Effects of Microdesmis keayana roots on sexual behavior of male rats

Zamblé, Alexis; Şahpaz, Sevser; Brunet, C.; Bailleul, François

doi:10.1016/j.phymed.2007.10.002

Cited by 34 publications

(29 citation statements)

References 13 publications

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“…These bioactive agents exhibit aphrodisiac activity either by increasing the biosynthesis and secretion of androgens or act directly on the central nervous system to modulate the action of neurotransmitters and gonadal tissues in animals. Specifically, saponins enhance androgen production (Gauthaman et al, 2002) whereas alkaloids may increase the dilation of blood vessels in the sexual organs (Perbot, 1982), or increase nitric oxide that plays a key role in central erection and central sexual stimulation (Zamble et al, 2008). Interestingly, some of these phytochemicals such as saponins and steroids were also detected in the seed extract in this study; it is possible that the extract lacked the specific type.…”

Section: Discussionmentioning

confidence: 81%

“…Immediately after their respective administration (T = 0), the animals were allowed an acclimatization period of 15 min. A non-oestrous female was introduced into the plastic cage (T = 15 min), in ratio 1:1 and sexual behavioural parameters were then monitored for observatory periods of first (15-30 min), second (75-90 min), and third (180-195 min) after administering the extract (Ramachandran et al, 2004; Zamble et al, 2008). Adopting the standard procedures described by Amin et al (1996) and Agmo (1997), the male sexual behaviour indices monitored during the three observatory periods included: MF (the number of mounts from the time of introduction of the female until ejaculation), IF, (the number of intromissions from the time of introduction of the female until ejaculation), GTF (number of times the male rat cleaned up the tip of the copulatory organ), EF (the number of times semen was ejected from the male copulatory organ), ML (the time interval between the introduction of the female and the first mount by the male), IL (the time interval between the introduction of the female and the first intromission by the male) and EL (the time interval between the first intromission and ejaculation).…”

Section: Animal Grouping Extract Administration and Monitoring Of Sementioning

confidence: 99%

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<em>Garcinia Kola</em> Seeds: Is the Aqueous Extract a True Aphrodisiac in Male Wistar Rats?

Yakubu¹,

Quadri²

2012

Afr. J. Trad. Compl. Alt. Med.

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The age long acclaimed aphrodisiac potentials of Garcinia kola seeds in some parts of Western Nigeria has not been substantiated with scientific evidence. In this study, we have decided to evaluate the effect of aqueous seed extract of G. kola at the doses of 25, 50 and 100 mg/kg body weight on sexual behaviour of male rats. Male rats weighing 215.00 ± 18.58 g were randomized completely into four groups (A-D) of six animals each. Animals in group A received, orally, 0.5 ml of distilled water only while those in groups B, C and D received same volume containing 25, 50 and 100 mg/kg body weight of the seed extract respectively. Frequencies of mount (MF), intromission (IF), genital toilet (GTF) and ejaculation (EF) as well as latencies of mount (ML), intromission (IL) and ejaculation (EL) were evaluated following the pairing of male rats (1:1) with non-oestrous female rats. The parameters were monitored for the first (15-30 min), second (75-90 min) and third (180-195 min) observatory periods. The levels of testosterone, luteinizing (LH) and follicle stimulating hormones (FSH) were also determined. Phytochemical screening of the extract revealed the presence of saponins (2.78%), cardiac glycosides (0.26%), cardenolides and dienolides (0.24%), flavonoids (1.28%) and steroids (1.14%). The 25 and 100 mg/kg body weight increased (P<0.05) the MF whereas the ML was decreased by all the doses of the extract. MF and ML were not altered during the second observatory period whereas the 50 mg/kg body weight increased these parameters during the third observatory period. Other sexual behaviour parameters as well as serum testosterone, FSH and LH were not significantly altered throughout the observatory periods. Overall, the results revealed that G. kola seeds did not have sex enhancing potential as claimed. Therefore, the acclaimed pro sexual effect of Garcinia kola seeds is scientifically untrue. This study has refuted the claim that one of the rationales for consuming the seeds by the aged population of Nigeria is to enhance sexual invigoration in males.

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Section: Discussionmentioning

confidence: 81%

Section: Animal Grouping Extract Administration and Monitoring Of Sementioning

confidence: 99%

<em>Garcinia Kola</em> Seeds: Is the Aqueous Extract a True Aphrodisiac in Male Wistar Rats?

Yakubu¹,

Quadri²

2012

Afr. J. Trad. Compl. Alt. Med.

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“…Among the several plants, Terminalia catappa ,[10] Allium tuberosum ,[11] Bryonia laciniosa ,[12] Elephant creeper ,[13] Montana tomentosa ,[14] Mucuna pruriens ,[15] Cucurbita pepo ,[16] Tribulus terrestris ,[17] Hypericum perforatum ,[18] Senecio cardiophyllus ,[19] Ginkgo biloba ,[20] Pausinystalia yohimbe [21] Asteracantha longifolia ,[22] Curculigo orchioides ,[12] Microdesmis keayana ,[23] etc., Most studies published on this regard have generally targeted one plant at a time even though in the traditional medicine, most of the plants are used in formulations of groups of two or four plants or even more. [10] In the present study, a polyherbal formulation (PHF) was made, on the scientific basis of the use of dried fruits of Tribulus terrestris , rhizomes of Curculigo orchioides , seeds of Allium tuberosum , seeds of Cucurbita pepo , roots of Elephant creeper , seeds of Mucuna pruriens , and seeds of Terminalia catappa , as an aphrodisiac combination and to determine the effects of the prepared formulation as suspension on sexual behavior of male rats.…”

Section: Introductionmentioning

confidence: 99%

Aphrodisiac activity of polyherbal formulation in experimental models on male rats

Sahoo¹,

Nandy²,

Senapati³

et al. 2014

Phcog Res

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Objective:To investigate the aphrodisiac potential of polyherbal formulations prepared from different parts of Tribulus terrestris, Curculigo orchioides, Allium tuberosum, Cucurbita pepo, Elephant creeper, Mucuna pruriens, and Terminalia catappa in Albino rats in specified ratio as suspension.Materials and Methods:The different concentrations of prepared polyherbal formulations i.e. 150, 300, and 600 mg/kg and sildenafil citrate as standard (5 mg/kg) and vehicle (control) were administered orally to rats (n = 6 animals per group) for 3 weeks. Mating behavior parameters in male rats was monitored in first week and third week week of treatment pairing with receptive females. After termination of drug treatment, the mating performance, hormonal analysis, sperm count, and testes-body weight ratio were also evaluated.Results:The polyherbal formulation showed a significant increase in mating behavior as well as mating performance, serum hormonal levels, sperm count, and testes-body weight ratio with dose-dependent relationship as compared to vehicle control. But the dose of 600 mg/kg of polyherbal formulation assumes closer resemblance of above parameters with the standard used.Conclusion:The results of the study strongly suggest that the polyherbal formulations have a good aphrodisiac activity on rats in the above experimental models, which may be an alternative weapon for various sexual dysfunctions in future.

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“…(nutmeg) have been suggested to be responsible for improving sexual function through changes in neurotransmitter level [9] whereas saponins in Panax ginseng act as a nitric oxide donor and induce the relaxation of smooth muscle of rabbit Corpus cavernosum through the L arginine/nitric oxide pathway [10]. In addition, alkaloids (keayanidine B and keayanine) in Microdesmis keayana roots have been reported to enhance sexual behaviour in male rats by increasing the production of nitric oxide [11]. Although, several plants and their bioactive principle(s) have been screened for sex enhancing effect, the continued search for new botanicals with aphrodisiac activity is still attractive because they are readily accessible, affordable and les toxic.…”

Section: Introductionmentioning

confidence: 99%

Effect of Aqueous Extract of Massularia acuminata Stem on Sexual Behaviour of Male Wistar Rats

Yakubu

Akanji²

2011

Evidence-Based Complementary and Alternative Medicine

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Ancient literature alluded to the use of a number of plants/preparations as sex enhancer. One of such botanicals is Massularia acuminata in which the stem has been acclaimed to be used as an aphrodisiac. Documented experiments or clinical data are, however, lacking. Therefore, this study was undertaken to evaluate the acclaimed aphrodisiac activity of M. acuminata stem. Sixty male rats were completely randomized into 4 groups (A–D) of 15 each. Rats in group A (control) were administered with 1 mL of distilled water (the vehicle) while those in groups B, C, and D were given same volume containing 250, 500, and 1000 mg/kg body weight of the extract, respectively. Sexual behaviour parameters were monitored in the male rats for day 1 (after a single dose), day 3 (after three doses, once daily), and day 5 (after five doses, once daily) by pairing with a receptive female (1 : 1). The male serum testosterone concentration was also determined. Cage side observation on the animals revealed proceptive behaviour (ear wiggling, darting, hopping, and lordosis) by the receptive female rats and precopulatory behaviour (chasing, anogenital sniffing and mounting) by the extract-treated male rats. The extract at 500, and 1000 mg/kg body weight significantly (P < .05) increased the frequencies of mount and intromission. In addition, the ejaculation latency was significantly prolonged (P < .05). The latencies of mount and intromission were reduced significantly whereas ejaculation frequency increased. The extract also reduced the postejaculatory interval of the animals. Computed percentages of index of libido, mounted, intromitted, ejaculated and copulatory efficiency were higher in the extract treated animals compared to the distilled water-administered control whereas the intercopulatory interval decreased significantly. The extract also significantly (P < .05) increased the serum testosterone content of the animals except in those administered with 250 mg/kg body weight on days 1 and 3. Data from this study identified that the aqueous extract of Massularia acuminata stem enhanced sexual behaviour in male rats. The improved sexual appetitive behaviour in male rats at the doses of 500 and 1000 mg/kg body weight of Massularia acuminata stem may be attributed, at least in part, to the alkaloids, saponins, and/or flavonoids since these phytochemicals has engorgement, androgen enhancing, and antioxidant properties.

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Effects of Microdesmis keayana roots on sexual behavior of male rats

Cited by 34 publications

References 13 publications

<em>Garcinia Kola</em> Seeds: Is the Aqueous Extract a True Aphrodisiac in Male Wistar Rats?

<em>Garcinia Kola</em> Seeds: Is the Aqueous Extract a True Aphrodisiac in Male Wistar Rats?

Aphrodisiac activity of polyherbal formulation in experimental models on male rats

Effect of Aqueous Extract of Massularia acuminata Stem on Sexual Behaviour of Male Wistar Rats

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