Effects of Moderate Aerobic Exercise Training on Vascular Health and Blood Pressure in <scp>A</scp>frican <scp>A</scp>mericans

Feairheller, Deborah L.; Diaz, Keith M.; Kashem, Mohammed A.; Thakkar, Sunny R.; Veerabhadrappa, Praveen; Ling, Chenyi; Williamson, Sheara T.; Kretzschmar, Jan; Lee, Hojun; Grimm, Heather; Babbitt, Dianne M.; Vin, Charmie; Fan, Xiaoxuan; Crabbe, Deborah L.; Brown, Michael D.

doi:10.1111/jch.12328

Cited by 37 publications

(40 citation statements)

References 41 publications

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“…Previous studies in HIV-uninfected adults suggested that short term exercise training can improve endothelial function and vascular remodeling 41 . Additionally, enrollment in an exercise program improved FMD in young patients who were prehypertensive (aged 18–35) and overweight patients with coronary heart disease 42,43 .…”

Section: Discussionmentioning

confidence: 99%

The Effect of Physical Activity on Cardiometabolic Health and Inflammation in Treated HIV Infection

et al. 2015

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Background In HIV-uninfected populations, physical activity decreases mortality and inflammation. Inflammation is a potential cause for co-morbidities in HIV+ adults, the evidence examining the effect of physical activity on cardiometabolic health is limited. This analysis examines the relationship between physical activity, cardiometabolic health and inflammation. Methods We conducted a nested study within the SATURN-HIV trial in which 147 HIV+ adults were randomized to 10 mg daily rosuvastatin or placebo. Measures of physical activity, cardiometabolic health, inflammation, and vascular disease (carotid artery intima media thickness and Computed Tomography-acquired measures pericardial fat volume) were assessed at baseline and through 96 weeks . Spearman correlations and multivariable analyses were used to explore relationships between physical activity, cardiometabolic health and inflammation. Results Median age (Q1, Q3) was 46 (40.4, 52.7) years, 80% were male, 69% were African American and 46% on protease inhibitors. Baseline median physical activity was 44 minutes per week (0, 150), 24% of participants performed greater than 150 minutes per week. At baseline, physical activity correlated with several markers of cardiometabolic health and inflammation (all p≤0.05). Over all time points median physical activity was independently associated with carotid distensibility (β = 2.53, p = 0.008), pericardial fat volume (β = −6.13, p = 0.001) and IL 6 (β = −0.468, p < 0.001). Conclusions Physical activity is associated with vascular disease, endothelial function, and may be an adjuvant to decreasing co-morbidities in HIV+ adults. Further studies should examine long-term effects of physical activity on cardiometabolic health and inflammation in this population.

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Section: Discussionmentioning

confidence: 99%

The Effect of Physical Activity on Cardiometabolic Health and Inflammation in Treated HIV Infection

et al. 2015

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“…Kebiasaan olahraga, terutama aerobik, penting pada prevensi aterosklerosis. Hasil penelitian pada orang Afrika Amerika, menunjukkan bahwa melakukan aerobik selama 8 minggu atau 6 minggu dapat memperbaiki struktur dan fungsi vaskuler (6). Kapasitas pengambilan oksigen maksimal disesuaikan dengan berat yang berbanding terbalik dengan CIMT.…”

Section: Hubungan Antara Cimt Dengan Faktor Risiko Kardiovaskuler unclassified

Penyebab Perubahan Ketebalan Carotid Intima-Media

Waskito

2018

J.Ilm.Kedokt. Wijaya Kusuma

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Atherosclerosis causes significant morbidity and mortality. Carotid intima-media thickness (CIMT) can predict the onset of cardiovascular and ischemic stroke in the future. CIMT, the measurement of atherosclerosis, is determined in vivo using carotid ultrasound. CIMT is associated with traditional cardiovascular risk factors such as age, sex, race, smoking habits, alcohol consumption, exercise habits, blood pressure, dyslipidemia, dietary patterns, medications used, glycemia, hyperuricemia, anthropometric parameters associated with obesity. In addition, CIMT is also associated with novel risk factors, ie genotypes, cardiovascular anthropometry parameters, rheumatoid arthritis, immunologic diseases, inflammatory cytokines, lipid peroxidation, chemocyte anthropometric parameters, infectious diseases, vitamin D, matrix metalloproteinases, and other diseases

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“…On the prevalence of different types of breed, Feairheller et al (28) point out that according to the American Heart Association (AHA), African-Americans have a higher prevalence in cardiovascular diseases and greater oxidative stress and inflammation levels in endothelial cells compared to Caucasian individuals.…”

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confidence: 99%

Aerobic Exercise and Endothelium

Almeida¹,

Rica²,

Evangelista³

et al. 2020

mtprehabjournal

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Background: A few years ago, it was believed that the endothelium was just a membrane separating blood from the outermost layers of blood vessels. However, it has now become recognized as a mediator of vasoconstricting and vasodilatory substances, regulating vessel tone through the information received. The main vasodilatory substance released by the endothelium is nitric oxide, a gas responsible for the inhibition of neovascular growth and platelet aggregation, modulating inflammation and coagulation, and can be released through physical and humoral stimuli. Exercise is considered the best non-pharmacological mechanism in the prevention and treatment of cardiovascular diseases, by promoting greater blood flow, generating blood shear forces on the vessel wall and thus releasing nitric oxide, the most important vasodilator produced by the endothelium. Objective: Verify the effects of aerobic exercise on the endothelium. Methods: We reviewed the studies that evaluated the effects of aerobic exercise and its intensities on the endothelium. Results: According to the studies reviewed in this research, impaired endothelial function improves through aerobic training, whether low, moderate or high intensity. Conclusion: Physical activity, specifically aerobic exercise is an important tool in the production of nitric oxide, responsible for blood vasodilation, inhibition of platelet aggregation among other symptoms of endothelial dysfunction.

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Effects of Moderate Aerobic Exercise Training on Vascular Health and Blood Pressure in African Americans

Cited by 37 publications

References 41 publications

The Effect of Physical Activity on Cardiometabolic Health and Inflammation in Treated HIV Infection

The Effect of Physical Activity on Cardiometabolic Health and Inflammation in Treated HIV Infection

Penyebab Perubahan Ketebalan Carotid Intima-Media

Aerobic Exercise and Endothelium

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