Effects of methylphenidate on multiple components of attention in children with attention deficit hyperactivity disorder

Tucha, Oliver; Prell, Sylvia; Mecklinger, Lara; Bormann-Kischkel, Christiane; Kübber, S.; Linder, M.; Walitza, Susanne; Lange, Klaus W.

doi:10.1007/s00213-006-0318-2

Cited by 76 publications

(56 citation statements)

References 69 publications

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“…Our results are consistent with many studies on neuropsychological evaluation and ADHD, showing an improvement in WM, IC, and MF, as well as a relevant medication effect on EF performance at various levels 11,13,15,27,28 . Other studies that also analyzed attention and EF, and the effects of methylphenidate treatment in children with ADHD, did not find similar results to ours, but most of them ADHD: attention-deficit/hyperactivity disorder; M: mean; SD: standard deviation; p: t-student probability statistical significance was set at the p < 0.05 level.…”

Section: Discussionsupporting

confidence: 92%

“…Normative data on typical children have shown adequate developmental progression, highlighting the differences between the first assessment and after methylphenidate in the children with ADHD. These results suggest that these measures provide an important tool to assess children at risk for ADHD showing deficits in attention areas and EF 11,13,15,27,28,31 . We used the WISC III digit span backward and arithmetic tests to evaluate WM abilities 19 .…”

Section: Discussionmentioning

confidence: 84%

“…Adaptive inhibition requires a multitude of interrelated processes, such as the monitoring of behavior, sustained attention, conflict detection and others, before the inhibition of theplanned course of action and the behavior can be adjusted according to the moment 7,8,9,10,11 . A wide variety of neuropsychological tests indicate that ADHD children exhibit relatively weak, or sub-average, performances on various EFs 5,6,7,8,9,10,11,12,13,14,15,16,17 . Stimulants are the most commonly-used medications in the treatment of ADHD and their clinical efficacy is well established 14 .…”

mentioning

confidence: 99%

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Attention-deficit/hyperactivity disorder: the impact of methylphenidate on working memory, inhibition capacity and mental flexibility

Bolfer

Pacheco

Tsunemi

et al. 2017

Arq. Neuro-Psiquiatr.

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Objective To compare children with attention-deficit/hyperactivity disorder (ADHD), before and after the use of methylphenidate, and a control group, using tests of working memory, inhibition capacity and mental flexibility. Methods Neuropsychological tests were administrated to 53 boys, 9–12 years old: the WISC-III digit span backward, and arithmetic; Stroop Color; and Trail Making Tests. The case group included 23 boys with ADHD, who were combined type, treatment-naive, and with normal intelligence without comorbidities. The control group (n = 30) were age and gender matched. After three months on methylphenidate, the ADHD children were retested. The control group was also retested after three months. Results Before treatment, ADHD children had lower scores than the control group on the tests (p ≤ 0.001) and after methylphenidate had fewer test errors than before (p ≤ 0.001) Conclusion Methylphenidate treatment improves the working memory, inhibitory control and mental flexibility of ADHD boys.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 84%

mentioning

confidence: 99%

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Attention-deficit/hyperactivity disorder: the impact of methylphenidate on working memory, inhibition capacity and mental flexibility

Bolfer

Pacheco

Tsunemi

et al. 2017

Arq. Neuro-Psiquiatr.

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“…Bu konuda yapılan araştırmaların çoğunluğunda metilfenidat tedavisinin dikkati sürdürme/uyanıklık, davranış ketlemesi, çalışma belleği, bilgi işlemleme hızı, tepki verme zamanı ve dikkat kurulumunu değiştirme gibi işlevler üzerine olumlu etkileri olduğu bildirilmiştir. 13,[18][19][20][21][22][23][24] Ancak diğer bazı araştırmalarda, metilfenidatın bilişsel işlevler üzerinde anlamlı etki yapmadığı bulunmuştur. [24][25][26] Bir çalışmada ise metilfenidatın bilişsel işlevler üzerinde olumsuz etki yaptığı görülmüştür.…”

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“…13,[18][19][20][21][22][23][24] Ancak diğer bazı araştırmalarda, metilfenidatın bilişsel işlevler üzerinde anlamlı etki yapmadığı bulunmuştur. [24][25][26] Bir çalışmada ise metilfenidatın bilişsel işlevler üzerinde olumsuz etki yaptığı görülmüştür. 27 DEHB olgularında metilfenidatın nöropsikolojik süreçler üzerindeki etkilerini tedaviden önce ve sonra karşılaştıran araştırmalar ise az sayıdadır.…”

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Effect of Methylphenidate On Neuropsychological Functions in Children with Attention Deficit Hyperactivity Disorder

Kiriş¹,

Tahiroğlu²,

Avci³

et al. 2013

Turkiye Klinikleri J Med Sci

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Ö ÖZ ZE ET T A Am ma aç ç: : Bu çalışmanın amacı, 6 aylık uzun etkili metilfenidat (Concerta) tedavisinin, Dikkat Eksikliği Hiperaktivite Bozukluğu (DEHB) olan çocukların zekâ, seçici dikkat, odaklanmış dikkat, dikkat kurulumunu değiştirebilme, enterferansa direnç, bilgi işlemleme hızı ve multimodal kısa sü-reli bellek işlevleri üzerindeki etkilerinin araştırılması ve bu işlevlerin tedaviye yanıtının incelenmesidir. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Araştırmanın örneklemini, kliniğe başvuran ve DEHB tanısı alan, 6-12 yaş arası 20 erkek çocuk oluşturmuştur. Çalışmaya alınan tüm deneklere 6 aylık metilfenidat tedavisinden önce ve sonra Wechsler Çocuklar için Zekâ Ölçeği (WÇZÖ-R), Stroop Testi TBAG Formu (STP) ve Görsel İşitsel Sayı Dizileri-B Formu (GISD-B)'ndan oluşan nöropsikolojik test bataryası uygulanmıştır. Tedaviden önce ve sonra uygulanan nöropsikolojik test puanları arasındaki değişiklikler Wilcoxon İşaretli Sıralar testi ile analiz edilmiştir. B Bu ul lg gu ul la ar r: : Metilfenidat tedavisi WÇZÖ-R'nin özellikle performans bölümü alt test puanlarını, STP'nin ve GİSD-B'nin puanlarının büyük bölümünü anlamlı olarak etkilemiş, tedaviden sonraki performans, tedaviden öncekine göre daha yüksek olmuştur. S So on nu uç ç: : Çalışmamızın sonuçları, metilfenidat tedavisinin zekâ puanlarını ve dikkatin değişik yönlerini temsil eden puanları olumlu yönde etkilediğini göstermiştir. Metilfenidatın zekâ ve çok daha geniş bir nöropsikolojik süreçler spektrumu üzerindeki etkisinin daha büyük örneklemlerde araştırılmasının yararlı olacağı düşünülmektedir.A An na ah ht ta ar r K Ke el li im me el le er r: : Hiperaktivite ile birlikte dikkat eksikliği bozukluğu; metilfenidat; zekâ; nöropsikoloji A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : The aim of this study was to investigate the effects of six months of treatment with long acting methylphenidate (concerta) on neuropsychological functions such as intelligence, selective attention, attention set shifting, resistance to interference, speed of information processing and multimodal short term memory, and the response to treatment. M Ma a--t te er ri ia al l a an nd d M Me et th ho od ds s: : The study consisted of 20 boys aged 6 to 12 years, who were refered to our outpatient clinic and had a diagnosis of Attention Deficit Hyperactivity Disorder (ADHD). Paricipants were given the Wechsler Intelligence Scale for Childen-Revised (WISC-R) and a neuropsychological battery that consisted of Stroop Test TBAG Form (STP) and Visual auditory Digit Span-B (VADS-B) before and sixth months after methylphenidate treatment. Differences between test scores obtained from neuropsychological assesment before and after sixth months of teatment were analyzed by the Wilcoxon Signed Rank Test. R Re es su ul lt ts s: : Methylphenidate treatment had a significant effect on performance intelligence scores of WISC-R; additionally this treatment affected significantly the majority of STP and VADS-B scores. The performance on all tests increased after methylphenidate t...

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Methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD)

Storebø

Ramstad

Krogh

et al. 2015

Cochrane Database of Systematic Reviews

262

317

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Effects of methylphenidate on multiple components of attention in children with attention deficit hyperactivity disorder

Cited by 76 publications

References 69 publications

Attention-deficit/hyperactivity disorder: the impact of methylphenidate on working memory, inhibition capacity and mental flexibility

Attention-deficit/hyperactivity disorder: the impact of methylphenidate on working memory, inhibition capacity and mental flexibility

Effect of Methylphenidate On Neuropsychological Functions in Children with Attention Deficit Hyperactivity Disorder

Methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD)

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