Effects of mobile phone use on brain tissue from the rat and a possible protective role of vitamin C – a preliminary study

Imge, Ergüder B; Kilicoglu, Bulent; Devrım, Erdinç; Çetin, Recep; Durak, İlker

doi:10.3109/09553002.2010.501838

Cited by 21 publications

(10 citation statements)

References 44 publications

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“…It is well accepted that vitamin C is the potent antioxidant (39) in biological fluids for protection against degenerative processes of oxidative stress in the brain and other tissues (3,23,24,40).…”

Section: Discussionmentioning

confidence: 99%

Vitamin C Improves Passive Avoidance Learning and Memory in Rats Exposed to Radiofrequency Waves Generated by a Base Transceiver Station (BTS) Antenna Model

Jelodar

Soleimani

Azimzadeh

2018

Zahedan J Res Med Sci

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Background: Hazardous health effects of the exposure to radiofrequency waves (RFWs) have become of great public concern and impaired memory has been reported following the exposure to electromagnetic radiations. Objectives: As the deleterious effects of the RFW on passive avoidance learning and memory had already been reported, the aim of this study was to evaluate the prophylactic effect of vitamin C on this activity. Methods: 20 male Sprague-Dawley rats (230 ± 20 g) were divided randomly into four groups as: control, control-exposed (exposed to 900 MHz RFW), control treatment (without exposure to RFW receiving 250 mg/kg of body weight/day L-ascorbic acid by gavage), and treatment (exposed to 900MHz RFW receiving the abovementioned dose of vitamin C) groups. The exposure was performed for 30 consecutive days (4 h/day). Learning and memory were evaluated in the last day by the shuttle box and expressed as the period of remaining within the light area; this time was called "light time". Results: The exposure to RFW significantly decreased the duration of light time in the control-exposed group compared to the other three groups (P < 0.05). In the fourth group, vitamin C significantly increased the light time compared to the control-exposed group (P < 0.05). No significant difference was observed between control, control treatment, and treatment groups. Conclusions: Exposure to RFW significantly altered the passive avoidance behavior. Vitamin C probably due to its antioxidant effects has facilitative results on the acquisition and retrieval activities of passive avoidance learning and memory in rats.

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Section: Discussionmentioning

confidence: 99%

Vitamin C Improves Passive Avoidance Learning and Memory in Rats Exposed to Radiofrequency Waves Generated by a Base Transceiver Station (BTS) Antenna Model

Jelodar

Soleimani

Azimzadeh

2018

Zahedan J Res Med Sci

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“…Results of the current study showed that vitamin C significantly reduced pituitary oxidative stress and apoptosis as reflected by decreased levels of MDA, 8-OHdG, and caspase-3 and increased levels of SOD compared to rats exposed to mobile phone EMR. Vitamin C is a powerful natural antioxidant that protects cells from the damaging effect of ROS by scavenging free radicals [27]. In addition, previous reports showed that vitamin C can prevent EMRinduced oxidative stress damage and apoptosis of endometrium and brain cells [27] [28].…”

Section: Resultsmentioning

confidence: 99%

Protective effect of Date Palm Fruits (Phoenix Dactylifera L.) versus vitamin C against mobile Phone Radiation-induced Pituitary gland damage in rats

Mohamed

Rahman

Ali

et al. 2022

Zagazig University Medical Journal

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Background: Date palm fruit is one of the most precious nutraceutical compounds. Now, it is well established that mobile phone radiation causes deleterious health hazards. The pituitary gland is the master gland in the human body and is highly affected by mobile phone radiation as it's the nearest part of the body to mobile phones during calls. This study was designed to investigate the cytoprotective effect of date palm fruit against the mobile phone radiationinduced pituitary gland damage compared to vitamin C. Methods: Male Wister albino rats were exposed to mobile phone electromagnetic radiations (EMR) for 1 hour per day for 4 weeks. Rats were divided into 4 groups: control normal, EMR, EMR+ vitamin C (100 mg/kg), and EMR+ date palm fruit groups. Pituitary oxidative stress markers (malondialdehyde, MDA, and superoxide dismutase, SOD), DNA damage (8hydroxy-2'deoxyguanosine, 8-OHdG), and apoptosis (caspase 3) were assessed. Results: Mobile phone radiation significantly increased pituitary gland oxidative stress, DNA damage, and apoptosis while both vitamin C and date palm fruit significantly alleviated these detrimental effects with superior cytoprotective effect for date palm fruit over vitamin C. Conclusions: These results can introduce date palm fruit as an affordable nutraceutical agent owing to its antioxidant and antiapoptotic properties.

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“…Based on other similar studies, it is also advised to consume a balanced, nutritious diet that provides adequate antioxidants, as antioxidants have been proved to be protective against damage by electromagnetic radiation-induced oxidative stress. [22,23] …”

Section: Discussionmentioning

confidence: 99%

Does the duration of mobile phone usage affect the human auditory system? A middle latency auditory-evoked potential study in young adults

J¹,

Arunkumar²,

Roopakala³

2018

Natl J Physiol Pharm Pharmacol

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Background: Mobile phones emit microwave range of electromagnetic radiations. The human auditory cortex has a greater chance of being affected by these radiations due to the close proximity during usage. Middle latency auditory-evoked potential (MLAEP) recording helps in testing the integrity of the thalamo-cortical pathway of the human auditory system. Aims and Objectives: The aims and objectives are (1) to compare the latencies of MLAEPs in short-and long-term mobile phone users based on years of usage and (2) to compare the latencies of MLAEPs in mobile phone users grouped based on the duration of usage per day. Materials and Methods: MLAEP recording was done in 20 short-and long-term mobile users described as the history of usage of mobile phone less than and more than 1 year, respectively. Further, the group was categorized based on the duration of usage per day. Mean latencies of the MLAEP waves Na, Pa, and Nb were measured and compared statistically using Student's t-test (two tailed, independent) and Mann-Whitney U test. Results: The mean latencies of MLAEP waveforms in both the ears were found to be significantly increased in long-term mobile phone users and in individuals who use mobile phones for more than 1 h per day. Conclusion: The study shows that long-term usage, as well as longer duration of usage of mobile phones, significantly affects the nerve conduction velocity in the thalamo-cortical region of the human auditory pathway.

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Effects of mobile phone use on brain tissue from the rat and a possible protective role of vitamin C – a preliminary study

Abstract: Our results suggest that vitamin C may play a protective role against detrimental effects of mobile phone radiation in brain tissue.

Cited by 21 publications

References 44 publications

Vitamin C Improves Passive Avoidance Learning and Memory in Rats Exposed to Radiofrequency Waves Generated by a Base Transceiver Station (BTS) Antenna Model

Vitamin C Improves Passive Avoidance Learning and Memory in Rats Exposed to Radiofrequency Waves Generated by a Base Transceiver Station (BTS) Antenna Model

Protective effect of Date Palm Fruits (Phoenix Dactylifera L.) versus vitamin C against mobile Phone Radiation-induced Pituitary gland damage in rats

Does the duration of mobile phone usage affect the human auditory system? A middle latency auditory-evoked potential study in young adults

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