Effects of Molecular Weight and Guluronic Acid/Mannuronic Acid Ratio on the Rheological Behavior and Stabilizing Property of Sodium Alginate

Jiao, Wenxiao; Chen, Wenxue; Mei, Yuqi; Yun, Yong‐Huan; Wang, Boqiang; Zhong, Qiuping; Chen, Haiming

doi:10.3390/molecules24234374

Cited by 89 publications

(45 citation statements)

References 33 publications

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“…The alginate dressings with high mannuronic acid content gel rapidly and are therefore called rapid gelling fiber dressings. 48 Alginates are suitable for highly exud-ing wounds. 15,[44][45][46] Examples of alginate wound dressings include Algisite ) and Kaltostat Ò .…”

Section: Moist Dressingsmentioning

confidence: 99%

Moist Wound Healing with Commonly Available Dressings

Nuutila

Eriksson

2021

Advances in Wound Care

197

110

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Significance: A moist wound environment has several benefits that result in faster and better quality of healing. It facilitates autolytic debridement, reduces pain, reduces scarring, activates collagen synthesis, facilitates and promotes keratinocyte migration over the wound surface, and supports the presence and function of nutrients, growth factors, and other soluble mediators in the wound microenvironment. Recent Advances: Wound dressings can be utilized to create, maintain, and control a moist environment for healing. Moist wound dressings can be divided into films, foams, hydrocolloids, hydrogels, and alginates. We are also including negative pressure wound therapy systems in the moist dressings. Critical Issues: An optimal wound dressing should provide a moist environment and have an optimal water vapor transmission rate (WVTR) and absorptive capacity. It should also protect the wound against trauma and contamination and be easy to apply, painless to remove, and esthetically acceptable or even pleasing. Future Directions: Interventions, particularly dressing changes, by medical caregivers are labor intensive and expensive and there should be a continuous effort to reduce their number per week. Smart dressings with integrated microsensors and delivery capabilities that would allow wireless real-time monitoring and treatment of the wound would be very advantageous. This way the state of the wound as well as the wear time of the dressing could be assessed without dressing removal or visit to the wound care center. In addition, an ability to adjust the WVTRs to the exudate level of the wound (or having a large absorptive capacity without changing the WVTR) would be useful. This feature would guarantee an optimal level of hydration of the wound surface throughout the treatment.

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Section: Moist Dressingsmentioning

confidence: 99%

Moist Wound Healing with Commonly Available Dressings

Nuutila

Eriksson

2021

Advances in Wound Care

197

110

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“…The spectrum also showed peaks for C, O, and Ca, which could be explained by the composition of the algal beads. Alginate is one of the main components in algal beads which consists of β‐D‐mannuronic acid and α‐L‐guluronic acid units, which are rich in C and O (Jiao et al, 2019). CaCl 2 was used in preparation of algal beads as the hardening material, and it explains the presence of Ca ions on the surface of the beads.…”

Section: Resultsmentioning

confidence: 99%

Immobilized algae‐based treatment of herbicide‐contaminated groundwater

Mollamohammada

Hassan

Dahab

2020

Water Environment Research

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Scenedesmus species, immobilized on alginate gel, was found effective in removing nitrate, atrazine, magnesium, phosphorus, zinc, oxadiazon, and triallate from groundwater in a continuous flow reactor. The laboratory‐scale experiments with synthetic groundwater, made of 8.8 mg/L NO3‐N and 90 µg/L atrazine, were performed at a hydraulic retention time of 7 days and the temperatures of 20 and 35°C. The highest uptake of nitrate and atrazine was observed at 20°C (97% and 70%, respectively). When tested in actual groundwater, 92% of nitrate, 100% of magnesium, 99.9% of phosphorus, and 92% of zinc were successfully removed at the end of 29 days’ treatment operations. The algal beads removed 100% of oxadiazon and triallate in the first 10 days, but some of the herbicides diffused back into the solution toward the end of the treatment process. Practitioner points Immobilized algae–alginate beads can remove nitrate, atrazine, oxadiazon, and triallate from groundwater in continuous flow reactor. The uptake rate of nitrate and atrazine is higher in room temperature (20°C). Same algae beads could be reused for herbicide uptake for the average of 10 days. The immobilized system is a natural sustainable alternative that can be used in groundwater pump and treat.

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“…no. A1112-100G, low viscosity, 4–12 cP, 1% in H 2 O (25 °C), mannuronate and gluronate ratio (M/G ratio), St. Louis, MO, USA) falling in the range of 6.07–6.18 ± 0.04–0.06, estimated from the cited reference) [ 15 ]. Calcium chloride anhydrous (99%, J.T.…”

Section: Methodsmentioning

confidence: 99%

Plate-like Alginate Microparticles with Disulfiram–SPIO–Coencapsulation: An In Vivo Study for Combined Therapy on Ovarian Cancer

Bai

Wang

et al. 2021

Pharmaceutics

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Disulfiram is a drug used to support the treatment of chronic alcoholism. Recently, it has been found to have an off-label ability to inhibit the growth of ovarian cancer cells. However, the original formulation was designed for use via oral administration, which is not suitable to be given by a direct spray on the affected area. Therefore, in this study, we designed and prepared alginate (ALG) microparticles loaded with disulfiram and superparamagnetic iron oxide (cross-linking disulfiram/SPIO/ALG MPs), which have great potential application for inhibiting the growth of ovarian cancer simultaneously via two treatments, i.e., chemotherapy and hyperthermia. The drug-encapsulating alginate microparticles were prepared using an electrospray system and then cross-linked with calcium chloride ions. The particles were observed by optical microscopy and scanning electron microscopy, and found to be approximately 200 μm in diameter. The disc-shape morphology of the microparticles could be controlled by up to 95%. The drug-encapsulation efficiency of the microparticles reached 98%, and the suppression of tumor growth for the free-form disulfiram-treated group and disulfiram/SPIO/ALG MPs-treated group were 48.2% and 55.9% of tumor volume reduction, respectively, compared with a cisplatin-treated group. A hyperthermic effect can be achieved by applying a magnetic field to oscillate SPIO. The results of this study showed that these cross-linking disulfiram/SPIO/ALG MPs are potential drug carriers for the treatment of ovarian cancer.

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Effects of Molecular Weight and Guluronic Acid/Mannuronic Acid Ratio on the Rheological Behavior and Stabilizing Property of Sodium Alginate

Cited by 89 publications

References 33 publications

Moist Wound Healing with Commonly Available Dressings

Moist Wound Healing with Commonly Available Dressings

Immobilized algae‐based treatment of herbicide‐contaminated groundwater

Plate-like Alginate Microparticles with Disulfiram–SPIO–Coencapsulation: An In Vivo Study for Combined Therapy on Ovarian Cancer

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