Effects of Mianserin on Negative Symptoms in Schizophrenia

Mizuki, Yasushi; Kajimura, Naofumi; Imai, Tsuyoshi; Suetsugi, Masatomo; Kai, Shusaku; Kaneyuki, Hiroshi; Yamada, Michio

doi:10.1097/00004850-199004000-00002

Cited by 55 publications

(13 citation statements)

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“…Except for the failure with amitripty line, 12% of the n-profiles are classified as neuroleptics. Indeed, there are indications from the clinic that antide pressants may exert antipsychotic activity [36][37][38], which fits with the overall results presented in table 2. Also an anxiolytic subclass could be distinguished by this auto matic classification system: 15% of the antidepressant nprofiles were classified as anxiolytic.…”

Section: Discussionsupporting

confidence: 80%

Classification of Psychotropic Drugs Based on Pharmaco-electrocorticographic Studies in Vigilance-Controlled Rats

1993

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The effects of a number of psycho-active drugs on electrocorticographic activity (ECoG) of the rat have been studied. Frontoparietal ECoG was recorded during 6-min periods immediately before drug/vehicle administration and starting at 20 and 45 min after administration. For each 6-min recording time, a mean power spectrum was calculated and smoothed. A quotient of the power at 20 and 45 min after and before drug, respectively, was then calculated. These quotients were used as input for an analysis of variance, followed by a t test and a normalization for the degrees of freedom, resulting in so-called n-profiles. Although each drug has its own characteristic n-profile, n-profiles of drugs belonging to the same clinical class have some characteristics in common. An automated classification system of psychotropic drugs, based on parameters extracted from n-profiles by discriminant analysis, is presented. For the antidepressant drug class the success rate of correct classification of antidepressant drugs is between 53 and 88%, for a neuroleptic drug in the neuroleptic drug class the success rate is 87%, for an anxiolytic drug in the anxiolytic drug class 100% and for a psychostimulant drug in the psycho-stimulant drug class between 86 and 100%. For a reliable classification of a drug about 10 n-profiles of active doses are needed. Using n-profiles, it appeared also possible to discriminate between antidepressant, neuroleptic, anxiolytic and psychostimulant drugs based on visual judgement. Moreover, visual evaluation of the n-profiles enables 4 subclasses to be recognized within the antidepressant class, 2 subclasses within the neuroleptic and 2 subclasses within the anxiolytic class.

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Section: Discussionsupporting

confidence: 80%

Classification of Psychotropic Drugs Based on Pharmaco-electrocorticographic Studies in Vigilance-Controlled Rats

1993

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“…This observation gains further interest in view of clinical reports on the augmentation by the ␣ 2 -adrenoceptor antagonist idazoxan (Litman et al 1996), as well as the 5-HT 2A /␣ 2 -receptor antagonists mianserin (Mizuki et al 1990;Grinshpoon et al 2000) and mirtazapine (Berk et al 2001) of the clinical effect of typical antipsychotics, especially in the treatment of negative symptoms.…”

Section: Discussionmentioning

confidence: 91%

Noradrenaline Reuptake Inhibition Enhances the Antipsychotic-like Effect of Raclopride and Potentiates D2-blockage–induced Dopamine Release in the Medial Prefrontal Cortex of the Rat

Linnér

Wiker

Wadenberg

et al. 2002

Neuropsychopharmacology

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We have previously observed that addition of an (see Carlsson 1988; Farde et al. 1988). However, while being efficient in ameliorating positive symptoms, most of the typical antipsychotic drugs exhibit only a limited efficacy on, and may even exacerbate, negative symptoms in schizophrenia (Carpenter 1996). In addition, since clinically adequate dosage of (Farde et al. 1992). In contrast to the clinical profile of typical D 2 receptor antagonists, clozapine, which unfortunately may cause serious side effects such as agranulocytosis, is efficacious at considerably lower levels of D 2 receptor occupancy (Farde et al. 1992), and rarely induces EPS (see Safferman et al. 1991). The diminished induction of EPS, as well as a purportedly advantageous effect on negative and certain cognitive symptoms in schizophrenia, has led to the definition of clozapine as the prototypical atypical antipsychotic drug (Kane et al. 1988;Meltzer et al. 1989). Theories regarding the mode of action of typical versus atypical antipsychotics have emphasized the frequently potent antagonistic effect of the atypicals on serotonin (5-HT) 2A receptors and/or ␣ 1 -adrenoceptors (Meltzer et al. 1989; see Svensson et al. 1995), as well as their differential effect on regional DA neurotransmission. Thus, whereas classical antipsychotic drugs mainly enhance extracellular DA concentrations in subcortical brain regions, atypical antipsychotics preferentially increase DA, as well as noradrenaline (NA), concentrations in the medial prefrontal cortex (mPFC) of experimental animals (Imperato and Angelucci 1989; Moghaddam and Bunney 1990;Nomikos et al. 1994;Westerink et al. 2001), an effect that to a large extent seems to be mediated locally in the mPFC (Gessa et al. 2000).Among other properties, clozapine displays considerable affinity also for ␣ 2 -adrenoceptors (see Ashby and Wang 1996), and we recently reported that addition of an ␣ 2 -adrenoceptor antagonist to a selective D 2 receptor antagonist, results in a markedly enhanced DA output specifically in the mPFC, as well as an enhancement of the D 2 receptor blockage induced effect in the conditioned avoidance response (CAR) paradigm, a preclinical test with high predictive validity for clinical antipsychotic effect (Arnt 1982; see Wadenberg and Hicks 1999). Thus, when adding the ␣ 2 -adrenoceptor antagonist idazoxan to the D 2 receptor blocking regimen, an antipsychotic-like effect was obtained in spite of a considerably lower dose of the D 2 -blocker being used (Hertel et al. 1999a), yet without any concomitant increase in catalepsy, thus indicative of an atypical antipsychotic profile of the drug combination. This notion is also supported by previous clinical data demonstrating an augmenting effect of idazoxan on the therapeutic efficacy of haloperidol (Litman et al. 1996).Reboxetine is a new selective NA reuptake inhibitor (NRI), clinically used as an antidepressant, which unlike the tricyclic antidepressants shows low affinity for the muscarinic, cholinergic and adrenergic receptor families (Won...

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“…Yet only one patient in the suicide group used antidepressant at the time of suicide. Various types of antidepressants, tricyclic (20), tetracyclic (32) and selective serotonin reuptake inhibitors (33, 34), have all been used effectively with neuroleptic medication in the treatment of schizophrenic patients. The results of this study further suggest that treatment of depressive symptoms with antidepressive medication should be considered also among schizophrenic and paranoid patients.…”

Section: Discussionmentioning

confidence: 99%

Antipsychotic medication and suicide risk among schizophrenic and paranoid inpatients

Taiminen

Kujari

1994

Acta Psychiatr Scand

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A retrospective analysis of the psychotrophic medication, illness history and recent mental symptoms of 28 schizophrenic or paranoid inpatients who had committed suicide and the same number of matched control subjects was carried out. The groups were first compared separately for every variable, and 6 statistically most significant variables in the paired comparisons were then entered into a stepwise linear logistic regression model. Four statistically significant differences between the groups were found with the paired comparisons. The suicide group had more often previous suicide attempts, lower neuroleptic doses, more depressive symptoms and less positive schizophrenic symptoms compared to their controls. The results of the regression analysis suggested that the lower neuroleptic doses in the suicide group were more probably a consequence of the differences in the symptom profile than in a direct causal relationship to the suicides per se.

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Effects of Mianserin on Negative Symptoms in Schizophrenia

Cited by 55 publications

References 0 publications

Classification of Psychotropic Drugs Based on Pharmaco-electrocorticographic Studies in Vigilance-Controlled Rats

Classification of Psychotropic Drugs Based on Pharmaco-electrocorticographic Studies in Vigilance-Controlled Rats

Noradrenaline Reuptake Inhibition Enhances the Antipsychotic-like Effect of Raclopride and Potentiates D2-blockage–induced Dopamine Release in the Medial Prefrontal Cortex of the Rat

Antipsychotic medication and suicide risk among schizophrenic and paranoid inpatients

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