Effects of misoprostol on human circulation

Brecht, Th.; Dengler, H. J.

doi:10.1016/0090-6980(87)90048-7

Cited by 25 publications

(11 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Data are not available for all women since not all items were completed. A significant difference was found only for shivering (P = 04001): in the misoprostol group 36/86 women (42%) indicated a score of 1 8 with five units of oxytocin; Sandoz Pharmaceuticals, Camberly, Surrey, UK) with five units of oxytocin, the use of Syntometrine was associated with a statistically significant reduction in the risk of postpartum haemor-rhageI4. This advantage was smaller but still significant when 10 units of oxytocin were used.…”

Section: Resultsmentioning

confidence: 94%

“…Both Syntometrine and methylergometrine should be stored between 243°C and require parenteral administration. Misoprostol was found to be active in the prevention of postpartum haemorrhage 9 but without clinically significant vasoactive properties 8 . Furthermore, it is orally active and stable at room temperature.…”

Section: Discussionmentioning

confidence: 99%

“…The use of prostaglandins in the postpartum period was first described in 1976 7 . Misoprostol has no clinically significant vasoactive properties in humans 8 and can be stored at room temperature. Recently, misoprostol, an oral prostaglandin E 1 analogue, was found to be effective in the prevention of postpartum haemorrhage 9 .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Misoprostol compared with methylergometrine for the prevention of postpartum haemorrhage: a double–blind randomised trial

Amant¹,

Spitz²,

Timmerman³

et al. 1999

BJOG

View full text Add to dashboard Cite

Objective To compare the efficacy and side effects of misoprostol, compared with methylergometrine, Design A double-blind, randomised clinical trial of 200 women with apparently normal pregnancies.Setting University teaching hospital.Participants Two hundred women with apparently normal pregnancies.Methods After the baby had been born, all women received two capsules by mouth and the contents of an ampule by intravenous injection. Each woman only received one active product. The capsules contained either a total of 600 pg misoprostol or placebo, and the ampule 200 pg of methylergometrine or placebo.Main outcome measures Need for further oxytocic drugs, blood pressure, the presence of side effects, mean haemoglobin and haematocrit three days after delivery.Results Two hundred women completed the study (100 received methylergometrine and 100 misoprostol). Postpartum haemorrhage occurred in 4.3% of the methylergometrine group and 8.3% of the misoprostol group ( P = 0.57). The need for further oxytocic drugs was 4.4% and 12.8% after methylergometrine and misoprostol, respectively (P = 0.065). One hour after the birth of the baby there was no difference in the mean systolic blood pressure (117 k 12 mmHg versus 115 f 11 mmHg) ( P = 0.26) or the mean diastolic blood pressure (72 k 10 mmHg versus 7 1 k 11 mmHg for the groups receiving methylergometrine or misoprostol, respectively) (P = 0.97). The mean temperature in the misoprostol group rose to 37.4"C, compared with 37°C in the methylergometrine group (P c 0.0001). In the misoprostol group 34% developed fever (> 38°C) compared with 3% in the methylergometrine group ( P < O~OOOl). Shivering (visual analogue score 2 8) also occurred more often after misoprostol (42%) than after methylergometrine (8.5%) (P c 0.0001). The haemoglobin level (g/dL) on the third postpartum day was similar for both groups (1 1 . O and 11.2 for methylergometrine and misoprostol, respectively) (P = 0.39).Conclusions This study suggests that although protection from postpartum haemorrhage using parenteral methylergometrine and oral misoprostol is nearly equal, misoprostol is associated with more side effects.for the prevention of postpartum haemorrhage.

show abstract

Section: Resultsmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Misoprostol compared with methylergometrine for the prevention of postpartum haemorrhage: a double–blind randomised trial

Amant¹,

Spitz²,

Timmerman³

et al. 1999

BJOG

View full text Add to dashboard Cite

show abstract

“…It is also effective after vaginal (20) or rectal administration (10) and has few side effects (9). In therapeutic dosages misoprostol has no clinically significant vasoactive properties in humans and does not cause hypertension (21,22). Extensive experience with misoprostol as an anti-ulcer agent indicates that it is a safe drug (23).…”

mentioning

confidence: 99%

A randomized, controlled trial comparing effect of oral misoprostol and intravenous syntocinon on intra-operative blood loss during cesarean section

Acharya

Al-Sammarai

Patel

et al. 2001

Acta Obstet Gynecol Scand

View full text Add to dashboard Cite

Acta Obstet Gynecol Scand 2001; 80: 245-250. C Acta Obstet Gynecol Scand 2001 Background. Oxytocics are routinely used in an attempt to prevent excessive blood loss during cesarean section. Misoprostol, a potent uterotonic agent, has been reported to be useful in the prevention and treatment of postpartum hemorrhage by several investigators but its use during cesarean section has not been described. The objective of this study was to randomly compare the effectiveness of oral misoprostol with intravenous syntocinon on blood loss during elective cesarean sections under regional anesthesia. Methods. Sixty pregnant women were randomized either to receive misoprostol 400 micrograms orally or syntocinon 10 IU intravenously during cesarean section. The primary outcome measure was intra-operative blood loss as estimated by physicians, and by values of preoperative and postoperative hemoglobin concentration and hematocrit. Demographic characteristics of the subjects and outcomes were compared using c-square test for categorical and two-sample t-test for continuous data. Results. Baseline characteristics in terms of age, body weight, parity, gestational age and indications for cesarean section were similar in both groups. The estimated blood loss was 545 ml (CI 476-614) in misoprostol group and 533 ml (CI 427-639) in syntocinon group (pΩ 0.85). Differences in preoperative and postoperative hemoglobin and hematocrit values were also similar in both groups. Two women in the misoprostol group and three in the syntocinon group (pΩ0.64) required additional oxytocics. One patient in each group required blood transfusion. No serious side effects were noted in either group. Conclusion. Oral misoprostol appears to be safe and as effective as intravenous syntocinon in reduction of intra-operative blood loss during elective cesarean section under regional anesthesia and merits further investigation.

show abstract

“…The agent is extensively absorbed and undergoes rapid conversion to misoprostol acid, the active chemical moiety. 9 In patients undergoing upper abdominal surgery, short-term intravenous lowdose infusions of PGE 1 produce significant reductions in mean arterial pressure (MAP) and increased urine output during surgery. 10 In patients who have diabetes mellitus with renal impairment, the combination of misoprostol with ibuprofen significantly increases glomerular filtration rate (GFR) and renal blood flow as compared with the acute effects of ibuprofen.…”

mentioning

confidence: 99%

Misoprostol Effects on Diclofenac‐Induced Cardiorenal Changes in Salt‐Sensitive Patients with Hypertension: The MEDIC Study

Munger

Gardner²,

Ateshkadi

et al. 2008

Pharmacotherapy

View full text Add to dashboard Cite

show abstract

Effects of misoprostol on human circulation

Cited by 25 publications

References 9 publications

Misoprostol compared with methylergometrine for the prevention of postpartum haemorrhage: a double–blind randomised trial

Misoprostol compared with methylergometrine for the prevention of postpartum haemorrhage: a double–blind randomised trial

A randomized, controlled trial comparing effect of oral misoprostol and intravenous syntocinon on intra-operative blood loss during cesarean section

Misoprostol Effects on Diclofenac‐Induced Cardiorenal Changes in Salt‐Sensitive Patients with Hypertension: The MEDIC Study

Contact Info

Product

Resources

About