Effects of milk fat globule membrane and its various components on neurologic development in a postnatal growth restriction rat model

Brink, Lauren; Gueniot, Jordan P.; Lönnerdal, Bo

doi:10.1016/j.jnutbio.2019.03.013

Cited by 25 publications

(18 citation statements)

References 36 publications

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“…We wanted to assay the behavioral effects of polar lipid concentrates from BM and KO in an animal model of aging, providing low, nutritional doses and performing validated tests. Indeed, molecular biology data were supportive of our rationale [11,12] and data are accumulating on the effects of MFGMs on behavior and cognition [6,25,26]. We actually report minimal effects of those two formulations, whose doses were chosen to approximate human consumption [27].…”

Section: Discussionsupporting

confidence: 57%

Concentrates of buttermilk and krill oil improve cognition in aged rats

García-Serrano

Tomé‐Carneiro

Crespo

et al. 2020

Prostaglandins, Leukotrienes and Essential Fatty Acids

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Cognitive decline is one of the hallmarks of aging and can vary from mild cognitive. In addition to some lifestyle interventions, there is room for the use of nutraceuticals/functional food, as pharma-nutritional tools to lessen the burden of cognitive decline before it worsens. We previously reported the promising molecular actions of milk fat globule membranes rat model of aging. In this study, we concentrated on the activities on cognition, using an array of validated tests. We also performed lipidomic analyses of plasma, erythrocytes, and different brain areas. We report lower emotional memory (contextual fear conditioning) in aged rats supplemented with from buttermilk or krill oil at doses that approximate human consumption. No other behavioral parameter was significantly influenced by the supplements calling for further research to confirm or not the purported salubrious activities of polar lipids, namely those rich in n-3 long-chain polyunsaturated fatty acids on cognitive decline.

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Section: Discussionsupporting

confidence: 57%

Concentrates of buttermilk and krill oil improve cognition in aged rats

García-Serrano

Tomé‐Carneiro

Crespo

et al. 2020

Prostaglandins, Leukotrienes and Essential Fatty Acids

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“…For example, an infant formula containing MFGM improved the reflex development and altered the brain lipid composition in rats with a pup-in-a-cup model more similarly to mother's milk [121]. MFGM in formula has also been reported to improve T-Maze scores in growth-restricted rats [122], improve stress-induced disruptions in rapid eye movement (REM) sleep [123], and improve infant scores using the Bayles Scale of Infant Development [124]. Combining MFGM with other bioactive ingredients, such as probiotics, may provide additional benefits throughout development, although the mechanisms have not yet been fully elucidated.…”

Section: Neurodevelopment and Cognitive Functionmentioning

confidence: 99%

Improving Human Health with Milk Fat Globule Membrane, Lactic Acid Bacteria, and Bifidobacteria

et al. 2021

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The milk fat globule membrane (MFGM), the component that surrounds fat globules in milk, and its constituents have gained significant attention for their gut function, immune-boosting properties, and cognitive-development roles. The MFGM can directly interact with probiotic bacteria, such as bifidobacteria and lactic acid bacteria (LAB), through interactions with bacterial surface proteins. With these interactions in mind, increasing evidence supports a synergistic effect between MFGM and probiotics to benefit human health at all ages. This important synergy affects the survival and adhesion of probiotic bacteria through gastrointestinal transit, mucosal immunity, and neurocognitive behavior in developing infants. In this review, we highlight the current understanding of the co-supplementation of MFGM and probiotics with a specific emphasis on their interactions and colocalization in dairy foods, supporting in vivo and clinical evidence, and current and future potential applications.

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“…phospholipid concentrate and sialic acid (Brink et al . 2019). This was explained by higher upregulation of genes and better improvement of T‐maze scores in the MFGM‐fed group than the sialic acid group.…”

Section: Nutritional and Health Benefits Of Mfgmmentioning

confidence: 99%

Milk fat globule membrane: An overview with particular emphasis on its nutritional and health benefits

El-Salam

El-Shibiny

2020

Int J of Dairy Tech

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Milk fat globule membrane (MFGM) is a minor milk constituent composed of a large number of polar lipid (PL) classes and proteins organised in a tri-layer structure. The MFGM PLs and proteins have a wide range of nutritional and health benefits. Animal and human studies have shown that consumption of MFGM preparations has beneficial effects on brain development and function and physical performance, particularly in the elderly. MFGM also improves intestinal health and skin condition, combats hypercholesterolaemia, obesity and inflammation. The present article updates the information about MFGM; particularly its nutritional and health benefits.

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Effects of milk fat globule membrane and its various components on neurologic development in a postnatal growth restriction rat model

Cited by 25 publications

References 36 publications

Concentrates of buttermilk and krill oil improve cognition in aged rats

Concentrates of buttermilk and krill oil improve cognition in aged rats

Improving Human Health with Milk Fat Globule Membrane, Lactic Acid Bacteria, and Bifidobacteria

Milk fat globule membrane: An overview with particular emphasis on its nutritional and health benefits

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