Effects of methylphenidate on executive functioning in attention-deficit/hyperactivity disorder across the lifespan: a meta-regression analysis

Tamminga, Hyke G. H.; Reneman, Liesbeth; Huizenga, Hilde M.; Geurts, Hilde M.

doi:10.1017/s0033291716000350

Cited by 61 publications

(49 citation statements)

References 103 publications

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“…These decision rules were based on the executive function research expertise of the third author and conform to recent literature specifications about quality of outcome measures of executive function (e.g. Tamminga, Reneman, Huizenga, & Geurts, 2016). The codes are described in Appendix D.…”

Section: Data Itemsmentioning

confidence: 99%

Executive functions in trauma-exposed youth: a meta-analysis

Kelder

Akker

Geurts

et al. 2018

European Journal of Psychotraumatology

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An earlier meta-analysis and review indicated that trauma exposure may be related to lower levels of executive functioning in youth. Since different developmental trajectories were found for three core executive functions, the present study focused on working memory, inhibition, and cognitive flexibility specifically. We conducted a multi-level meta-analysis on 55 studies and 322 effect sizes published between 2001 and 2017 that were retrieved from MEDLINE, Embase, and PsycINFO. The 8070 participants in selected studies were aged 2-25 years. We investigated whether the association between constructs would be moderated by trauma-specific moderators (onset, duration, and type), and study (age, gender, ethnicity, and socio-economic status) and measurement (quality) characteristics. We found small to medium effect sizes for working memory (d = −0.49), inhibition (d = −0.46), and cognitive flexibility (d = −0.44). Moderator analyses showed that, for working memory, when studies used low-quality measurements the effect size was significantly stronger than when studies used high-quality measurements.Compared to single trauma-exposed youth, violence-exposed/abused and foster care/adopted youth showed more problems in inhibition, and foster care/adopted youth showed more problems in cognitive flexibility. Our findings imply that trauma-exposed youth have lower levels of executive functions. Clinical practice should incorporate problems in executive functioning, especially working memory, inhibition, and cognitive flexibility, in assessment and treatment guidelines.Funciones ejecutivas en jóvenes expuestos al trauma: un metanálisis Planteamiento: Un metanálisis y una revisión previos indicaron que la exposición al trauma podría estar relacionada con niveles más bajos de funcionamiento ejecutivo en los jóvenes. Objetivo: A medida que se encontraron diferentes trayectorias de desarrollo para tres funciones ejecutivas centrales, nos enfocamos específicamente en la memoria de trabajo, la inhibición y la flexibilidad cognitiva. Método: Realizamos un metanálisis multinivel con 55 estudios y 322 tamaños de efectos publicados entre 2001 y 2017, obtenidos de MEDLINE, Embase y PsycINFO. Los 8070 participantes en los estudios seleccionados tenían entre 2 y 25 años. Investigamos si la asociación entre los constructos sería moderada por los moderadores específicos del trauma (inicio, duración y tipo), y las características del estudio (edad, género, etnia, estatus socioeconómico) y características de medición (calidad). Resultados: Encontramos tamaños de efecto de pequeño a mediano para la memoria de trabajo (d = −0.49), la inhibición (d = −0.46) y la flexibilidad cognitiva (d = −0.44). Los análisis del moderador mostraron que, para la memoria de trabajo, cuando los estudios utilizaron mediciones de baja calidad, el tamaño del efecto fue significativamente más fuerte que cuando los estudios utilizaron mediciones de alta calidad. En comparación con los jóvenes expuestos a un solo trauma, los jóvenes expuestos a violencia /abus...

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Section: Data Itemsmentioning

confidence: 99%

Executive functions in trauma-exposed youth: a meta-analysis

Kelder

Akker

Geurts

et al. 2018

European Journal of Psychotraumatology

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“…Systematic reviews of the literature show that performance on task-based measures of these domains are improved by stimulants, but to a modest extent only. Tamminga and colleagues conducted a systematic review of MPH effects across the lifespan on these domains of executive functioning (Tamminga, Reneman, Huizenga, & Geurts, 2016). Across 50 studies (1,611 participants mean-aged 4.8 to 50.1), small-to-moderate effects of MPH were found.…”

Section: Effects Of Stimulants On Cognitive Processesmentioning

confidence: 99%

Why Are Long-term Benefits of Stimulant Medication So Difficult to Detect?

Molina

Swanson

2020

The ADHD Report

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“…Currently, medication is the first-line treatment recommended to improve cognitive functioning, including WM, and ADHD symptoms. Both stimulants (amphetamines and methylphenidate) and nonstimulants (atomoxetine, clonidine, and guanfacine) are used for the purpose (Fredriksen, Halmøy, Faraone, & Haavik, 2013;Strand et al, 2012;Tamminga, Reneman, Huizenga, & Geurts, 2016).…”

mentioning

confidence: 99%

Is the Cogmed program effective for youths with ADHD under pharmacological treatment ?

Dentz

Guay

Gauthier

et al. 2020

Appl Cognit Psychol

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The primary objective of this study was to examine the effects of the Cogmed training program on working memory among youths 7 to 13 years old, with attention deficit/hyperactivity disorder (ADHD) type and comorbidity controlled for. A secondary objective was to examine the generalization of effects to ADHD symptoms, nonverbal reasoning, attentional and executive functions, inhibition, reading comprehension, and mathematical reasoning. Participants were under pharmacological treatment for ADHD combined type and a comorbidity. They were randomized into an experimental group that received the Cogmed program and an active control group that received a low-intensity comparison version of the training. They were evaluated at three time points: 6 weeks prior to intervention onset (T1), immediately prior to onset (T2), and 1 week following intervention completion (T3). Results indicate no significant effect attributable to the Cogmed program. The fact that participants were on medication at the time of training and evaluation normalized their performances and limited the detection of effects. Moreover, cognitive training did not lead to a reduction in ADHD symptoms or to an improvement in the other cognitive functions measured or in academic performance. The results of this study do not demonstrate the effectiveness of the Cogmed program for youths with ADHD combined type and a comorbidity when they receive the training while under pharmacological treatment. K E Y W O R D S attention deficit/hyperactivity disorder, Cogmed, cognitive training, working memory

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Effects of methylphenidate on executive functioning in attention-deficit/hyperactivity disorder across the lifespan: a meta-regression analysis

Cited by 61 publications

References 103 publications

Executive functions in trauma-exposed youth: a meta-analysis

Executive functions in trauma-exposed youth: a meta-analysis

Why Are Long-term Benefits of Stimulant Medication So Difficult to Detect?

Is the Cogmed program effective for youths with ADHD under pharmacological treatment ?

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