Effects of methionine synthase and methionine synthase reductase polymorphisms on hypertension susceptibility

Kim, Young Ree; Kang, Sung Ha; Hong, Seong Uk

doi:10.1007/s13258-020-00917-9

Cited by 2 publications

(2 citation statements)

References 37 publications

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“…Homocysteine remethylation disorders are rare inherited disorders caused by deficient activity of the enzymes involved in the remethylation of Hcy to Met ( 89 ). Polymorphisms of the MTHFR gene are strongly associated with hypertension, and Met synthase 2756A > G and 5-methyltetrahydrofolate-homocysteine methyltransferase reductase 66A > G polymorphisms related to folate metabolism may serve as genetic markers for hypertension risk ( 90 , 91 ). Patients with MTHFR deficiency exhibit cognitive deficits and psychiatric symptoms.…”

Section: Mechanism Of the Mediation Of Cognitive Decline Induced By H...mentioning

confidence: 99%

“…We found that Met-induced global DNA hypermethylation leads to oligodendroglial and/or myelin deficits and hypermethylation of the sex-determining region of the Y-chromosome (SRY)-related HMG-box 10 (SOX10) gene, which is an important factor for terminal differentiation of oligodendrocytes and cognitive behavioral changes ( 119 ). In addition, studies have demonstrated that Met can induce hypertension in mice ( 91 , 120 , 121 ). These findings suggest that DNA methylation may enable the regulation of cognitive dysfunction in patients with hypertension, although additional studies are needed to confirm this.…”

Section: Mechanism Of the Mediation Of Cognitive Decline Induced By H...mentioning

confidence: 99%

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The new mechanism of cognitive decline induced by hypertension: High homocysteine-mediated aberrant DNA methylation

Wang

Zong²,

Chen³

2022

Front. Cardiovasc. Med.

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The prevalence and severity of hypertension-induced cognitive impairment increase with the prolonging of hypertension. The mechanisms of cognitive impairment induced by hypertension primarily include cerebral blood flow perfusion imbalance, white and gray matter injury with blood–brain barrier disruption, neuroinflammation and amyloid-beta deposition, genetic polymorphisms and variants, and instability of blood pressure. High homocysteine (HHcy) is an independent risk factor for hypertension that also increases the risk of developing early cognitive impairment. Homocysteine (Hcy) levels increase in patients with cognitive impairment induced by hypertension. This review summarizes a new mechanism whereby HHcy-mediated aberrant DNA methylation and exacerbate hypertension. It involves changes in Hcy-dependent DNA methylation products, such as methionine adenosyltransferase, DNA methyltransferases, S-adenosylmethionine, S-adenosylhomocysteine, and methylenetetrahydrofolate reductase (MTHFR). The mechanism also involves DNA methylation changes in the genes of hypertension patients, such as brain-derived neurotrophic factor, apolipoprotein E4, and estrogen receptor alpha, which contribute to learning, memory, and attention deficits. Studies have shown that methionine (Met) induces hypertension in mice. Moreover, DNA hypermethylation leads to cognitive behavioral changes alongside oligodendroglial and/or myelin deficits in Met-induced mice. Taken together, these studies demonstrate that DNA methylation regulates cognitive dysfunction in patients with hypertension. A better understanding of the function and mechanism underlying the effect of Hcy-dependent DNA methylation on hypertension-induced cognitive impairment will be valuable for early diagnosis, interventions, and prevention of further cognitive defects induced by hypertension.

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Section: Mechanism Of the Mediation Of Cognitive Decline Induced By H...mentioning

confidence: 99%

Section: Mechanism Of the Mediation Of Cognitive Decline Induced By H...mentioning

confidence: 99%

The new mechanism of cognitive decline induced by hypertension: High homocysteine-mediated aberrant DNA methylation

Wang

Zong²,

Chen³

2022

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

show abstract

Association analysis of MTHFR (rs1801133 and rs1801131) and MTRR (rs1801394) gene polymorphisms towards the development of hypertension in the Bai population from Yunnan, China

Liu

Wang

et al. 2023

Clinical and Experimental Hypertension

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Effects of methionine synthase and methionine synthase reductase polymorphisms on hypertension susceptibility

Cited by 2 publications

References 37 publications

The new mechanism of cognitive decline induced by hypertension: High homocysteine-mediated aberrant DNA methylation

The new mechanism of cognitive decline induced by hypertension: High homocysteine-mediated aberrant DNA methylation

Association analysis of MTHFR (rs1801133 and rs1801131) and MTRR (rs1801394) gene polymorphisms towards the development of hypertension in the Bai population from Yunnan, China

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