Effects of microRNA-221/222 on cell proliferation and apoptosis in prostate cancer cells

Wang, Lina; Liu, Chunyan; Li, Chaoyang; Xue, Jing; Zhao, Shihu; Zhan, Panpan; Lin, Yani; Zhang, Pengju; An-li, Jiang; Chen, Weiwen

doi:10.1016/j.gene.2015.07.017

Cited by 52 publications

(34 citation statements)

References 32 publications

(31 reference statements)

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“…Recently, many studies have demonstrated that deregulation of miRNAs can affect cell cycle control, apoptosis, invasion, migration, and resistance to chemotherapy and radiotherapy of gliomas [15–21]. Some miRNAs have been identified as oncomiRs [15,16], whereas others have been identified as tumor-suppressor miRNAs [17–19]. Studies have showed that miRNAs also involved in ROS regulation in many types of cancers.…”

Section: Introductionmentioning

confidence: 99%

MiR-9-3p augments apoptosis induced by H2O2 through down regulation of Herpud1 in glioma

Yang

Cui

et al. 2017

PLoS ONE

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MicroRNAs are short, single-stranded non-coding RNA molecules that function as regulators of tumor progression in various cancers, including glioma. The present study sought to investigate the biological functions of miR-9-3p in glioma progression. The results of a microRNA microarray indicated that microRNA-9-3p (miR-9-3p, miR-9*) is down-regulated in high-grade (grades III and IV) gliomas compared with non-tumor tissues. These results were confirmed with real-time PCR. The miR-9-3p expression level was associated with age and tumor grade. Herpud1 was regulated by miR-9-3p in glioma cells and tissues and was identified as a miR-9-3p target with luciferase reporter assays. Glioma cells transfected with miR-9-3p mimics or HERPUD1-RNAi had more apoptotic cells than them in control after induced by H2O2. Our results indicated that low expression of miR-9-3p results in a high level of Herpud1, which may protect against apoptosis in glioma.

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Section: Introductionmentioning

confidence: 99%

MiR-9-3p augments apoptosis induced by H2O2 through down regulation of Herpud1 in glioma

Yang

Cui

et al. 2017

PLoS ONE

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“…39 The miR-221/222 cluster is also reported to promote cell proliferation and repress apoptosis thorough suppressing caspase-10. 40 However, genome-wide miRNA expression signatures using clinical PCa and CRPC specimens showed significant downregulation of the miR-221/222 cluster compared with normal prostate tissues, suggesting these miRNAs function as tumor suppressors in PCa patients, especially in CRPC. 10,12,13, [41][42][43][44][45] These comprehensive approaches to miRNA expression in clinical specimens would help identify novel functional mechanisms of miRNAs.…”

Section: Mirnas Associated With Cell Proliferation and Apoptosis In Pcamentioning

confidence: 97%

The roles of microRNAs in the progression of castration-resistant prostate cancer

2016

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Prostate cancer (PCa) is one of the leading causes of cancer-related death in men. PCa is androgen-dependent, and androgen-deprivation therapy is effective for first-line hormonal treatment, but the androgen-independent phenotype of PCa eventually develops, which is difficult to treat and has no effective cure. Recently, microRNAs have been discovered to have important roles in the initiation and progression of PCa, suggesting their use in diagnosis, predicting prognosis and development of treatment for castration-resistant PCa (CRPC). Understanding the networks of microRNAs and their target genes is necessary to ascertain their roles and importance in the development and progression of PCa. This review summarizes the current knowledge about microRNAs regulating PCa progression and elucidates the mechanism of progression to CRPC.

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“…miR-185 is a tsmiR reduced in clinical PCa samples that downregulates AR (Qu et al 2013, Liu et al 2015a). Overexpression of miR-185 reduced AR expression and inhibited LNCaP cell proliferation arresting cells at G1 phase and inducing apoptosis.…”

Section: Mir-185mentioning

confidence: 99%

Implications of microRNA dysregulation in the development of prostate cancer

et al. 2017

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MicroRNAs (miRNAs) are non-coding small RNAs that target mRNA to reduce protein expression. They play fundamental roles in several diseases, including prostate cancer (PCa). A single miRNA can target hundreds of mRNAs and coordinately regulate them, which implicates them in nearly every biological pathway. Hence, miRNAs modulate proliferation, cell cycle, apoptosis, adhesion, migration, invasion and metastasis, most of them constituting crucial hallmarks of cancer. Due to these properties, miRNAs emerged as promising tools for diagnostic, prognosis and management of cancer patients. Moreover, they come out as potential targets for cancer treatment, and several efforts are being made to progress in the field of miRNA-based cancer therapy. In this review, we will summarize the recent information about miRNAs in PCa. We will recapitulate all the miRNAs involved in the androgen pathway and the biology of PCa, focusing in PCa initiation and progression. In particular, we will describe the miRNAs associated with cell proliferation, cell cycle and apoptosis in PCa, as well as invasion, adhesion and metastatic miRNAs. We will revise the recent progress made understanding the role of circulating miRNAs identified in PCa that might be useful for PCa patient stratification. Another key aspect to be discussed in this review is miRNAs' role in PCa therapy, including the miRNAs delivery.Reproduction (2017) 154 R81-R97

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Effects of microRNA-221/222 on cell proliferation and apoptosis in prostate cancer cells

Cited by 52 publications

References 32 publications

MiR-9-3p augments apoptosis induced by H2O2 through down regulation of Herpud1 in glioma

MiR-9-3p augments apoptosis induced by H2O2 through down regulation of Herpud1 in glioma

The roles of microRNAs in the progression of castration-resistant prostate cancer

Implications of microRNA dysregulation in the development of prostate cancer

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