Effects of Molsidomine on Retinopathy and Oxidative Stress Induced by Radiotheraphy in Rat Eyes

Özer, Murat Atabey; Polat, Nihat; Özen, Serkan; Parlakpınar, Hakan; Ekici, Kemal; Polat, Alaaddin; Vardı, Nigar; Tanbek, Kevser; Yıldız, Azibe

doi:10.1080/02713683.2016.1238943

Cited by 15 publications

(14 citation statements)

References 30 publications

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“…Indeed, studies have shown that oxidative stress in the degenerating retinas is considerably higher than that of normal retinas. Apart from retinal degeneration, oxidative damage is also a key pathology of many other diseases, such as age-related macular degeneration, glaucoma, diabetic retinopathy (31), retinopathy of prematurity (30), dry eye syndrome (32), keratitis (33), and retinopathy after radiotherapy (34). Different antioxidants have been used in the clinic to treat patients with degenerative diseases (35).…”

Section: Discussionmentioning

confidence: 99%

VEGF-B is a potent antioxidant

Arjunan

Lin²,

Tang³

et al. 2018

Proc. Natl. Acad. Sci. U.S.A.

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VEGF-B was discovered a long time ago. However, unlike VEGF-A, whose function has been extensively studied, the function of VEGF-B and the mechanisms involved still remain poorly understood. Notwithstanding, drugs that inhibit VEGF-B and other VEGF family members have been used to treat patients with neovascular diseases. It is therefore critical to have a better understanding of VEGF-B function and the underlying mechanisms. Here, using comprehensive methods and models, we have identified VEGF-B as a potent antioxidant. Loss of Vegf-b by gene deletion leads to retinal degeneration in mice, and treatment with VEGF-B rescues retinal cells from death in a retinitis pigmentosa model. Mechanistically, we demonstrate that VEGF-B up-regulates numerous key antioxidative genes, particularly, Gpx1. Loss of Gpx1 activity largely diminished the antioxidative effect of VEGF-B, demonstrating that Gpx1 is at least one of the critical downstream effectors of VEGF-B. In addition, we found that the antioxidant function of VEGF-B is mediated mainly by VEGFR1. Given that oxidative stress is a crucial factor in numerous human diseases, VEGF-B may have therapeutic value for the treatment of such diseases.

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Section: Discussionmentioning

confidence: 99%

VEGF-B is a potent antioxidant

Arjunan

Lin²,

Tang³

et al. 2018

Proc. Natl. Acad. Sci. U.S.A.

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“…or decreased antioxidant capacity (caused by malnutrition or aging, etc.) leads to oxidant/antioxidant imbalances in vivo [36][37][38][39]. Oxidative stress generated by oxidant/antioxidant imbalances results in cell damage and dysfunction.…”

Section: Molecular Aspects Of Oxidative Stress-induced Cell Damagementioning

confidence: 99%

“…Intraocular surgery includes cataract surgery [103], beta radiation therapy [104], and laser posterior capsulotomy [105]. It has been reported that intraocular surgery causes a significant decrease in ECD, which is possibly related to the oxidative stress that surgery causes [37][38][39]. Decreased ECD is a significant cause of the loss of function in transplanted corneas, and ECD can predict the success of corneal transplantations [106][107][108].…”

Section: Others (Oxidative Stress-related Surgical Complications)mentioning

confidence: 99%

The Pathomechanism, Antioxidant Biomarkers, and Treatment of Oxidative Stress-Related Eye Diseases

Hsueh

Chen

Tsao

et al. 2022

IJMS

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Oxidative stress is an important pathomechanism found in numerous ocular degenerative diseases. To provide a better understanding of the mechanism and treatment of oxidant/antioxidant imbalance-induced ocular diseases, this article summarizes and provides updates on the relevant research. We review the oxidative damage (e.g., lipid peroxidation, DNA lesions, autophagy, and apoptosis) that occurs in different areas of the eye (e.g., cornea, anterior chamber, lens, retina, and optic nerve). We then introduce the antioxidant mechanisms present in the eye, as well as the ocular diseases that occur as a result of antioxidant imbalances (e.g., keratoconus, cataracts, age-related macular degeneration, and glaucoma), the relevant antioxidant biomarkers, and the potential of predictive diagnostics. Finally, we discuss natural antioxidant therapies for oxidative stress-related ocular diseases.

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“…It can be used to treat the eye tissue damage caused due to ionizing radiation. 13 , 14 , 15 Until now, there are no data of molsidomine acting against diabetic peripheral neuropathy. Therefore, the present study was designed to evaluate the protective effect of molsidomine against diabetic peripheral neuropathy.…”

Section: Introductionmentioning

confidence: 99%

Molsidomine ameliorates diabetic peripheral neuropathy complications in Wistar rats

Nayak

Minaz

Pasha

2021

Anim Models and Exp Med

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Diabetes mellitus (DM) prevalence is increasing at an alarming rate as it was 381 million people globally in 2013 and is estimated to be 463 million people in 2019 rising to 578 million by 2030. It is a disease with high rate of complications such as neuropathy, nephropathy, retinopathy, erectile dysfunction etc. 1,2 Diabetic neuropathy is a family of disorders that damage the different regions of the nervous system, either individually or in combination. It affects pain fibres, motor neurons and autonomic nervous system. 3 It results in large economic costs for its care. [4][5][6] The various kind of neuropathies include peripheral neuropathy, proximal neuropathy, autonomic neuropathy and focal neuropathy. 7 There are a number of reasons for the pathogenesis of diabetic neuropathy and polyol pathway of glucose metabolism is thought as one of the major mechanism. 8 Peripheral neuropathy is a type of nerve damage that usually affects feet and legs and sometimes hands and arms. 9 It is proved that reactive oxygen species (ROS) plays a significant role in the pathophysiology of neuropathic pain in diabetes. 10 Out of all diabetic patients, 50% of patients develop neuropathy and painful neuropathy ranges from 10% to 20% in patients with diabetes. Diabetic patients can experience nerve problems at any time and the problem increases with age, weight and duration. 5 The complications across various countries varies from 10% to 30% and it is higher in developed countries than in developing countries. These complications can lead to painful symptoms and can affect quality of life of the patient. The treatment for the painful diabetic

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Effects of Molsidomine on Retinopathy and Oxidative Stress Induced by Radiotheraphy in Rat Eyes

Abstract: We suggest that MOL is a powerful antioxidant and free radical scavenger that prevents the rat eyes from radiation-induced retinopathy and oxidative stress.

Cited by 15 publications

References 30 publications

VEGF-B is a potent antioxidant

VEGF-B is a potent antioxidant

The Pathomechanism, Antioxidant Biomarkers, and Treatment of Oxidative Stress-Related Eye Diseases

Molsidomine ameliorates diabetic peripheral neuropathy complications in Wistar rats

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