Effects of methylphenidate on reaction time in children with Attention Deficit Hyperactivity Disorder

Güven, Ayşegül; Altınkaynak, Miray; Dolu, Nazan; Demirci, Esra; Özmen, Sevgi; İzzetoğlu, Meltem; Pektaş, Ferhat

doi:10.29399/npa.22873

Cited by 6 publications

(5 citation statements)

References 34 publications

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“…This study was designed to investigate effectiveness of MPH medication treatment in children with ADHD by using information from changes in the concentration of oxygened haemoglobin and neuronal activity of frontal lobe during auditory oddball paradigm. We have previously shown that MPH reduced reaction times to stimuli and attenuated omission errors during the task in ADHD group [31]. The data presented here extend this finding to the prediction of robust treatment response to the MPH by multimodal EEG/ fNIRS system.…”

Section: Discussionsupporting

confidence: 80%

Effects of methylphenidate treatment in children with ADHD: a multimodal EEG/fNIRS approach

Dolu

Altınkaynak

Güven

et al. 2018

Psychiatry and Clinical Psychopharmacology

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OBJECTIVE: In this study we investigated the stimulant methylphenidate (MPH) effects in Attention deficit hyperactivity disorder (ADHD) from neuroimaging and neurophysiological perspective by simultaneous recording functional near infrared spectroscopy (fNIRS) and electroencephalography (EEG) during attention task. METHODS: Using fNIRS we obtained frontal cortex hemodynamic responses and using event related potentials (ERP) we obtained amplitude values of P3 component of 18 children with ADHD and gender matched 18 healthy controls performing an oddball task. Same recordings were repeated 3 months after extended-release MPH (OROS-MPH) administration for ADHD group. Prefrontal cortex oxygenation and P3 amplitude were compared between control and pre-MPH ADHD groups and between Pre-MPH and post-MPH ADHD groups. RESULTS: fNIRS indicated that the healthy controls exhibited higher right prefrontal activation than pre-MPH children with ADHD. Reduced P3 amplitude values were found in children with ADHD compared the control group. Reduced right prefrontal activation and P3 amplitude was normalized in ADHD group after MPH therapy. CONCLUSION: Recently multimodal neuroimaging which combine signals from different brain modalities have started to be considered as a potential to improve the accuracy of diagnosis. The current study provides MPH effect assessment in children with ADHD using multimodal EEG/fNIRS system for the first time. This study suggests combination of neuroimaging and electrophysiological parameters is a promising approach to investigate MPH effect assessment in children with ADHD.

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Section: Discussionsupporting

confidence: 80%

Effects of methylphenidate treatment in children with ADHD: a multimodal EEG/fNIRS approach

Dolu

Altınkaynak

Güven

et al. 2018

Psychiatry and Clinical Psychopharmacology

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“…Pharmacological treatment for ADHD mainly relies on psychostimulants which acts to increase synaptic levels of dopamine and noradrenaline, and have been shown to improve working memory performance as well as reduce reaction time variability [ 95 , 96 ]. ADHD has been associated with abnormal processing within attention networks and methylphenidate for example, may act to normalise this [ 97 ].…”

Section: Discussionmentioning

confidence: 99%

Working memory and reaction time variability mediate the relationship between polygenic risk and ADHD traits in a general population sample

et al. 2022

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Endophenotypes are heritable and quantifiable traits indexing genetic liability for a disorder. Here, we examined three potential endophenotypes, working memory function, response inhibition, and reaction time variability, for attention-deficit hyperactivity disorder (ADHD) measured as a dimensional latent trait in a large general population sample derived from the Adolescent Brain Cognitive DevelopmentSM Study. The genetic risk for ADHD was estimated using polygenic risk scores (PRS) whereas ADHD traits were quantified as a dimensional continuum using Bartlett factor score estimates, derived from Attention Problems items from the Child Behaviour Checklist and Effortful Control items from the Early Adolescent Temperament Questionnaire-Revised. The three candidate cognitive endophenotypes were quantified using task-based performance measures. Higher ADHD PRSs were associated with higher ADHD traits, as well as poorer working memory performance and increased reaction time variability. Lower working memory performance, poorer response inhibition, and increased reaction time variability were associated with more pronounced ADHD traits. Working memory and reaction time variability partially statistically mediated the relationship between ADHD PRS and ADHD traits, explaining 14% and 16% of the association, respectively. The mediation effect was specific to the genetic risk for ADHD and did not generalise to genetic risk for four other major psychiatric disorders. Together, these findings provide robust evidence from a large general population sample that working memory and reaction time variability can be considered endophenotypes for ADHD that mediate the relationship between ADHD PRS and ADHD traits.

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“…Studies have demonstrates that patients with ADHD improve significantly in EF when on methylphenidate (MPH), the first-choice treatment for ADHD in the developmental age [9,10]. In particular, MPH ameliorated inhibitory control [4,[11][12][13][14], visual-spatial working memory [15], sustained and selective attention [16], and reaction times (RT) [14].…”

Section: Introductionmentioning

confidence: 99%

Moderators and Other Predictors of Methylphenidate Response in Children and Adolescents with ADHD

D’Aiello

Vara

Rossi

et al. 2022

IJERPH

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Methylphenidate (MPH) is the treatment of first choice for developmental ADHD. To date, no reliable method to predict how patients will respond to MPH exists and conflicting results are reported on clinical characteristics of responders. The present study aims to give a more precise characterization of the patients who will respond best to MPH to help clinicians in defining the treatment plan. Age, neuropsychological functioning (i.e., attention and working memory), and behavioral/emotional symptoms of 48 drug-naïve children and adolescents with ADHD (42 boys and 6 girls, age-range 6–16 years, mean age 10.5 ± 2.5 years, mean IQ 101.3 ± 11.2) were studied to assess how these different characteristics affected a single-dose MPH response. Four hierarchical linear regression models were used to explore whether age, neuropsychological measures at baseline, and behavioral/emotional symptoms could predict attention and working memory measures after a single-dose MPH administration. We found that improvement in attention and working memory was predicted by age, neuropsychological measures at baseline, and severity of ADHD symptoms. No behavioral and emotional symptoms predicted single-dose MPH response with the exception of conduct symptoms.

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Effects of methylphenidate on reaction time in children with Attention Deficit Hyperactivity Disorder

Cited by 6 publications

References 34 publications

Effects of methylphenidate treatment in children with ADHD: a multimodal EEG/fNIRS approach

Effects of methylphenidate treatment in children with ADHD: a multimodal EEG/fNIRS approach

Working memory and reaction time variability mediate the relationship between polygenic risk and ADHD traits in a general population sample

Moderators and Other Predictors of Methylphenidate Response in Children and Adolescents with ADHD

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