Effects of molasses interacting with formic acid on the fermentation characteristics, proteolysis and microbial community of seed-used pumpkin leaves silage

Song, Chunsheng; Li, Jiawei; Xing, Jinxu; Wang, Cheng; Li, Jianping; Shan, Anshan

doi:10.1016/j.jclepro.2022.135186

Cited by 6 publications

(1 citation statement)

References 40 publications

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“…WL-C 8 is more efficient in the presence of various salts, but its application is restricted by its toxicity toward mammalian cells. Proteases are widely found in plants, animal, and microorganisms (Song et al, 2022;Li et al, 2022a). Tryptase/chymase is widely distributed in human body tissues such the bronchus, skin, and cardiovascular system and has a functional structure that is comparable to that of trypsin/ chymotrypsin (Irani and Schwartz, 1994;Miller and Pemberton, 2002).…”

Section: Stability and Bactericidal Kinetics Of The Lipidated Peptidesmentioning

confidence: 99%

Designing double-site lipidated peptide amphiphiles as potent antimicrobial biomaterials to combat multidrug-resistant bacteria

et al. 2022

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Rapidly evolving antimicrobial resistance and extremely slow development of new antibiotics have resulted in multidrug-resistant bacterial infections that present a serious threat to human health. Antimicrobial peptides (AMPs) provide promising substitutes, but more research is needed to address several of their present limitations, such as insufficient antimicrobial potency, high toxicity, and low stability. Here, we designed a series of novel double-site lipidated peptide amphiphiles based on a heptad repeat parent pentadecapeptide. The double-site lipidated peptide amphiphiles showed a broad spectrum of antimicrobial activities. Especially the double-site lipidated peptide amphiphile WL-C6 exhibited high potency to inhibit multidrug-resistant bacteria without significant toxicity toward mammalian cells. Furthermore, even at physiological salt ion concentrations, WL-C6 still exhibited outstanding antibacterial properties, and a sizeable fraction of it maintained its molecular integrity after being incubated with different proteases. Additionally, we captured the entire process of WL-C6 killing bacteria and showed that the rapid bacterial membrane disruption is the reason of bacterial death. Overall, WL-C6 shows great promise as a substitute for conventional antibiotics to combat the growing threat of multidrug-resistant bacterial infections.

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Section: Stability and Bactericidal Kinetics Of The Lipidated Peptidesmentioning

confidence: 99%

Designing double-site lipidated peptide amphiphiles as potent antimicrobial biomaterials to combat multidrug-resistant bacteria

et al. 2022

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Multiomics study on co-fermentation of chemically enhanced sludge and waste activated sludge to produce volatile fatty acids under different temperatures and pHs

Pan,

Tian,

Wang

2024

Journal of Environmental Chemical Engineering

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The impact of wheat straw and alfalfa additives on quality and in vitro digestibility of pumpkin (Cucurbita pepo) waste silage

Doğan Daş,

Avci,

Denek

et al. 2023

Journal of King Saud University - Science

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Effects of molasses interacting with formic acid on the fermentation characteristics, proteolysis and microbial community of seed-used pumpkin leaves silage

Cited by 6 publications

References 40 publications

Designing double-site lipidated peptide amphiphiles as potent antimicrobial biomaterials to combat multidrug-resistant bacteria

Designing double-site lipidated peptide amphiphiles as potent antimicrobial biomaterials to combat multidrug-resistant bacteria

Multiomics study on co-fermentation of chemically enhanced sludge and waste activated sludge to produce volatile fatty acids under different temperatures and pHs

The impact of wheat straw and alfalfa additives on quality and in vitro digestibility of pumpkin (Cucurbita pepo) waste silage

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