Effects of mild processing pressures on the performance of dry powder inhaler formulations for inhalation therapy (1): Budesonide and lactose

Marek, Steve R.; Donovan, Martín J.

doi:10.1016/j.ejpb.2010.12.020

Cited by 8 publications

(7 citation statements)

References 21 publications

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“…Air-jet milling is considered a batch manufacturing process where batch size and batch-to-batch variability may significantly influence physicochemical characteristics of milled powders (Lee et al, 2015). Additionally, powder handling may affect these characteristics within a single batch (Marek et al, 2011). Even though these changes may not be detectable with standard characterization methods, they may affect performance of DPIs during formulations (Ticehurst et al, 1994).…”

Section: Introductionmentioning

confidence: 99%

Carrier-free high-dose dry powder inhaler formulation of ibuprofen: Physicochemical characterization and in vitro aerodynamic performance

Yazdi

2016

International Journal of Pharmaceutics

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Section: Introductionmentioning

confidence: 99%

Carrier-free high-dose dry powder inhaler formulation of ibuprofen: Physicochemical characterization and in vitro aerodynamic performance

Yazdi

2016

International Journal of Pharmaceutics

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“…[10][11][12] In our previous work, molecular coupling agents, such as macromolecule BA-MAA-AN, BA-MMA-VTES were synthesized to modify nanosized silicon nitride (Si 3 N 4 ), which was applied to prepare nanoparticles=NBR composites. The results show, via modification, an organic coating layer formed on the surface of nano-Si 3 N 4 powder and a chemical bond combination happens between BA-MAA-AN tercopolymer and nano-Si 3 N 4 powder surface.…”

Section: Introductionmentioning

confidence: 99%

Study of Surface Modification of Nanosize Si₃N₄with Macromolecular Coupling Agent LMPB-g-GMA in Different Solvents

Wei

Qian

Miao

et al. 2012

Journal of Dispersion Science and Technology

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A new macromolecular coupling agent, low-molecular-weight polybutadiene liquid rubber (LMPB)-glycidyl methacrylate (GMA), was synthesized using solution polymerization initiated by benzoyl peroxide (BPO). The molecular structure was confirmed by FTIR and NMR. This macromolecular LMPB-GMA was used for surface modification of silicon nitride (Si 3 N 4 ) nanopowder in n-heptane, chloroform, ethyl acetate, and DMF, respectively. LMPB-GMA and modified nano-Si 3 N 4 were systematically investigated by FTIR, NMR, TGA, and TEM. The results showed that LMPB-GMA bonded and formed an organic coating layer onto the surface of nanosized Si 3 N 4 particles. The polarity of the solvents plays an important role in this process. Strong or weak polar both affect the results. The dosage loading of LMPB-GMA is 12 wt% of nanosized Si 3 N 4 . Nanosized Si 3 N 4 modified in ethyl acetate has better dispersibility and stability than that modified in n-heptane or DMF. TEM pictures also reveal that modified nano-Si 3 N 4 possesses good dispersibility.

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“…Empirical observations and theoretical models for drug aerosolization in these systems are complicated by the plethora of physico-chemical variables of the carrier. For example, carrier roughness,[ 10 11 ] carrier shapes,[ 11 ] surface energy,[ 12 ] and mild compression force[ 13 ] are variables that have been shown to influence aerosol performance. Inevitably the study of one physico-chemical property in isolation is difficult, since the modification of one variable generally results in a change in other variables in the system such as changing carrier size alters roughness or changing polymorphic form alters surface chemistry and shape.…”

Section: Introductionmentioning

confidence: 99%

Effect of compression pressure on inhalation grade lactose as carrier for dry powder inhalations

Raut¹,

Jamaiwar²,

Umekar³

et al. 2016

Int J Pharma Investig

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Introduction:This study focused on the potential effects of compression forces experienced during lactose (InhaLac 70, 120, and 230) storage and transport on the flowability and aerosol performance in dry powder inhaler formulation.Materials and Methods:Lactose was subjected to typical compression forces 4, 10, and 20 N/cm2. Powder flowability and particle size distribution analysis of un-compressed and compressed lactose was evaluated by Carr's index, Hausner's ratio, the angle of repose and by laser diffraction method. Aerosol performance of un-compressed and compressed lactose was assessed in dispersion studies using glass twin-stage-liquid-impenger at flow rate 40-80 L/min.Results:At compression forces, the flowability of compressed lactose was observed same or slightly improved. Furthermore, compression of lactose caused a decrease in in vitro aerosol dispersion performance.Conclusion:The present study illustrates that, as carrier size increases, a concurrent decrease in drug aerosolization performance was observed. Thus, the compression of the lactose fines onto the surfaces of the larger lactose particles due to compression pressures was hypothesized to be the cause of these observed performance variations. The simulations of storage and transport in an industrial scale can induce significant variations in formulation performance, and it could be a source of batch-to-batch variations.

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Effects of mild processing pressures on the performance of dry powder inhaler formulations for inhalation therapy (1): Budesonide and lactose

Cited by 8 publications

References 21 publications

Carrier-free high-dose dry powder inhaler formulation of ibuprofen: Physicochemical characterization and in vitro aerodynamic performance

Carrier-free high-dose dry powder inhaler formulation of ibuprofen: Physicochemical characterization and in vitro aerodynamic performance

Study of Surface Modification of Nanosize Si₃N₄with Macromolecular Coupling Agent LMPB-g-GMA in Different Solvents

Effect of compression pressure on inhalation grade lactose as carrier for dry powder inhalations

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Effects of mild processing pressures on the performance of dry powder inhaler formulations for inhalation therapy (1): Budesonide and lactose

Cited by 8 publications

References 21 publications

Carrier-free high-dose dry powder inhaler formulation of ibuprofen: Physicochemical characterization and in vitro aerodynamic performance

Carrier-free high-dose dry powder inhaler formulation of ibuprofen: Physicochemical characterization and in vitro aerodynamic performance

Study of Surface Modification of Nanosize Si3N4with Macromolecular Coupling Agent LMPB-g-GMA in Different Solvents

Effect of compression pressure on inhalation grade lactose as carrier for dry powder inhalations

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Study of Surface Modification of Nanosize Si₃N₄with Macromolecular Coupling Agent LMPB-g-GMA in Different Solvents