Effects of microcracks on the poroelastic behaviors of a single osteon

Wu, Xiaogang; Wang, Yanqin; Wu, Xiaohong; Cen, Haipeng; Guo, Yuan; Chen, Weiyi

doi:10.1007/s11433-014-5577-z

Cited by 5 publications

(6 citation statements)

References 24 publications

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“…fluid-solid interactions in cortical bone, and no body forces were taken into account [26][27][28][29] . The model used the transverse isotropic materials.…”

Section: Inner Wall Outer Wallmentioning

confidence: 99%

“…The height (h = 1 mm) is the same in all conditions, and the detailed geometry parameters will be given in concrete analysis. The properties of poroelastic materials of osteon are applied in Table 1 23,[26][27][28][29] .…”

Section: Boundary Conditions and Materials Parametersmentioning

confidence: 99%

“…In the previous study, finite element method has been proved effective in researching osteon, and the maximum compression effect occurs at about t = 0.25s 29) in a cycle. The distribution of P and V obtained by simulation was in accordance with the previous researches, and the numerical simulation data was also approach to our previous theoretical research 26) .…”

Section: Effect Of the Osteon Shape And Cross Section Curvaturementioning

confidence: 99%

“…Previous study of our group considered osteon as poroelastic materials 25) , and established mathematic and finite element model to analyse the poroelastic behaviors of osteon under different boundary conditions 26,27) , and we considered the fluid flow in osteon induced the streaming potential 28) . The poroelastic behaviors of microcracks in an osteon were evaluated 29,30) , and the direction and morphology of microcracks were fully considered 31) . However, few studies considered the alterations of osteon morphology associated with age, osteoporosis or physical activity level affect the biomechanical response of signal conduction and fluid flow.…”

Section: Introductionmentioning

confidence: 99%

“…Poroelastic finite element osteon models with different morphology were used to investigate the P and V in osteon. Based on the previous experimental study and theoretical analysis, the properties of the solid structure and interstitial fluid were assumed as transverse isotropic poroelastic material and compressible liquid, respectively 29) . In this article, we focus on analyzing the influence of the changes in morphological parameters as the shape, the cross-section, the cross-section area and the wall thickness on the P and V, and provide a further understanding of the mechanotransduction which trigger bone remodeling and bone metabolism.…”

Section: Introductionmentioning

confidence: 99%

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Finite Element Study of the Effect of Osteon Morphology Variation Related Ageing, Osteoporosis, or Physical Activity Level on Its Poroelastic Behaviors

Cen

et al. 2018

J. Hard Tissue Biology.

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The alterations of osteon morphology were caused by many factors, such as age, osteoporosis, and physical activity level. It is known that fluid flow in osteon play an important role in osteocyte mechanotransduction and hard tissue health, but less is known about these alterations of osteon morphology affect the response of fluid flow. This study aims at using poroelastic finite element analysis to investigate whether these variations of osteon morphology caused by ageing, osteoporosis, or physical activity level can affect the responses of osteon poroelastic behaviors. In this paper, the COMSOL Multiphysics software was used to establish osteon model with different morphological parameters (shape, cross-section curvature, cross-section area and wall thickness), and the effects of these parameters on the fluid pressure (P) and velocity (V) were investigated. The results showed that the osteon shape had large effects on P and V, and the peak value of P and V increased with the increase of the osteon oblateness. Then, we noticed that, the P and V had obviously positive correlation with cross-section curvature in the same region or lamellar structure in an osteon. The larger cross-sectional area caused a smaller P and V. However, the effects of osteon wall thickness showed the opposite way, the P and V amplitudes increased with the increase of the wall thickness. Significantly, our findings indicated that the wall thickness have a larger effect on P and V than that of the cross-section area. The findings of this work indicate that the alterations of osteon morphology associated with age, osteoporosis or physical activity level had significant influence on P and V in the osteon, and affect the signal transduction in the bone which have the potential research and applications value in treatment osteoporosis and other skeletal diseases.

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“…fluid-solid interactions in cortical bone, and no body forces were taken into account [26][27][28][29] . The model used the transverse isotropic materials.…”

Section: Inner Wall Outer Wallmentioning

confidence: 99%