Effects of Mindfulness-Based Interventions on Biomarkers and Low-Grade Inflammation in Patients with Psychiatric Disorders: A Meta-Analytic Review

Sanada, Kenji; Montero-Marín, Jesús; Barceló‐Soler, Alberto; Ikuse, Daisuke; Ota, M.; Hirata, Akihito; Yoshizawa, Akira; Hatanaka, Rieko; Valero, Montserrat Salas; Demarzo, Marcelo; Campayo, Javier García; Iwanami, Akira

doi:10.3390/ijms21072484

Cited by 55 publications

(44 citation statements)

References 80 publications

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“…This is supported by a previous meta-analysis, in which MBI, both exercise-MBI and meditation-MBI, show a significant correlation with clinical improvement. Concurrently, there is also a significant correlation with reduced inflammatory biomarkers, specifically salivary levels of interleukin 6 and tumor necrosis factor-alpha in depression and generalized anxiety disorder (Hofmann et al, 2010 ; Sanada et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Mindfulness-Based Intervention on Brain-Derived Neurotrophic Factor (BDNF): A Systematic Review and Meta-Analysis of Controlled Trials

et al. 2020

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Background: This systematic review aims to answer three questions. First, how much do mindfulness-based interventions (MBIs) affect peripheral brain-derived neurotrophic factor (BDNF)? Second, do mindfulness exercise-based interventions (exercise-MBIs) and mindfulness meditation-based interventions (meditation-MBIs) affect peripheral BDNF differently? Third, does the age of participants and the accumulative hours of MBI practice affect peripheral BDNF? Methods: We included randomized controlled trials comparing MBI and no intervention in adults (age >18 years) who reported peripheral BDNF. Database searches included PubMed, CINAHL, CENTRAL, PsyInfo, and Scopus. Two reviewers independently selected the studies and assessed the trial quality. We used the standardized mean difference (SMD) as the effect size index and conducted moderator analyses. Results: Eleven studies are included in this systematic review. Five studies applying exercise-MBI and three studies applying meditation-MBI are included in the meta-analysis (N = 479). The pooled effect size shows a significantly greater increase of peripheral BDNF in MBI groups compared to the control groups (k = 8, N = 479, SMD = 0.72, 95% CI 0.31-1.14, I 2 = 78%). Significantly more increases of BDNF in the MBI groups are found in both subgroups of exercise-MBI and meditation-MBI. The effect sizes of both subgroups are not significantly different between subgroups (χ 2 = 0.02, p = 0.88). We find no significant correlation between the effect sizes and the age of participants (r = −0.0095, p = 0.45) or accumulative hours of MBI practice (r = 0.0021, p = 0.57). Gomutbutra et al. Mindfulness and BDNF Meta-Analysis Conclusion: The heterogeneous data of this small sample-size meta-analysis suggests that MBI can increase peripheral BDNF. Either exercise-MBI or meditation-MBI can increase peripheral BDNF.

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Section: Discussionmentioning

confidence: 99%

The Effect of Mindfulness-Based Intervention on Brain-Derived Neurotrophic Factor (BDNF): A Systematic Review and Meta-Analysis of Controlled Trials

et al. 2020

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“…Based on the individual's awareness, attention and memory, mindfulness derives from some Buddhist concepts. This method allows full awareness and perception of the body and mind and helps reduce and eliminate negative emotions present in PTSD, considering that emotions depend on the mind itself, and not on external circumstances (48) . This therapy includes activities in a state of increased awareness, free of judgments, as seen in meditation (self-guided activity, with eyes closed, in a conscious state), transcendental meditation (meditation while listening to mantras), and mindfulness-based stretching exercises and deep breathing (mindfulness-based stretching and deep breathing exercise -MBX12 -a set of 12 fluid and connected movements).…”

Section: Discussionmentioning

confidence: 99%

“…This therapy includes activities in a state of increased awareness, free of judgments, as seen in meditation (self-guided activity, with eyes closed, in a conscious state), transcendental meditation (meditation while listening to mantras), and mindfulness-based stretching exercises and deep breathing (mindfulness-based stretching and deep breathing exercise -MBX12 -a set of 12 fluid and connected movements). These therapies act on thinking processes, with the patient in a vigilant hypometabolic state characterized by increased neural coherence and physiological rest, reducing cortisol, C-reactive protein, tumor necrosis factor alpha, triglycerides, heart rate, and blood pressure (32)(33)(34)48) .…”

Section: Discussionmentioning

confidence: 99%

Non-pharmacological therapies for the treatment of post-traumatic stress disorder among emergency responders: a scoping review

Nascimento

Santos

Dantas

et al. 2021

Rev. esc. enferm. USP

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Objective: Identify non-pharmacological therapies for the treatment of post-traumatic stress disorder in emergency responders. Method: Scope review according to the guidelines of the Joanna Briggs Institute and the PRISMA-ScR protocol. A search was conducted in nine databases, portals of theses and dissertations, and using an electronic search engine. Results: In total, 23 studies were selected and analyzed, and then categorized into six thematic fields - therapy with omega 3 food supplement, art therapy, physical exercise therapy, mindfulness-based therapy, therapy with elements of nature, and psychotherapy - which were considered non-pharmacological treatments for this psychopathology among emergency responders, as well as the use of psychotherapy via telehealth as an option for treatment. Conclusion: More evidence supporting diet therapy is required, while the other therapeutic options presented positive results, finding support in national and international recommendations of treatment and clinical practice.

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“…POU Class 2 Homeobox 1 ( POU2F1 ) has been implicated as a transcription factor located proximal to a SNP associated with emotional memory formation in PTSD (Wilker et al, 2018). IL6 has been associated with depression and anxiety as well (Crawford et al, 2018; Ryan et al, 2017; Sanada et al, 2020). The CpGs cg05616442 and cg18071894 in gene AKT Serine/Threonine Kinase 1 ( AKT1 ) showed highest importance score when looking at long and wide scores together.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Psychopathology, Social Adversity and Stress-relevant DNAm on Prospective Risk for Post-traumatic Stress: A Machine Learning Approach

Wani

Aiello

Kim

et al. 2020

Preprint

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BackgroundA range of factors have been identified that contribute to greater incidence, severity, and prolonged course of post-traumatic stress disorder (PTSD), including: comorbid and/or prior psychopathology; social adversity such as low socioeconomic position, perceived discrimination, and isolation; and biological factors such as genomic variation at glucocorticoid receptor regulatory network (GRRN) genes. This complex etiology and clinical course make identification of people at higher risk of PTSD challenging. Here we leverage machine learning (ML) approaches to identify a core set of factors that may together predispose persons to PTSD.MethodsWe used multiple ML approaches to assess the relationship among DNA methylation (DNAm) at GRRN genes, prior psychopathology, social adversity, and prospective risk for PTS severity (PTSS).ResultsML models predicted prospective risk of PTSS with high accuracy. The Gradient Boost approach was the top-performing model with mean absolute error of 0.135, mean square error of 0.047, root mean square error of 0.217, and R2 of 95.29%. Prior PTSS ranked highest in predicting the prospective risk of PTSS, accounting for >88% of the prediction. The top ranked GRRN CpG site was cg05616442, in AKT1, and the top ranked social adversity feature was loneliness.ConclusionMultiple factors including prior PTSS, social adversity, and DNAm play a role in predicting prospective risk of PTSS. ML models identified factors accounting for increased PTSS risk with high accuracy, which may help to target risk factors that reduce the likelihood or course of PTSD, potentially pointing to approaches that can lead to early intervention.

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Effects of Mindfulness-Based Interventions on Biomarkers and Low-Grade Inflammation in Patients with Psychiatric Disorders: A Meta-Analytic Review

Cited by 55 publications

References 80 publications

The Effect of Mindfulness-Based Intervention on Brain-Derived Neurotrophic Factor (BDNF): A Systematic Review and Meta-Analysis of Controlled Trials

The Effect of Mindfulness-Based Intervention on Brain-Derived Neurotrophic Factor (BDNF): A Systematic Review and Meta-Analysis of Controlled Trials

Non-pharmacological therapies for the treatment of post-traumatic stress disorder among emergency responders: a scoping review

The Impact of Psychopathology, Social Adversity and Stress-relevant DNAm on Prospective Risk for Post-traumatic Stress: A Machine Learning Approach

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