Effects of mixture powder of black rice (Oryza sativa L indica), red beans (Phaseolus vulgaris L), and moringa leaves (Moringa oleifera L) on blood glucose concentration in hyperglycemic Rats

Abstract

Background: Diabetes mellitus, increased blood glucose or hyperglycemia, is associated with increased oxidative stress and cardiovascular diseases. This condition will further cause carbohydrate and fat metabolism change, resulting in the decreased antioxidant defense system. Black rice, red beans, and moringa leaves contain oleic acid, butyric amino acid, antioxidants, phytic acid, and arginine, which can improve insulin sensitivity, and blood glucose homeostasis.Objective: This study aimed to analyze the effect of betamelor (black rice, red beans, and moringa leaves) on blood glucose in ratsMaterials and Methods: The design of this research was experimental research with pre-and post-control group design. A total of 20 Sprague Dawley female rats were divided into four groups, namely standard feed (PS), 80% feed of betamelor (PB8), 50% feed of betamelor (PB5), and 20% feed of betamelor (PB2). Betamelor intervention was given as much as 5% of weight for 28 days. Fasting Blood Glucose (FBG) levels were measured using the GOD-PAP method. Blood glucose data were analyzed by Analysis of Variance (ANOVA) at a 95% confidence level and using Duncan's test.Results: There were differences in FBG between groups after the intervention of betamelor. The results showed that after 28 days of intervention, betamelor decreased the serum glucose concentration from 122.69 mg / dL to 97.70 mg / dL (20.37%) in the PB8 group and from 123.91 mg / dL to 113.28 mg / dL (8.58%) in the PB5 group, but the standard diet (PS) increased by 5.73%. This result can be applied to reduce blood glucose levels in obese and patients with metabolic syndrome.Conclusions: There was a significant effect of giving a mixture of black rice, red beans, and Moringa leaves on fasting blood sugar in rats.

Effect of Red Beans and Black Beans With a Diabetes Mellitus: A Systematic Review

“…The results of another study conducted by another study showed that after 28 days of intervention, the mixed powder reduced blood glucose levels in male Wistar rats that were given a glucose load. 21 This is due to the administration of mixed flour in the group containing a high fiber composition, causing satiety quickly compared to the standard feed group. In this study, the mixed powder was used as a flour mixture in the intervention feed, one of the compositions of which was red bean, so that a decrease in fasting blood sugar levels in animal models could be associated with red bean.…”

Pengaruh pemberian ekstrak bekatul beras hitam (Oryza sativa L. indica) terhadap kadar MDA, SOD dan trigliserida pada tikus diabetes mellitus tipe 2

“…Pada penelitian sebelumnya menunjukkan pengaruh pemberian antioksidan yang terkandung dalam beras hitam, kacang merah dan daun kelor (betamelor) pada hewan coba selama 28 hari dapat menurunkan kadar glukosa darah dari 122,69 mg/dL menjadi 97,70 mg/dL dan 123,91 mg/dL menjadi 113,28 mg/dL dengan pemberian pakan betamelor sebanyak 80% dari 5% berat badan (Utama et al, 2021). Penelitian lainnya yang menggunakan Caralluma europaea, yang merupakan tanaman obat tradisional untuk mengobati diabetes mellitus di Maroko.…”