Effects of microneedle length, density, insertion time and multiple applications on human skin barrier function: Assessments by transepidermal water loss

Gomaa, Yasmine; Morrow, Desmond I. J.; Garland, Martin J.; Donnelly, Ryan F.; El-Khordagui, Labiba K.; Meidan, Victor M.

doi:10.1016/j.tiv.2010.08.012

Cited by 102 publications

(66 citation statements)

References 21 publications

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“…There is also an interplay of the effect of these variables and, as such, their effects on the permeation of a drug molecule are generally non-intuitive. As a result, their effects are best studied for specific case 15,16 .…”

Section: Introductionmentioning

confidence: 99%

Microneedle-assisted transdermal delivery of Zolmitriptan: effect of microneedle geometry, in vitro permeation experiments, scaling analyses and numerical simulations

Uppuluri

Devineni

Han

et al. 2017

Drug Development and Industrial Pharmacy

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Section: Introductionmentioning

confidence: 99%

Microneedle-assisted transdermal delivery of Zolmitriptan: effect of microneedle geometry, in vitro permeation experiments, scaling analyses and numerical simulations

Uppuluri

Devineni

Han

et al. 2017

Drug Development and Industrial Pharmacy

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“…Transdermal permeation enhancement of drugs using microneedle technology is a complex phenomenon and it has been reported in the literature that several geometric parameters of MNs like shape, dimensions, density of MN on the device and type etc. play important roles in enhancing the transdermal permeation of drugs [17]. There is also interplay of the effect of these variables and, as such, their effects on the permeation of a drug molecule are generally non-intuitive.…”

Section: Introductionmentioning

confidence: 99%

Effect of microneedles on transdermal permeation enhancement of amlodipine

Nalluri

Uppuluri

Devineni

et al. 2017

Drug Deliv. and Transl. Res.

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“…In order to carry out simulation studies of high accuracy, the relative ability of the MNs in creating microconduits in the skin should be understood precisely. It is well known now that owing to the viscoelastic nature of the skin, the microconduits created do not have the same dimensions as the MN, but may vary significantly (8,19), thereby limiting the applicability of MN design parameters to carry out such simulations. Microphotographs of histological sections can provide an efficient way of predicting the extent of skin disruption by different MNs, which may be used to develop accurate simulations of the drug(s) permeation process (14).…”

Section: Discussionmentioning

confidence: 99%

Application of Microneedle Arrays for Enhancement of Transdermal Permeation of Insulin: In Vitro Experiments, Scaling Analyses and Numerical Simulations

et al. 2015

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Abstract. The aim of this investigation is to study the effect of donor concentration and microneedle (MN) length on permeation of insulin and further evaluating the data using scaling analyses and numerical simulations. Histological evaluation of skin sections was carried to evaluate the skin disruption and depth of penetration by MNs. Scaling analyses were done using dimensionless parameters like concentration of drug (C t /C s ), thickness (h/L) and surface area of the skin (S a /L 2 ). Simulation studies were carried out using MATLAB and COMSOL software to simulate the insulin permeation using histological sections of MN-treated skin and experimental parameters like passive diffusion coefficient. A 1.6-fold increase in transdermal flux and 1.9-fold decrease in lag time values were observed with 1.5 mm MN when compared with passive studies. Good correlation (R 2 >0.99) was observed between different parameters using scaling analyses. Also, the in vitro and simulated permeations profiles were found to be similar (f 2 ≥50). Insulin permeation significantly increased with increase in donor concentration and MN length (p<0.05). The developed scaling correlations and numerical simulations were found to be accurate and would help researchers to predict the permeation of insulin with new dimensions of MN in optimizing insulin delivery. Overall, it can be inferred that the application of MNs can significantly enhance insulin permeation and may be an efficient alternative for injectable insulin therapy in humans.

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Effects of microneedle length, density, insertion time and multiple applications on human skin barrier function: Assessments by transepidermal water loss

Cited by 102 publications

References 21 publications

Microneedle-assisted transdermal delivery of Zolmitriptan: effect of microneedle geometry, in vitro permeation experiments, scaling analyses and numerical simulations

Microneedle-assisted transdermal delivery of Zolmitriptan: effect of microneedle geometry, in vitro permeation experiments, scaling analyses and numerical simulations

Effect of microneedles on transdermal permeation enhancement of amlodipine

Application of Microneedle Arrays for Enhancement of Transdermal Permeation of Insulin: In Vitro Experiments, Scaling Analyses and Numerical Simulations

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