Effects of microgravity on DNA damage response in Caenorhabditis elegans during Shenzhou-8 spaceflight

Gao, Ying; Xu, Dan; Zhao, Lei; Zhang, Min; Sun, Yeqing

doi:10.3109/09553002.2015.1043754

Cited by 29 publications

(22 citation statements)

References 72 publications

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“…For instance, a study on Caenorhabditis elegans showed that several DDR genes were differentially expressed during the 16.5-day Shenzhou-8 space mission, suggesting possible enhanced DDR under microgravity. 48 Overall, most of these studies suggest no effect of space flight on the DDR (Table 2). …”

Section: Spaceflight Studiesmentioning

confidence: 99%

Interplay of space radiation and microgravity in DNA damage and DNA damage response

et al. 2017

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In space, multiple unique environmental factors, particularly microgravity and space radiation, pose constant threat to the DNA integrity of living organisms. Specifically, space radiation can cause damage to DNA directly, through the interaction of charged particles with the DNA molecules themselves, or indirectly through the production of free radicals. Although organisms have evolved strategies on Earth to confront such damage, space environmental conditions, especially microgravity, can impact DNA repair resulting in accumulation of severe DNA lesions. Ultimately these lesions, namely double strand breaks, chromosome aberrations, micronucleus formation, or mutations, can increase the risk for adverse health effects, such as cancer. How spaceflight factors affect DNA damage and the DNA damage response has been investigated since the early days of the human space program. Over the years, these experiments have been conducted either in space or using ground-based analogs. This review summarizes the evidence for DNA damage induction by space radiation and/or microgravity as well as spaceflight-related impacts on the DNA damage response. The review also discusses the conflicting results from studies aimed at addressing the question of potential synergies between microgravity and radiation with regard to DNA damage and cellular repair processes. We conclude that further experiments need to be performed in the true space environment in order to address this critical question.

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Section: Spaceflight Studiesmentioning

confidence: 99%

Interplay of space radiation and microgravity in DNA damage and DNA damage response

et al. 2017

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“…A multitude of other biological processes that are affected include increased genomic instability and mutation rates [17], immune dysregulation [18], and deregulated cellular energetics [19]. Conflicting results on cellular stemness [20] have been reported with effects such as elongation of telomere and altered telomerase function that require clarification [21,22].A substantial amount of work has also been generated in the area of omics. For several decades, omics animal-based studies have been performed to understand the human health risks due to spaceflight missions using the International Space Station, the space shuttle, biosatellites, and ground-based experiments.…”

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confidence: 99%

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confidence: 99%

NASA GeneLab Platform Utilized for Biological Response to Space Radiation in Animal Models

McDonald¹,

Stainforth

Cahill

et al. 2020

Cancers

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Background: Ionizing radiation from galactic cosmic rays (GCR) is one of the major risk factors that will impact the health of astronauts on extended missions outside the protective effects of the Earth’s magnetic field. The NASA GeneLab project has detailed information on radiation exposure using animal models with curated dosimetry information for spaceflight experiments. Methods: We analyzed multiple GeneLab omics datasets associated with both ground-based and spaceflight radiation studies that included in vivo and in vitro approaches. A range of ions from protons to iron particles with doses from 0.1 to 1.0 Gy for ground studies, as well as samples flown in low Earth orbit (LEO) with total doses of 1.0 mGy to 30 mGy, were utilized. Results: From this analysis, we were able to identify distinct biological signatures associating specific ions with specific biological responses due to radiation exposure in space. For example, we discovered changes in mitochondrial function, ribosomal assembly, and immune pathways as a function of dose. Conclusions: We provided a summary of how the GeneLab’s rich database of omics experiments with animal models can be used to generate novel hypotheses to better understand human health risks from GCR exposures.

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“…例如, Kiefer和Pross [104] 综述了在微重力条件下辐射诱导 DNA损伤的修复过程, 认为其并不受微重力条件的影响. 在已有的研究结果中, 微重力对空间辐射诱导的 DNA损伤响应分别产生了增加、减弱以及无影响等3 种不同的结果 [105,106] . 经验模型和统计模型, 如King模型 [107] 、JPL模型 [108] 、 ESP模型 [109] 等, 进行SPE的预报, 但实际的预报中误报率(false alarm rate, FAR)一直偏高.…”

Section: 而在Nasa的方法中实体癌Ddref被认为服从对数unclassified

Issues and challenges of space radiation risk assessment in manned deep space exploration missions

Zhao¹,

Dong²,

Sun³

2018

Chin. Sci. Bull.

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Effects of microgravity on DNA damage response in Caenorhabditis elegans during Shenzhou-8 spaceflight

Abstract: Evidence was provided that, in the presence of space radiations, microgravity probably enhanced the DNA damage response in C. elegans by integrating the transcriptome and microRNome.

Cited by 29 publications

References 72 publications

Interplay of space radiation and microgravity in DNA damage and DNA damage response

Interplay of space radiation and microgravity in DNA damage and DNA damage response

NASA GeneLab Platform Utilized for Biological Response to Space Radiation in Animal Models

Issues and challenges of space radiation risk assessment in manned deep space exploration missions

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