Abstract:Experiments mimicking microgravity condition have multiple effects on cardiac electrophysiology. Therefore, based on experimental data of rats with 2-weeks (short term) and 4-weeks (long term) tail suspension, effect of microgravity on action potentials (APs) were simulated by decreasing I CaL and increasing I NaK based on rat endocardial and epicardial models. Additionally, a 1D model was constructed by considering the increasing of connexin 43 under microgravity condition. Simulation results show that I CaL … Show more
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