Effects of mobile phone radiation (900 MHz radiofrequency) on structure and functions of rat brain

Abstract

Thus our findings indicate extensive neurodegeneration on exposure to radio waves. Increased production of reactive oxygen species due to exhaustion of enzymatic and non-enzymatic antioxidants and increased lipid peroxidation indicate extensive neurodegeneration in selective areas of CA1, CA3, DG, and the cerebral cortex. This extensive neuronal damage results in alterations in behavior related to memory and learning.

Hippocampal lipidome and transcriptome profile alterations triggered by acute exposure of mice to GSM 1800 MHz mobile phone radiation: An exploratory study

“…Importantly, the altered expression of genes implicated in the lipid metabolism may be associated with the changes that we observed on the fatty acid levels in the lipidomics analysis. Particularly, Acadl, the product of which catalyzes the initial step of mitochondrial beta-oxidation of straight-chain fatty acids, was found (Nittby, Widegren, et al, 2008) and lipid peroxidation changes (Saikhedkar et al, 2014;Shahin, Singh, & Chaturvedi, 2017) following EMR exposure support our observations.…”

“…The significance of such changes is valuable for elucidating the mechanism of action of the MP radiation, as it implicates that a specific lipid composition aggravates certain cell communication abnormalities caused by MP radiation. Studies showing hippocampal genome profile alterations associated with membrane functions (Nittby, Widegren, et al., ) and lipid peroxidation changes (Saikhedkar et al., ; Shahin, Singh, & Chaturvedi, ) following EMR exposure support our observations.…”

“…Furthermore, the fact that mechanisms such as LTP, calcium signaling, cell cycle regulation, and death were affected may be associated with the increased Ca 2+ influx, apoptosis, synaptic changes, pyramidal cell loss, and reactive astrocytosis, which all have been reported to occur following MP radiation exposure (Bas, Odaci, Mollaoglu, Ucok, & Kaplan, ; Bas, Odaci, Kaplan, et al., ; Li et al., ; Maskey et al., ; Moghimi, Baharara, & Musavi, ; Narayanan et al., ; Odaci, Bas, & Kaplan, ; Sahin et al., ) and hence lead to learning and memory deficits, as previously reported by our group (Fragopoulou et al., ) and other groups (Li et al., ; Moghimi et al., ; Narayanan et al., ; Saikhedkar et al., ; Wang et al., ).…”

Possible cause for altered spatial cognition of prepubescent rats exposed to chronic radiofrequency electromagnetic radiation

“…Jiang et al (2013) have reported that, RF-EMR exposure induced, cognitive and memory impairment, oxidative stress and overexpression of beta amyloid protein in rat hippocampus. Furthermore, a very recent study by Saikhedkar et al (2014) demonstrated that, 900 MHz exposure (4 h/day) for a period of 15 days induced learning and memory deficits and this was correlated with hippocampal neuronal degeneration in rats.…”

Effects of 1.8 GHz radiofrequency field on microstructure and bone metabolism of femur in mice

“…RF field is a kind of electromagnetic field (EMF) in frequencies ranging from 100 kHz to 300 GHz, and has gone through phenomenal development and deployment worldwide during the last several decades, especially in wireless communications such as mobile phones, base stations, and laptops. RF field emitted from mobile phones has been mainly at frequencies 800-2000 MHz [Chen et al, 2005], which can induce adverse health effects, such as brain tumors [Morgan et al, 2015], infertility [La Vignera et al, 2012;Merhi, 2012;Sepehrimanesh et al, 2017], genotoxic effects [Atli et al, 2013;Duan et al, 2015], fatigue, rapid exhaustibility [Schoeni et al, 2015], increased anxiety, poor learning [Saikhedkar et al, 2014], and so on. Meanwhile, other studies showed beneficial effects or no effects of RF field on biological tissue [Kismali et al, 2012;Ahlers and Ammerm€ uller, 2014;Gurbuz et al, 2014].…”