Effects of milk-based phospholipids on cognitive performance and subjective responses to psychosocial stress: A randomized, double-blind, placebo-controlled trial in high-perfectionist men

Boyle, Neil B.; Dye, Louise; Arkbåge, Karin; Thorell, Lars‐Håkan; Frederiksen, Pernille; Croden, Fiona; Lawton, Clare

doi:10.1016/j.nut.2018.05.002

Cited by 20 publications

(14 citation statements)

References 69 publications

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“…Animal-based foods, such as camembert cheese, worsened cognition, even when levels of the neuroprotective BDNF were high [38], but, in contrast, intake of bovine milk-derived phospholipid was shown to protect cognitive performance under stress in terms of better sustained attention. Taken together, the effects of phospholipid supplementation may be limited to subjects with high levels of stress, as they attenuate stress response mediated by the HPA axis [80].…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, two other RCTs were conducted in cognitively normal participants. A 6-week parallel RCT in 54 high-perfectionist men showed the consumption of milk protein concentrate drink enriched with phospholipids, sphingomyelin, phosphatidylcholine and phosphatidylethanolamine (250 mL/d with 2.7 g of phospholipids) enhanced performance on switch attention task [80]; while 33 elderly nursing home residents allocated to receive medium-chain triglycerides (6 g/d) either alone or in combination with L-Leucine (1.2 g/d) and cholecalciferol (20 µg/d) for 3 months significantly improved their cognition compared to the control group (6 tg/d long-chain triglycerides) [81]. Other studies with different dietary supplements or their combinations have also evaluated their potential beneficial role on cognition in subjects with subjective cognitive decline.…”

Section: Other Types Of Dietary Supplements (N = 15)mentioning

confidence: 99%

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Effects of Nutrition on Cognitive Function in Adults with or without Cognitive Impairment: A Systematic Review of Randomized Controlled Clinical Trials

et al. 2021

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New dietary approaches for the prevention of cognitive impairment are being investigated. However, evidence from dietary interventions is mainly from food and nutrient supplement interventions, with inconsistent results and high heterogeneity between trials. We conducted a comprehensive systematic search of randomized controlled trials (RCTs) published in MEDLINE-PubMed, from January 2018 to July 2021, investigating the impact of dietary counseling, as well as food-based and dietary supplement interventions on cognitive function in adults with or without cognitive impairment. Based on the search strategy, 197 eligible publications were used for data abstraction. Finally, 61 articles were included in the analysis. There was reasonable evidence that dietary patterns, as well as food and dietary supplements improved cognitive domains or measures of brain integrity. The Mediterranean diet showed promising results, whereas the role of the DASH diet was not clear. Healthy food consumption improved cognitive function, although the quality of these studies was relatively low. The role of dietary supplements was mixed, with strong evidence of the benefits of polyphenols and combinations of nutrients, but with low evidence for PUFAs, vitamin D, specific protein, amino acids, and other types of supplements. Further well-designed RCTs are needed to guide the development of dietary approaches for the prevention of cognitive impairment.

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Section: Discussionmentioning

confidence: 99%

Section: Other Types Of Dietary Supplements (N = 15)mentioning

confidence: 99%

Effects of Nutrition on Cognitive Function in Adults with or without Cognitive Impairment: A Systematic Review of Randomized Controlled Clinical Trials

et al. 2021

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“…Highly perfectionist men were enrolled in a randomised, double‐blind, placebo‐controlled trial to test the effect of milk‐based phospholipids on their cognitive performance and subjective responses to psychosocial stress (Boyle et al . 2019). The dietary supplement conferred a beneficial effect on cognitive performance under conditions of psychosocial stress but failed to moderate the cortisol response.…”

Section: Nutritional and Health Benefits Of Mfgmmentioning

confidence: 99%

Milk fat globule membrane: An overview with particular emphasis on its nutritional and health benefits

El-Salam

El-Shibiny

2020

Int J of Dairy Tech

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Milk fat globule membrane (MFGM) is a minor milk constituent composed of a large number of polar lipid (PL) classes and proteins organised in a tri-layer structure. The MFGM PLs and proteins have a wide range of nutritional and health benefits. Animal and human studies have shown that consumption of MFGM preparations has beneficial effects on brain development and function and physical performance, particularly in the elderly. MFGM also improves intestinal health and skin condition, combats hypercholesterolaemia, obesity and inflammation. The present article updates the information about MFGM; particularly its nutritional and health benefits.

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“…L-serine is essential for the synthesis of sphingolipids and phosphatidylserine (PS) in particular types of central nervous system neurons (Hirabayashi and Furuya, 2008). Additionally, the cognitive performance benefits of dietary milk phospholipid have been evidenced with the clinical trial (Boyle et al, 2019), the rats model (Schipper et al, 2016), and the piglet model as well (Liu et al, 2014). Present results appertaining the cognitive functions of milk phospholipids, from either ex vivo models or in vivo models are illustrated in Table 5.…”

Section: Neurocognitive Effectsmentioning

confidence: 84%

Vesicle properties and health benefits of milk phospholipids: a review

Huang¹,

Zhao²,

Guan³

et al. 2019

JFB

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Phospholipids are important ingredients in milk. They serve as bioactive components with processing functionalities, despite representing only a small proportion of total milk lipids. There has been increasing interest in vesicle properties and health effects of milk phospholipids. However, there are limited reports on industry-scale manufacturing of related commercial products. This contribution aims to elucidate the industrial processes of manufacturing milk phospholipid products including phospholipid extraction and fraction as well as summarizing determination assays of milk phospholipids. In addition to industrial production, this review elaborates on application aspects, such as the biological properties of milk phospholipids and their technical importance as delivery vesicles of liposomes and phytosomes. In addition, new insights on large-scale production of milk phospholipids and new applications such as phytosomes and antioxidant properties are discussed.

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Effects of milk-based phospholipids on cognitive performance and subjective responses to psychosocial stress: A randomized, double-blind, placebo-controlled trial in high-perfectionist men

Abstract: Dietary intake of bovine milk PLs conferred cognitive performance benefit under conditions of psychosocial stress but failed to moderate cortisol response. Moderation of subjective response to stress exposure may have underpinned this performance protection.

Cited by 20 publications

References 69 publications

Effects of Nutrition on Cognitive Function in Adults with or without Cognitive Impairment: A Systematic Review of Randomized Controlled Clinical Trials

Effects of Nutrition on Cognitive Function in Adults with or without Cognitive Impairment: A Systematic Review of Randomized Controlled Clinical Trials

Milk fat globule membrane: An overview with particular emphasis on its nutritional and health benefits

Vesicle properties and health benefits of milk phospholipids: a review

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