Effects of moderate and high intensity isocaloric aerobic training upon microvascular reactivity and myocardial oxidative stress in rats

Paes, Lorena; Lima, D.; Matsuura, Cristiane; Souza, Maria das Graças de; Cyrino, Fátima Z. G. A.; Barbosa, Carolina; Ferrão, Fernanda M.; Bottino, Daniel; Farinatti, Paulo

doi:10.1371/journal.pone.0218228

Cited by 8 publications

(4 citation statements)

References 45 publications

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“…Gomes et al [ 42 ] have also shown that aerobic exercise is more superior in combating oxidative stress than resistance-type exercise. Further, some studies observed that well-trained exercise condition can even overcome high-intensity-induced oxidative damage in both aerobic and resistance exercise [ 43 , 44 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Different Exercise Modalities on Oxidative Stress: A Systematic Review

Thirupathi

Wang

Lin

et al. 2021

BioMed Research International

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Exercise-induced benefits are being increasingly recognized in promoting health and preventing diseases. However, initial adaption to exercise response can have different effects on cells, including an increase in the formation of oxidants and inflammatory mediators that ultimately leads to oxidative stress, but this scenario depends on the exercise type and intensity and training status of the individual. Therefore, we aimed to understand the effect of different types of exercise on oxidative stress. Indeed, exercise-induced minimum oxidative stress is required for regulating signaling pathways. According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, a search for relevant articles was carried out on PubMed/Medline, ISI Web of Science, and Google Scholar using a broad range of synonyms such as oxidants, reactive oxygen species (ROS), oxidative stress, exercise, physical training, aerobic exercise, and strength exercise until 2019. This study selected a total of 18 articles for assessing the oxidative damage using various parameters such as malondialdehyde (MDA), protein carbonyl (PCO), and F1-isoprostanes and enzymatic antioxidants. We observed that any type of exercise can increase the oxidative damage in an exercise type and intensity manner. Further, the training status of the individual and specific oxidative damage marker plays a crucial role in predicting earlier oxidative damage in the exercise condition. However, some of the studies that we included for review did not perform follow-up evaluations. Therefore, follow-up programs using larger numbers need to be performed to confirm our findings.

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Section: Discussionmentioning

confidence: 99%

Effect of Different Exercise Modalities on Oxidative Stress: A Systematic Review

Thirupathi

Wang

Lin

et al. 2021

BioMed Research International

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“…Three months of aerobic exercise is found to reduce GRP-78, IRE1, and p-eIF2 α mRNA and protein levels in subcutaneous fat tissue and blood mononuclear cells of obese adults [ 48 ]. Treadmill exercise training can reduce GRP-78, p-PERK, p-eIF2 α , ATF-6, XBP1, CHOP, and cleaved-caspase-3 expression to improve the cardiovascular function and reduce myocardial infarction in rats [ 49 ]. Correspondingly, 3 weeks of high-intensity treadmill exercise can strengthen the ER stress degree in the brain tissue of obese mice fed with a HFD, with the hypothalamus presenting the highest ER stress degree [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

Curcumin in Combination with Aerobic Exercise Improves Follicular Dysfunction via Inhibition of the Hyperandrogen‐Induced IRE1α/XBP1 Endoplasmic Reticulum Stress Pathway in PCOS‐Like Rats

Zhang

Weng

Wang

et al. 2021

Oxidative Medicine and Cellular Longevity

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Combining diet with exercise can improve health and performance. Exercise can reduce androgen excess and insulin resistance (IR) in polycystic ovary syndrome (PCOS) patients. Curcumin is also presumed to improve the follicle development disorder. Here, we investigated the effects of a combination therapy of oral intake of curcumin and exercise on hyperandrogen-induced endoplasmic reticulum (ER) stress and ovarian granulosa cell (GC) apoptosis in rats with PCOS. We generated a PCOS model via continuous dehydroepiandrosterone subcutaneous injection into the necks of Sprague Dawley rats for 35 days. PCOS-like rats then received curcumin treatment combined with aerobic (treadmill) exercise for 8 weeks. We found that compared to control rats, the ovarian tissue and ovarian GCs of hyperandrogen-induced PCOS rats showed increased levels of ER stress-related genes and proteins. Hyperandrogen-induced ovarian GC apoptosis, which was mediated by excessive ER stress and unfolded protein response (UPR) activation, could cause follicle development disorders. Both curcumin gavage and aerobic exercise improved ovarian function via inhibiting the hyperandrogen-activated ER stress IRE1α-XBP1 pathway. Dihydrotestosterone- (DHT-) induced ER stress was mitigated by curcumin/irisin or 4μ8C (an ER stress inhibitor) in primary GC culture. In this in vitro model, the strongly expressed follicular development-related genes Ar, Cyp11α1, and Cyp19α1 were also downregulated.

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“…Also, the research investigated the effect of isocaloric aerobic exercise with medium and high intensity on capillary reaction and heart muscle oxidative stress in rats. The results showed that higher exercise intensity caused more improvement in myocardial antioxidant defense, while the increase in capillary reactivity seems to depend more on exercise volume than exercise intensity (30).…”

Section: Resultsmentioning

confidence: 89%

The Effect of Aerobic Exercise on Oxidative Stress in Skeletal Muscle Tissue: A Narrative Review

et al. 2023

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Context: Performing intense aerobic exercise leads to an increase in the level of reactive oxygen species (ROS) and a decrease in the level of antioxidant enzymes in body tissues, especially skeletal muscles, and ultimately oxidative stress. Therefore, it is very important to measure oxidative stress before it causes damage to cells and destroys them. Evidence Acquisition: In this review, 92 articles were studied between 2012 and 2022, of which 54 were used. The search was done in Google Scholar, PubMed, Science Direct, and SID databases. An electronic search of studies was done using the keywords ROS, aerobic training, exercise, oxidative stress, antioxidant defense, skeletal muscle, and nuclear factor-erythroid 2-related factor 2 (NRF2). Results: The review of studies conducted in the field of antioxidant adaptations of skeletal muscle shows that the intensity and duration of activity are the main factors in controlling (creating or preventing) oxidative stress in skeletal muscle tissue. Also, taking antioxidant supplements before ROS levels reach peak physiological performance can reduce the beneficial effects of exercise. On the other hand, antioxidant treatment, after maximal performance related to ROS, can lead to reduced fatigue and/or improved performance. Conclusions: It seems that the increase in oxidative stress caused by aerobic exercise is a function of the amount of ROS production and the internal and external antioxidant defense capacity of the individual. However, different types of aerobic exercise along with various antioxidant supplements need to be performed for a long time in different people in order to achieve better approaches to early prediction of oxidative stress and reducing the destructive effects of skeletal muscle.

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Effects of moderate and high intensity isocaloric aerobic training upon microvascular reactivity and myocardial oxidative stress in rats

Cited by 8 publications

References 45 publications

Effect of Different Exercise Modalities on Oxidative Stress: A Systematic Review

Effect of Different Exercise Modalities on Oxidative Stress: A Systematic Review

Curcumin in Combination with Aerobic Exercise Improves Follicular Dysfunction via Inhibition of the Hyperandrogen‐Induced IRE1α/XBP1 Endoplasmic Reticulum Stress Pathway in PCOS‐Like Rats

The Effect of Aerobic Exercise on Oxidative Stress in Skeletal Muscle Tissue: A Narrative Review

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