Effects of Monensin and Stage of Lactation on Variation of Blood Metabolites Within Twenty-Four Hours in Dairy Cows

Abstract

Effects of prepartum administration of a monensin controlled release capsule (CRC) and stage of lactation on variation of blood metabolites within 24 h were determined in 16 dairy cows. Cows were fed a total mixed ration ad libitum twice daily at 0700 and 1300 h. At calving, cows were switched from a close-up dry cow diet to a lactating cow diet. Cows were blood sampled every 3 h for 24 h at 3 stages of lactation, including 1 wk before calving (wk -1), 1 wk after calving (wk 1), and 6 wk after calving (wk 6). Serum concentrations of glucose, beta-hydroxybutyrate (BHBA), nonesterified fatty acids (NEFA), and urea exhibited significant variation within 24 h. Glucose and NEFA were, respectively, 0.09 and 0.08 mM lower between 1030 and 2230 h than between 2230 and 1030 h. beta-Hydroxybutyrate and urea were, respectively, 95.1 and 0.49 mM higher between 1030 and 2230 h than between 2230 and 1030 h. Monensin did not significantly affect glucose, NEFA, and urea in this study. Monensin reduced BHBA at wk 1, but not at wk -1 or wk 6. Glucose was lower and BHBA and NEFA were higher at wk 1 compared with wk -1 and wk 6. Urea was higher at wk 6 compared with wk -1. The variation within 24 h of glucose, BHBA, and NEFA were not affected by monensin and stage of lactation. Diurnal variation of urea was affected by stage of lactation, but not by monensin.

Effect of virginiamycin and monensin supplementation on performance of multiparous Holstein cows

“…Similar prepartum glucose values were reported in the studies of Stephenson et al (1997) and Plaizier et al (2005). Monensin supplementation to prepartum dairy cows increased blood glucose concentration postpartum (Duffield et al, 1998;Green et al, 1999), but not prepartum (Stephenson et al, 1997;Green et al, 1999) which is in agreement with our study (treatment M).…”

Effects of propylene glycol drenching before and after luteolysis on blood glucose, ovarian steroids and follicular dynamics in heifers

“…In this study, the analysis of daily changes in blood glucose supports the latter studies, and that of blood glucose concentration in samples collected at 6-h intervals supports the former studies. Daily fluctuation of blood glucose concentration was observed in lactating cows (Plaizier et al, 2005), whereas its variation seemed to be smaller than those of the present results. This study showed clear daily fluctuations in the blood glucose concentration at 24-h intervals in heifers regardless of the treatment, and significant increases in the blood glucose concentration were only observed until 72 h after the propylene glycol administration with frequent blood sampling analysis.…”

Efeito Da Monensina Sódica Sobre O Perfil Metabólico De Ovelhas Antes E Após O Parto

“…Estes achados se assemelham aos relatados por Abe et al (23) , Duffield et al (25) , Plaizier et al (35) , que analisaram o emprego da monensina em vacas durante o período de transição, por Taghipoor et al (10) em ovelhas no período do pré-parto e Sadjadian et al (28) em cabras de leite no período do periparto. Esta discreta alteração no perfil glicêmico, influenciada pela monensina, neste período, poderá ser justificada pelo maior estímulo na produção de insulina, provocado pelo aumento no fluxo glicogênico, que resultaria na diminuição nos valores de glicose plasmática nos animais tratados com o ionóforo, provavelmente pela maior participação da glicose no crescimento dos fetos, que é mais expressiva nesta fase da gestação (24) .…”