

References 42 publications

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“…The last imaging was performed one year after the first acquisition, which could lead to a selectional bias. Bone microarchitecture changes over time, e.g., due to illnesses and medication or changes in repetitive mechanical stress on the wrist joint (11)(12)(13)31,35). Kawalilak et al (31) showed significant changes in the microarchitecture of the distal radius in postmenopausal women within one year.…”

Section: Discussionmentioning

confidence: 99%

“…Its clinical value is remaining still marginal due to several reasons, including technical issues, a lack of standardization in scan acquisition and evaluation, and it's cost-related limited availability (10). However, in recent years HR-pQCT has made significant progress in many scientific fields, e.g., in the assessment of the influence of rheumatologic diseases on joint surfaces (11,12), of bone microarchitecture and bone strength in secondary osteoporosis and metabolic bone disorders (10), the effect of several anti-osteoporotic drugs on bone quality (13) as well as in the evaluation of fracture healing (14)(15)(16) and research on fracture mechanisms of the distal radius (17,18).…”

Section: Introductionmentioning

confidence: 99%

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The impact of motion induced artifacts in the evaluation of HR-pQCT scans of the scaphoid bone: an assessment of inter- and intraobserver variability and quantitative parameters

Benedikt¹,

Horling²,

Stock³

et al. 2023

Quant Imaging Med Surg

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Background: In-vivo high-resolution peripheral quantitative computed tomography (HR-pQCT) has high potential in scaphoid bone pathologies' scientific and clinical fields. The manufacturer's visual grading scale (VGS) classifies motion artifacts and divides scans into five quality grades ranging from grade 1 (good quality) to grade 5 (poor quality). This prospective study aimed to investigate the feasibility of the VGS and the influence of image quality on bone density and microarchitecture parameters for the scaphoid bone.Methods: Within one year, twenty-two patients with scaphoid fractures received up to six scans of their fractured and contralateral wrist (each consisting of three stacks) using second-generation HR-pQCT (total 256 scans). Three experienced observers graded each stack following the visual grading system, and interand intraobserver variability were assessed. The contralateral uninjured scaphoids were then compared pairwise within each patient to high-quality grade 1 scans to determine the influence of image quality on density and microarchitecture parameters.Results: Inter-and intraobserver variability among the three observers significantly revealed fair to moderate agreement, P<0.001 and P<0.05, respectively. Bone volume (BV) fraction tended to increase with poorer image quality but did not exceed four percent. Trabecular bone mineral density (Tb.BMD) decreased with poorer image quality but did not exceed five percent. Trabecular number and trabecular thickness significantly increased by 15.5% and 6.8% at grade five (P<0.001), respectively, and trabecular separation significantly decreased by 13.7% at grade five (P<0.001).Conclusions: This study revealed a considerable influence of motion on bone morphometry parameters of the scaphoid. Therefore, high image quality must be a central point in studies focusing on the histomorphometry of small objects. The high inter-and intraobserver variability limit the VGS. Future research may focus on other grading systems or automated techniques leading to more consistent and reproducible results. Currently, the use of microarchitectural analysis should be limited to cases without motion artefacts or, at most low graded motion artefacts.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The impact of motion induced artifacts in the evaluation of HR-pQCT scans of the scaphoid bone: an assessment of inter- and intraobserver variability and quantitative parameters

Benedikt¹,

Horling²,

Stock³

et al. 2023

Quant Imaging Med Surg

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“…Most studies describing BR are based on QCT data. A higher BR is associated with increased fracture risk [ 39 , 40 ] and treatment with osteoporosis medication can improve the BR [ 41 , 42 ]. Increased BRs compared with healthy controls have been described in dialysis patients [ 43 ] and after kidney transplantation [ 44 ].…”

Section: Evaluation Of Fracture Riskmentioning

confidence: 99%

Management of fracture risk in CKD—traditional and novel approaches

Haarhaus

Aaltonen

Cejka

et al. 2022

Clinical Kidney Journal

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The coexistence of osteoporosis and chronic kidney disease (CKD) is an evolving health care challenge in the face of increasingly aging populations. Globally, accelerating fracture incidence causes disability, impaired quality of life, and increased mortality. Consequently, several novel diagnostic and therapeutic tools have been introduced for treatment and prevention of fragility fractures. Despite an especially high fracture risk in CKD, these patients are commonly excluded from interventional trials and clinical guidelines. While management of fracture risk in CKD has been discussed in recent opinion-based reviews and consensus papers in the nephrology literature, many patients with CKD stages 3–5D and osteoporosis are still underdiagnosed and untreated. The current review addresses this potential treatment nihilism by discussing established and novel approaches to diagnosis and prevention of fracture risk in patients with CKD stages 3–5D. Skeletal disorders are common in CKD. A wide variety of underlying pathophysiological processes have been identified, including premature aging, chronic wasting, and disturbances in vitamin D and mineral metabolism, which may impact bone fragility beyond established osteoporosis. We discuss current and emerging concepts of CKD—mineral and bone disorders (CKD-MBD) and integrate management of osteoporosis in CKD with current recommendations for management of CKD-MBD. While many diagnostic and therapeutic approaches to osteoporosis can be applied to patients with CKD, some limitations and caveats need to be considered. Consequently, clinical trials are needed that specifically study fracture prevention strategies in patients with CKD stages 3–5D.

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“…It is di cult to know until a fracture occurs, leading to serious secondary problems of health, and even death [3,4]. Various agents, including hormones (estrogen, calcitonin, and teriparatide) [5][6][7], selective estrogen receptor modulators (raloxifene and bazedoxifene) [8,9], and bisphosphonates (alendronate, ibandronate, and zoledronate) [10,11], have been studied for the treatment of osteoporosis. Among these agents, alendronate (Alen) is one of the bisphosphonates that have selective bone adsorption properties, preventing bone resorption by inhibiting osteoclastic activity, and one that is widely used in the treatment of osteoporosis [12,13].…”

Section: Introductionmentioning

confidence: 99%

Enhanced Osteogenic Differentiation of Alendronate-Conjugated Nanodiamonds for Potential Osteoporosis Treatment

Ahn

Kim

Yun

et al. 2021

Preprint

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Background: Alendronate (Alen) is promising material used for bone-targeted drug delivery due to its high bone affinity and therapeutic effects on bone diseases. In addition, Alen can enhance the osteogenic differentiation of osteoblastic cell. Recently, nanodiamonds (NDs) with hardness, non-toxicity, and excellent biocompatibility are employed as promising materials for carrier systems and osteogenic differentiation. Therefore, we prepared Alen-conjugated NDs (Alen-NDs) and evaluated their osteogenic differentiation performances. Methods: Alen-NDs were synthesized using DMTMM as a coupling reagent. Morphological change of Mouse calvaria-derived preosteoblast (MC3T3-E1) treated with Alen-NDs was observed using the confocal microscope. The osteogenic differentiation was confirmed by cell proliferation, alkaline phosphatase (ALP), calcium deposition, and real-time polymerase chain reaction assay. Results: Alen-NDs were prepared to evaluate their effect on the proliferation and differentiation of osteoblastic MC3T3-E1 cells. The Alen-NDs had a size of about 100 nm, and no cytotoxicity at less than 100 μg/mL of concentration. The treatment of NDs and Alen-NDs reduced the proliferation rate of MC3T3-E1 cells without cell death. Confocal microscopy images confirmed that the treatment of NDs and Alen-NDs changed the cellular morphology from a fibroblastic shape to a cuboidal shape. Flow cytometry, alkaline phosphatase (ALP) activity, calcium deposition, and real-time polymerase chain reaction (RT-PCR) confirmed the higher differentiation of MC3T3-E1 cells treated by Alen-NDs, compared to the groups treated by osteogenic medium and NDs. The higher concentration of Alen-ND treated in MC3T3-E1 resulted in a higher differentiation level. Conclusions: Alen-NDs can be used as potential therapeutic agents for osteoporosis treatment by inducing osteogenic differentiation.

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Effects of monthly intravenous ibandronate on bone mineral density and microstructure in patients with primary osteoporosis after teriparatide treatment: The MONUMENT study

Cited by 6 publications

References 42 publications

The impact of motion induced artifacts in the evaluation of HR-pQCT scans of the scaphoid bone: an assessment of inter- and intraobserver variability and quantitative parameters

The impact of motion induced artifacts in the evaluation of HR-pQCT scans of the scaphoid bone: an assessment of inter- and intraobserver variability and quantitative parameters

Management of fracture risk in CKD—traditional and novel approaches

Enhanced Osteogenic Differentiation of Alendronate-Conjugated Nanodiamonds for Potential Osteoporosis Treatment

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