Effects of Moderate Exercise on the Biochemical, Physiological, Morphological and Functional Parameters of the Aorta in the Presence of Estrogen Deprivation and Dyslipidemia: an Experimental Model

Marchon, Claudia; Ornelas, Elisabete de Marco; Viegas, Kátia Aparecida da Silva; Lacchini, Sílvia; Souza, Romeu Rodrigues de; Fonseca, Fernando Luiz Affonso; Maifrino, Laura Beatriz Mesiano

doi:10.1159/000369705

Cited by 17 publications

(20 citation statements)

References 19 publications

(20 reference statements)

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“…This finding support the previous research which has successfully proven that exercise would prevent a weight gain in moderate intensity exercise group ovariectomized mice. 13 Lower weight gain in exercise group than control group also found in result study of 6 weeks moderate intensity exercise ovariectomized mice. 14 Other finding, that were performed MIE had higher blood estrogen level than control, but analysis independent t-test showed no significant difference (p>0.05).…”

Section: Discussionsupporting

confidence: 52%

Effect of Moderate Intensity Exercise on Body Weight and Blood Estrogen Level Ovariectomized Mice

Prasetya

Umijati²,

Rejeki³

2018

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Estrogen is a hormone which is related to lipid oxidation, lypogenesis inhibition, and lipolysis rate. The purpose of this study was to determine the effect of moderate intensity exercise on body weight and blood estrogen level in ovarectomized mice (ovx). The study was held in the Laboratory of Biochemistry, Faculty of Medicine Universitas Airlangga during the period of April to May 2017 on old nineteen 3-4 months old female mice, , 20-30 grams of weight, which were divided into two groups: OVX (n=9, ovx without exercise) and OVX+E (n=10, ovx and moderate intensity exercise). Moderate intensity exercise in this study included swimming, three times a week at 3 pm for four weeks using a 6% of body weight load. Experiment data were analyzed by paired t-test and independent t-test using SPSS. The average body weights of the OVX group were 26.44 ± 1.94 grams and 29.89 ± 2.62 gram at pretest and posttest, respectively., while for the OVX+E group, the weights were 26.50 ± 2.59 grams and 26.40 ± 2.07 grams. There were asignificant intergroup body weight differences (∆OVX= 3.44 ± 2.55 gram and ∆OVX+E=-1.00 ± 1.37 gram) with p=0.004. Blood estrogen level in OVX+E (12.04 ±10.13 ng/ml) was higher than in control (OVX= 11.24 ± 8.33 ng/ml); however, the difference was not significant (p=0.855). Moderate intensity exercise reduces body weight, without any significant increase in blood estrogen level. Hence, the body weight loss is not caused by estrogen, which may be due to the short period of exercise in this study that the estrogen has not had the time to increase.

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Section: Discussionsupporting

confidence: 52%

Effect of Moderate Intensity Exercise on Body Weight and Blood Estrogen Level Ovariectomized Mice

Prasetya

Umijati²,

Rejeki³

2018

mkb

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“…It is well known that Ang II is an important biologically active peptide from the RAS family which is effected by some factors such as exercise [ 36 , 37 ]. The discovery of Ang-(1-7) within the last decade added a new important component to the RAS family.…”

Section: Discussionmentioning

confidence: 99%

Angiotensin-(1-7) in Paraventricular Nucleus Contributes to the Enhanced Cardiac Sympathetic Afferent Reflex and Sympathetic Activity in Chronic Heart Failure Rats

Ren

Zhang

Zhao

et al. 2017

Cell Physiol Biochem

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Background/Aims: Cardiac sympathetic afferent reflex (CSAR) enhancement contributes to exaggerated sympathetic activation in chronic heart failure (CHF). The current study aimed to investigate the roles of angiotensin (Ang)-(1-7) in CSAR modulation and sympathetic activation and Ang-(1-7) signaling pathway in paraventricular nucleus of CHF rats. Methods: CHF was induced by coronary artery ligation. Responses of renal sympathetic nerve activity (RSNA) and mean arterial pressure (MAP) to epicardial application of capsaicin were used to evaluate CSAR in rats with anesthesia. Results: Ang-(1-7) increased RSNA, MAP, CSAR activity, cAMP level, NAD(P)H oxidase activity and superoxide anion level more significantly in CHF than in sham-operated rats, while Mas receptor antagonist A-779 had the opposite effects. Moreover, Ang-(1-7) augmented effects of Ang II in CHF rats. The effects of Ang-(1-7) were blocked by A-779, adenylyl cyclase inhibitor SQ22536, protein kinase A inhibitor Rp-cAMP, superoxide anion scavenger tempol and NAD(P)H oxidase inhibitor apocynin. Mas and AT₁ receptor protein expressions, Ang-(1-7) and Ang II levels in CHF increased. Conclusions: These results indicate that Ang-(1-7) in paraventricular nucleus enhances CSAR and sympathetic output not only by exerting its own effects but also by augmenting the effects of Ang II through Mas receptor in CHF. Endogenous Ang-(1-7)/Mas receptor activity contributes to CSAR enhancement and sympathetic activation in CHF, and NAD(P)H oxidase-derived superoxide anions and the cAMP-PKA signaling pathway are involved in mediating the effects of Ang-(1-7) in CHF.

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“…Several trials using biochemical and physiological parameters in ovariectomized females, have shown that physical activity has beneficial effects for both cardiac tissue and other body tissues. In ascending aortic dyslipidemic ovariectomized female mice, subjected to physical training, was evidenced lower percentage of visceral adipose tissue and decreased blood pressure as well as quantitative changes in the volume densities of elastic lamellae and collagen fibers 16 . In women with low levels of estrogen, physical activity resulted in reduction in blood pressure and improvements in myocardial activity and cardiac function 17 .…”

Section: Discussionmentioning

confidence: 95%

Effects of Physical Training on the Myocardium of Female LDL Knockout Ovariectomized Mice

Brianezi

Marques

Cardoso

et al. 2017

Rev Bras Med Esporte

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Introduction: The emergence of coronary heart disease increases with menopause, physical inactivity and with dyslipidemia. It is known that physical training promotes the improvement of cardiovascular functions. Objective: The purpose of this study was to investigate the effects of aerobic physical training on the left ventricle in female LDL knockout ovariectomized mice. Methods: Thirty animals were divided into 6 groups (n=5), namely, sedentary non-ovariectomized control; sedentary ovariectomized control; trained ovariectomized control; sedentary non-ovariectomized; sedentary ovariectomized; and trained ovariectomized. We analyzed the mean nuclear volume parameters, the cross sectional area of the myocytes, the apparent density of the capillaries, interstitium, myocytes and collagen fibers. Results: The results show that for the density of the number of nuclei, the physical activity decreased to values close to the ovariectomized control group. Regarding the mean nuclear volume and the average area of myocytes, training and ovariectomy promoted the elevation of these values but hypercholesterolemia was lower. the volume density of myocytes, hypercholesterolemia showed an increase of these values as well as the training. There was no change in the volumetric density of the capillaries and the density of collagen fibers. The training caused the decrease in the density of the interstitial volume, and the hypercholesterolemia changed to a smaller one than the control group. Conclusion: We concluded that the moderate aerobic activity or the training time used in our study were not sufficient to generate significant alterations in the hypercholesterolemic group.

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Effects of Moderate Exercise on the Biochemical, Physiological, Morphological and Functional Parameters of the Aorta in the Presence of Estrogen Deprivation and Dyslipidemia: an Experimental Model

Cited by 17 publications

References 19 publications

Effect of Moderate Intensity Exercise on Body Weight and Blood Estrogen Level Ovariectomized Mice

Effect of Moderate Intensity Exercise on Body Weight and Blood Estrogen Level Ovariectomized Mice

Angiotensin-(1-7) in Paraventricular Nucleus Contributes to the Enhanced Cardiac Sympathetic Afferent Reflex and Sympathetic Activity in Chronic Heart Failure Rats

Effects of Physical Training on the Myocardium of Female LDL Knockout Ovariectomized Mice

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