Effects of mixed organic acids and medium chain fatty acids as antibiotic alternatives on the performance, serum immunity, and intestinal health of weaned piglets orally challenged with Escherichia coli K88

Han, Yunsheng; Zhan, Tengfei; Zhao, Qingyu; Tang, Chaohua; Zhang, Kai; Han, Yanming; Zhang, Junmin

doi:10.1016/j.anifeedsci.2020.114617

Cited by 19 publications

(16 citation statements)

References 49 publications

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“…Dietary supplementation of MCFAs increased villus height and a ratio of villus height to crypt depth but decreased crypt depth of weanling piglets [ 23 ]. MCFAs added in the diet of weanling piglets can effectively release situations of jejunal callus atrophy, epithelium cell shedding, and reduced villus height induced by lipopolysaccharides, resulting in decreasing mucosal damage of piglets and protecting immunological barrier integrity of intestinal mucosa [ 24 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, there is limited research on the roles of extracted MCFAs in regulating antioxidant functions of the host. Organic acids combined with MCFAs in the diet improved T-AOC but decreased MDA in the serum of weanling piglets compared with a diet containing organic acids [ 25 ]. In our study, a diet supplemented with sodium decanoate increased the concentrations of SOD and GSH-Px, but reduced the MDA content in the serum of mice.…”

Section: Discussionmentioning

confidence: 99%

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Sodium Decanoate Improves Intestinal Epithelial Barrier and Antioxidation via Activating G Protein-Coupled Receptor-43

Zhao

2021

Nutrients

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The study was conducted to explore actions of decanoic acid on regulating intestinal barrier and antioxidant functions in intestinal epithelium cells isolated from porcine jejunum (IPEC-J2) and C57/BL6 mice models. In vitro and vivo assays, mice and IPEC-J2 cells treated by H2O2 were disposed of sodium decanoate and sodium butyrate to determine intestinal barrier and antioxidant functions of the host. Results showed that sodium decanoate upregulated expression of tight junction proteins and improved antioxidant capacity in both IPEC-J2 cells treated by H2O2 and mice models (p < 0.05). Sodium decanoate increased weight gain and ileal villus height of mice compared with control and sodium butyrate treatments (p < 0.05). Sodium decanoate increased α-diversity of ileal microbiota, volatile fatty acids concentration, and G protein-coupled receptor-43 (GPR-43) expression in the ileum and colon of mice (p < 0.05). In conclusion, sodium decanoate improved antioxidant capacity, intestinal morphology, and gut physical barrier of intestinal epithelial cells, resulting in an increase growth performance of mice, which is mediated through activating GPR-43 signaling.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Sodium Decanoate Improves Intestinal Epithelial Barrier and Antioxidation via Activating G Protein-Coupled Receptor-43

Zhao

2021

Nutrients

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“…Weaning stress is generally associated with a decrease in feed intake and feed conversion ratio as well as nutritional, social, and immunological disorders which negatively affect the growth performance of piglets. The present study employed an E. coli K88-induced weaning-like stress model to evaluate the effects of different combinations of IgY and PM as AGPs alternatives on growth performance and health of weaned pigs [ 27 , 28 ]. In recent years, IgY and PM have been separately applied in livestock production, while the effects of combined IgY and PM on weaning piglets challenged with E. coli k88 were not reported.…”

Section: Discussionmentioning

confidence: 99%

“…In the current study, E. coli K88 challenge significantly increased pro-inflammatory cytokines IL-1β, IL-6, and TNF-α on day 17, which then normalized by day 42. This might be equated to the disruption of intestinal morphology resulting from E. coli K88 challenge [ 28 ]. As reported, IgY administration could effectively suppress E. coli -induced inflammatory cytokines IL-6 and TNF-α upregulation in intestine of piglets [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

“…Escherichia coli ( E. coli ) has been described as one of the most important pathogens for piglets suffering PWD [ 21 , 22 , 23 , 24 ], causing severe inflammatory processes and disrupting gut morphology, which can increase morbidity and mortality of piglets [ 24 , 25 , 26 , 27 ]. Moreover, previous studies have used piglets challenged with E. coli K88 as a weaning stress model [ 27 , 28 ]. Thus, the present study used an E. coli K88 challenging model in piglets to evaluate the effects of combination of IgY and PM as alternatives to AGP on the growth performance, serum immunity, and intestinal health of weaned piglets.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Replacing in-Feed Antibiotic Growth Promoters with a Combination of Egg Immunoglobulins and Phytomolecules on the Performance, Serum Immunity, and Intestinal Health of Weaned Pigs Challenged with Escherichia coli K88

Han

Zhan

Tang

et al. 2021

Animals

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The study was conducted to investigate the effects of replacing antibiotic growth promoters (AGPs) with an egg immunoglobulin (IgY) combined with phytomolecules (PM) on the growth rate, serum immunity, and intestinal health of weaned pigs challenged with Escherichia coli K88 (E. coli K88). A total of 192 piglets were weaned at 28 days old with an average weight of 7.29 (± 0.04) kg. They were randomly divided into four treatments containing eight replicates with six piglets per replicate. The treatment groups were NC and PC fed a basal diet, AGP fed a basal diet supplemented with 75 mg/kg chlortetracycline, 50 mg/kg oxytetracycline calcium, and 40 mg/kg zinc bacitracin, IPM fed a basal diet supplemented with IgY at dose of 2.5 g/kg and 1.0 g/kg and PM at dose of 300 mg/kg and 150 mg/kg during days 1 to 17 and 18 to 42, respectively. On days 7 to 9 of the experiment, piglets in the PC, AGP, and IPM groups were orally challenged with 20 mL E. coli K88 (109 CFU/mL), while piglets in the NC group were challenged with 20 mL medium without E. coli K88. The E. coli K88 challenge model was successful as the incidence of post-weaning diarrhea (PWD) of piglets challenged with E. coli K88 was significantly higher than that of those unchallenged piglets during the challenge time (days 7 to 9) and days 1 to 7 of post-challenge (p < 0.05). A diet with combinations of IgY and PM and AGPs significantly decreased the incidence of PWD during the challenge time and days 1 to 7 of post-challenge (p < 0.05) compared to the PC group and significantly improved the ratio of feed to weight gain (F:G) during days 1 to 17 of the experiment compared to the NC and PC groups (p < 0.05). In comparison with the PC group, piglets in the IPM group had significantly higher serum levels of IgA, IgG, and IgM (p < 0.05), but lower serum IL-1β on day 17 of experiement (p < 0.05). Besides, diet supplementation with AGP significantly decreased serum IL-1β, IL-6, and TNF-α on days 17 and 42 (p < 0.05) with comparison to the PC group. Piglets in the IPM group showed a significantly lower level of fecal coliforms (p < 0.05), but a higher villus height of jejunum and ileum and higher ratio of villus height to crypt depth of duodenum and jejunum (p < 0.05) than those piglets in the PC group. In summary, diet supplementation with a mixture of IgY and PM decreased the incidence of PWD and coliforms, increased feed conversion ratio, and improved intestinal histology and immune function.

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Dietary feed nanozeolite, Pediococcus, and medium-chain fatty acid enhanced growth performance and transcription of growth-related gene of Nile tilapia (Oreochromis niloticus)

Elshafy,

El-Monem,

Khattab

et al. 2024

Aquacult Int

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The current trial was designed to evaluate the positive impacts of different feed additives singly or in combination on the growth performance, nutritional parameters, intestinal histology, and gene expression of some growth and fat metabolism-related genes in the liver tissue of Nile tilapia. The experimented fish were allocated into eight groups in a glass aquarium (10 fish/aquarium in triplicate) with Pediococcus acidilactici, nanozeolites, and/or medium-chain fatty acid additives. The studied treatments were control (T0), nanozeolite (T1), Pediococcus (T2), medium-chain fatty acid (T3), nanozeolite + Pediococcus (T4), nanozeolite + medium-chain fatty acid (T5), Pediococcus + medium-chain fatty acid (T6), and nanozeolite + Pediococcus + medium-chain fatty acid (T7). The results of the growth and nutritional parameters (i.e., final body weight, total weight gain, feed intake, specific growth rate, feed conversion ratio, and protein efficiency ratio) of tilapia-fed diets supplemented with Pediococcus, nanozeolites, and medium-chain fatty acids improved, but the combination of these additives was significantly more effective. Moreover, expression of growth hormone receptor 1 gene was upregulated (P ≤ 0.05) in T7 fish when compared with T0, other groups showing intermediate values. Expression of insulin-like growth factor-1 was upregulated (P ≤ 0.05) in T5, T6, and T7 fish when compared with the other groups. The expression of the fatty acid-binding protein was higher in T6 and T7 fish (P ≤ 0.05) when compared with T0, T1, and T3 fish. In conclusion, combined additives had significant effects on improving growth and regulating growth-related genes.

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Effects of mixed organic acids and medium chain fatty acids as antibiotic alternatives on the performance, serum immunity, and intestinal health of weaned piglets orally challenged with Escherichia coli K88

Cited by 19 publications

References 49 publications

Sodium Decanoate Improves Intestinal Epithelial Barrier and Antioxidation via Activating G Protein-Coupled Receptor-43

Sodium Decanoate Improves Intestinal Epithelial Barrier and Antioxidation via Activating G Protein-Coupled Receptor-43

Effect of Replacing in-Feed Antibiotic Growth Promoters with a Combination of Egg Immunoglobulins and Phytomolecules on the Performance, Serum Immunity, and Intestinal Health of Weaned Pigs Challenged with Escherichia coli K88

Dietary feed nanozeolite, Pediococcus, and medium-chain fatty acid enhanced growth performance and transcription of growth-related gene of Nile tilapia (Oreochromis niloticus)

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