Effects of moderate dietary supplementations with n — 3 fatty acids on macrophage and lymphocyte phospholipids and macrophage eicosanoid synthesis in the rat

Influence of Dietary Fish Oil on the Aortic, Myocardial, and Renal Lesions of SHR.

“…The species and strain differences in the emergence of glomerulosclerosis seem to epitomize the complexity of the pathogenetic mechanisms of the glomerulosclerosis. Besides plasma lipid levels and composition, fish oil alters cell membrane lipid composition, neutrophil activation response, synthesis of eicosanoid, platelet function, and thrombogenicity (11,(25)(26)(27)(28). The exact mechanisms of biologic action of fish oil in this present experiment, therefore, are extremely complex and far from clear.…”

Fatty acids and the immune system: from basic science to clinical applications

“…Thus, fish oil feeding results in a decreased capacity of monocytes and macrophages to synthesize eicosanoids from AA. This effect has been demonstrated many times in a variety of animal models (for example, see Magrum & Johnston, 1983;Brouard & Pascaud, 1990;Chapkin et al 1992; and in human subjects (Lee et al 1985;Sperling et al 1993). In addition to effects on generation of eicosanoids from AA, EPA is potentially able to act as a substrate for both cyclooxygenase and 5-lipoxygenase (Fig.…”

Docosahexaenoic acid changes lipid composition and interleukin-2 receptor signaling in membrane rafts

“…Their presence in cell membrane phospholipids can increase membrane fluidity and regulate the functions of membrane receptors and enzymes. The immunomodulatory effects of PUFAs are associated with their ability to inhibit T-cell activation (7,8). However, this molecular alteration of PUFA-induced T-cell inhibition has not yet been elucidated.…”