Effects of molecular weight of chitosan on anti-inflammatory activity and modulation of intestinal microflora in an ulcerative colitis model

Niu, Wei; Dong, Yuelin; Fu, Ziwei; Lv, Jiajie; Wang, Ligui; Zhang, Zhenhai; Huo, Jiege; Ju, Jianming

doi:10.1016/j.ijbiomac.2021.11.024

Cited by 25 publications

(14 citation statements)

References 90 publications

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“…62 In line with these findings, an increase of Prevotellaceae in the intestine was also found to be associated with an antiinflammatory and protective action of chitin oligosaccharides in a mouse model of ulcerative colitis. 23…”

Section: Discussionmentioning

confidence: 99%

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Feeding of cuticles from Tenebrio molitor larvae modulates the gut microbiota and attenuates hepatic steatosis in obese Zucker rats

et al. 2022

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Section: Discussionmentioning

confidence: 99%

“…), 21 and improves the intestinal barrier function. 22 In addition, chitin oligosaccharides were reported to reduce inflammation and oxidative stress in a mouse model of colitis ulcerosa, 23 and to promote faecal excretion of lipids, i.e. , cholesterol and bile acids, in diet-induced obese rats.…”

Section: Introductionmentioning

confidence: 99%

Feeding of cuticles from Tenebrio molitor larvae modulates the gut microbiota and attenuates hepatic steatosis in obese Zucker rats

et al. 2022

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“…Several researchers observed the discrepancy in antibacterial activity, and it was postulated that high-molecularweight chitosan cannot pass through the microbial membrane, meaning it accumulates on the cell surface, which alters the cell permeability by blocking nutrient transport and results in cell lysis [83][84][85][86]. Dissociated chitosan molecules in solution with a smaller molecular weight may, on the other hand, bind to DNA and suppress mRNA production by penetrating the nucleus of bacteria [87][88][89][90].…”

Section: Molecular Weightmentioning

confidence: 99%

Electrospinning of Chitosan for Antibacterial Applications—Current Trends

2021

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Chitosan is a natural biopolymer that can be suitable for a wide range of applications due to its biocompatibility, rigid structure, and biodegradability. Moreover, it has been proven to have an antibacterial effect against several bacteria strains by incorporating the advantages of the electrospinning technique, with which tailored nanofibrous scaffolds can be produced. A literature search is conducted in this review regarding the antibacterial effectiveness of chitosan-based nanofibers in the filtration, biomedicine, and food protection industries. The results are promising in terms of research into sustainable materials. This review focuses on the electrospinning of chitosan for antibacterial applications and shows current trends in this field. In addition, various aspects such as the parameters affecting the antibacterial properties of chitosan are presented, and the application areas of electrospun chitosan nanofibers in the fields of air and water filtration, food storage, wound treatment, and tissue engineering are discussed in more detail.

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“…The anti-inflammatory effect of chitosan against IBD and UC has been reported in previous studies [ 59 ] where high-molecular-weight chitosan had better therapeutic effects in UC compared with-low molecular-weight chitosan [ 60 ]. On the other hand, an increase in the molecular weight of chitosan could result in a decline in the drug release which could be due to the greater viscosity of the gel layer created around the drug particles upon contact with the dissolution medium [ 61 , 62 ].…”

Section: Resultsmentioning

confidence: 79%

Preparation and Characterization of a Novel Multiparticulate Dosage Form Carrying Budesonide-Loaded Chitosan Nanoparticles to Enhance the Efficiency of Pellets in the Colon

et al. 2022

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An attempt was made to conquer the limitation of orally administered nanoparticles for the delivery of budesonide to the colon. The ionic gelation technique was used to load budesonide on chitosan nanoparticles. The nanoparticles were investigated in terms of size, zeta potential, encapsulation efficiency, shape and drug release. Then, nanoparticles were pelletized using the extrusion–spheronization method and were investigated for their size, mechanical properties, and drug release. Pellets were subsequently coated with a polymeric solution composed of two enteric (eudragit L and S) and time-dependent polymers (eudragit RS) for colon-specific delivery. All formulations were examined for their anti-inflammatory effect in rats with induced colitis and the relapse of the colitis after discontinuation of treatment was also followed. The size of nanoparticles ranged between 288 ± 7.5 and 566 ± 7.7 nm and zeta potential verified their positive charged surface. The drug release from nanoparticles showed an initial burst release followed by a continuous release. Pelletized nanoparticles showed proper mechanical properties and faster drug release in acidic pH compared with alkaline pH. It was interesting to note that pelletized budesonide nanoparticles released the drug throughout the GIT in a sustained fashion, and had long-lasting anti-inflammatory effects while rapid relapse was observed for those treated with conventional budesonide pellets. It seems that there is a synergistic effect of nanoformulation of budesonide and the encapsulation of pelletized nanoparticles in a proper coating system for colon delivery that could result in a significant and long-lasting anti-inflammatory effect.

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Effects of molecular weight of chitosan on anti-inflammatory activity and modulation of intestinal microflora in an ulcerative colitis model

Cited by 25 publications

References 90 publications

Feeding of cuticles from Tenebrio molitor larvae modulates the gut microbiota and attenuates hepatic steatosis in obese Zucker rats

Feeding of cuticles from Tenebrio molitor larvae modulates the gut microbiota and attenuates hepatic steatosis in obese Zucker rats

Electrospinning of Chitosan for Antibacterial Applications—Current Trends

Preparation and Characterization of a Novel Multiparticulate Dosage Form Carrying Budesonide-Loaded Chitosan Nanoparticles to Enhance the Efficiency of Pellets in the Colon

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