Effects of Mindfulness-Based Stress Reduction on Blood Pressure, Mental Health, and Quality of Life in Hypertensive Adult Women: A Randomized Clinical Trial Study

Abstract

Background: Hypertension is one of the most important causes of cardiovascular diseases. Patients with hypertension have a lower quality of life. We aimed to evaluate the effects of mindfulness meditation on blood pressure, mental health, and quality of life in patients with hypertension. 
 Methods: This randomized clinical trial was performed in 2019 in Isfahan. Eighty adult women with Stage I or II hypertension were included and assigned randomly to 2 groups: 12 weeks of mindfulness-based stress reduction (MBSR) and routine care. At baseline and 1 week after the end of the intervention, blood pressure, stress, depression, anxiety, and quality of life of the studied participants were measured using the Depression, Anxiety, and Stress Scale-21 (DASS-21) and 36-Item Short Form Survey (SF-36) questionnaires. The data were analyzed using the independent t-test, the paired t-test, and the MANCOVA test.
 Results: After the intervention, the mean systolic and diastolic blood pressures decreased significantly in the intervention group compared with the baseline (142.82±11.01 mmHg vs 133.7±510.43 mmHg for systolic pressure and 86.12±8.24 mmHg vs 79.15±6.26 mmHg for diastolic pressure) and the control group (140.18±14.27 mmHg vs 142.15±10.23 mmHg for systolic pressure and 84.62± 9.22 vs mmHg 88.51±8.54 mmHg for diastolic pressure; P=0.001). There was also a significant increase in quality of life, stress, anxiety, and depression scores in the intervention group (P<0.05). 
 Conclusion: The 12-week MBSR program resulted in a significant reduction in the mean systolic and diastolic blood pressures and improvement in mental health and different aspects of quality of life.

The various role of microRNAs in breast cancer angiogenesis, with a special focus on novel miRNA-based delivery strategies

“…In atherosclerotic settings, down-regulation of miRNA-150 impairs angiogenesis and blood flow after ischemic tissue restoration, according to a recent study [159].…”

Literature Review the Effect of Mindfulness Interventions on Blood Pressure and Stress in Hypertension Patients

“…Every study included patient demographic information and baseline blood pressure measurements, which were evenly distributed between the treatment and control groups. All research participants were of diverse genders, with the exception of the studies conducted by Babak et al (2022) and Trancoso Lopes et al (2022), (Babak, et.al, 2022) and which only included female individuals. The participants’ age spanned from 45.8 to 60.3 years on average.…”

“…The study included individuals who were at least 18 years old and had hypertension, defined as having a systolic blood pressure of 180 mmHg or higher and/or a diastolic blood pressure of 80 mmHg or higher, with or without medication for hypertension. The average age in the intervention group was 48.67 ± 1.42 years, while in the control group it was 49.32 ± 2.31 years (P = 0.343) (Babak, Motamedi, Mousavi, & Darestani, 2022) with an average age of 45.8 ± 4.15 years (Trancoso Lopes et al, 2022).…”

“…According to the World Health Organization (WHO), around 250 million individuals are impacted by mental illness (Babak, Motamedi, Mousavi, & Ghasemi, 2022). Stress and worry have been linked to a higher likelihood of developing hypertension and experiencing cardiovascular events.…”

“…Effective blood pressure management is attained by less than 25% and 10% of individuals with hypertension in industrialized and underdeveloped nations, respectively (Lee et al, 2020) . Hence, there is a want for supplementary interventions aimed at diminishing blood pressure and stress levels Prior studies have extensively examined the efficacy of mindfulness interventions in reducing stress and blood pressure (Babak, Motamedi, Mousavi, & Darestani, 2022; Eunjoo An Michael R. Irwin Lynn V. Doering Mary-Lyn Brecht Karol E. Watson Elizabeth Corwin Paul M. Macey, 2021; Loucks et al, 2023a;Moceri & Cox, 2019b;Noventi et al, 2022;Polcari et al, 2022;Ponte Márquez et al, 2019;ŞEN GÖKÇEİMAM et al, 2022;Torné-Ruiz et al, 2023;Vara-García et al, 2019;Wright et al, 2021). These studies have reported a significant reduction in blood pressure and stress levels among participants who underwent mindfulness interventions, as compared to those in the control group.…”