Effects of mode of delivery on maternal–neonatal plasma antioxidant status and on protein S100B serum concentrations

Schulpis, K. H.; Margeli, Alexandra; Akalestos, Athanassios; Vlachos, Georgios; Partsinevelos, George A.; Papastamataki, Maria; Antsaklis, Aris; Papassotiriou, Ioannis

doi:10.1080/00365510600977737

Cited by 32 publications

(19 citation statements)

References 35 publications

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“…However, it is important to note that they can be elevated in other settings. S100B levels, for example, are markedly increased by intrauterine growth restriction or chronic hypoxia,30 are is common during recovery from HI),31 perinatal infection/inflammation, central and peripheral hypoperfusion (which are is common during recovery from HI),31 perinatal infection/inflammation,32,33 traumatic delivery,34 pre-existing neural injury,35 treatments such as prenatal maternal glucocorticoids and anesthetics,36,37 and preterm gestational age,38 as well as being affected by the sex of the infant 36,37,39. Further, the brain does not appear to be the only source for S100B and NSE, for example, which may be released from a variety of tissues, including the umbilical cord and placenta 40…”

Section: Introductionmentioning

confidence: 99%

Potential biomarkers for hypoxic–ischemic encephalopathy

Bennet

Booth

Gunn

2010

Seminars in Fetal and Neonatal Medicine

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Section: Introductionmentioning

confidence: 99%

Potential biomarkers for hypoxic–ischemic encephalopathy

Bennet

Booth

Gunn

2010

Seminars in Fetal and Neonatal Medicine

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“…On the other hand, S100B is a calcium‐binding protein, predominantly expressed by astrocytes in vertebrate brain (Marenholz et al, 2004), although some evidence has suggested its production in other non‐cerebral tissues, such as adipocytes (Steiner et al, 2007). Increased serum S100B levels have been shown after exposure to stress in rats (Scaccianoce et al, 2004; Diehl et al, 2007) and humans (Schulpis et al, 2006). Serum S100B is influenced by diet and by body weight gain (Holtkamp et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Effects of a chronic exposure to a highly palatable diet and its withdrawal, in adulthood, on cerebral Na⁺,K⁺‐ATPase and plasma S100B in neonatally handled rats

Benetti

Silveira

Matté

et al. 2009

Intl J of Devlp Neuroscience

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We have previously demonstrated that early environment influences the metabolic response, affecting abdominal fat deposition in adult female rats exposed to a long-term highly caloric diet. In the present study, our goal was to verify the effects of the chronic exposure, in adulthood, to a highly palatable diet (chocolate) on cerebral Na+,K+-ATPase activity and S100B protein concentrations, and the response to its withdrawal in neonatally handled and non-handled rats. We measured the consumption of foods (standard lab chow and chocolate), body weight gain, S100B protein concentrations, as well as cerebral Na(+),K(+)-ATPase activity during chronic exposure and after chocolate withdrawal in adult female rats that had been exposed or not to neonatal handling (10 min/day, 10 first days of life). Non-handled rats chronically exposed to chocolate exhibited increased plasma S100B levels, but there was no difference in abdominal fat S100B concentration between groups. Chronic chocolate consumption decreased Na+,K+-ATPase activity in both amygdala and hippocampus in non-handled, but not in handled rats, and this effect disappeared after chocolate withdrawal. Non-handled animals also demonstrated increased frequency of head shaking in the open field after 24h of chocolate withdrawal in comparison to handled ones. These findings suggest that neonatal handling modifies the vulnerability to metabolic and brain alterations induced by chronic exposure to a highly palatable diet in adulthood.

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“…In this study, the absence of a serious TAS reduction in the blood of the neonates, especially in those of Group B, which also indicates the peroxidation of lipids, may be due to the presence of low levels of lipids, and, especially, due to the very low LDL levels in the CB of the infants, and/or the placenta protective eVect against oxidative stress (Schulpis et al 2006.…”

Section: Discussionmentioning

confidence: 51%

“…Our previous studies (Schulpis et al 2006 showed that normal and/or prolonged labor and deliveries are implicated with low total antioxidant status (TAS) in mothers, post-delivery. In addition, erythrocyte membrane Na + , K + -ATPase activity was found modulated in athletes after endurance exercise in whom the TAS levels were measured to be low in the blood and their plasma catecholamines were remarkably increased.…”

Section: Introductionmentioning

confidence: 99%

Maternal–neonatal erythrocyte membrane Na+, K+-ATPase and Mg2+-ATPase activities in relation to the mode of delivery

Vlachos¹,

Schulpis

Parthimos³

et al. 2008

Eur J Appl Physiol

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Free radical production and high catecholamine levels are implicated in the modulation of Na(+), K(+)-ATPase, and Mg(2+)-ATPase activities. The aim of this study was to investigate the effect of the mode of delivery on the above-mentioned enzyme activities in maternal-neonatal erythrocyte membrane. Women with normal pregnancy (N = 30) were divided into two groups: Group A (N = 16) with normal labor and vaginal delivery, and Group B (N = 14) with scheduled cesarean section; 20 non-pregnant women were the controls. Blood was obtained from controls and mothers, pre- versus post-delivery, and from the umbilical cord (CB). Total antioxidant status (TAS), membrane enzyme activities, and catecholamine blood levels were measured with a commercial kit, spectrophotometrically, and by HPLC methods, respectively. The results showed that: TAS levels, catecholamine, and the membrane enzyme activities were similar in the two groups of mothers pre-delivery, whereas both enzyme activities were lower than those of controls. TAS levels were reduced whereas Na(+), K(+)-ATPase activities (0.35 +/- 0.03 vs. 0.65 +/- 0.06 micromol Pi/h x mg protein, P < 0.001), and catecholamine levels were increased post-delivery in mothers of Group A and unaltered in Group B (0.38 +/- 0.02 vs. 0.40 +/- 0.03 micromol Pi/h x mg protein, P > 0.05), at the same times of study. Mg(2+)-ATPase activities remained unaltered in both groups of mothers and newborns. Na(+), K(+)-ATPase activity was similarly lower in the CB of neonates than those of their mothers, pre-delivery. Our results suggest that: (a) during a normal vaginal delivery process, the low TAS and the increased levels of catecholamines may increase Na(+), K(+)-ATPase activity, post-delivery; (b) the low enzyme activities evaluated in mothers pre-delivery may be due to the high estrogen levels and those in newborns due to perinatal immaturity.

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Effects of mode of delivery on maternal–neonatal plasma antioxidant status and on protein S100B serum concentrations

Cited by 32 publications

References 35 publications

Potential biomarkers for hypoxic–ischemic encephalopathy

Potential biomarkers for hypoxic–ischemic encephalopathy

Effects of a chronic exposure to a highly palatable diet and its withdrawal, in adulthood, on cerebral Na⁺,K⁺‐ATPase and plasma S100B in neonatally handled rats

Maternal–neonatal erythrocyte membrane Na+, K+-ATPase and Mg2+-ATPase activities in relation to the mode of delivery

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Effects of mode of delivery on maternal–neonatal plasma antioxidant status and on protein S100B serum concentrations

Cited by 32 publications

References 35 publications

Potential biomarkers for hypoxic–ischemic encephalopathy

Potential biomarkers for hypoxic–ischemic encephalopathy

Effects of a chronic exposure to a highly palatable diet and its withdrawal, in adulthood, on cerebral Na+,K+‐ATPase and plasma S100B in neonatally handled rats

Maternal–neonatal erythrocyte membrane Na+, K+-ATPase and Mg2+-ATPase activities in relation to the mode of delivery

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Effects of a chronic exposure to a highly palatable diet and its withdrawal, in adulthood, on cerebral Na⁺,K⁺‐ATPase and plasma S100B in neonatally handled rats