Effects of Methionine on the Immune Function in Animals

Ruan, Tao; Peng, Xi; Wu, Biao

doi:10.4236/health.2017.95061

Cited by 12 publications

(7 citation statements)

References 63 publications

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“…Methionine is a sulfuric amino acid that is important in protein synthesis. Some suggested that methionine can act as an immune regulatory factor, like IL-1 or insulin-like growth factor I. Methionine can protect cells from oxidative damage, which can also play a role in preeclampsia [ 21 , 22 , 23 , 24 ]. Methionine is also a precursor of homocysteine.…”

Section: Discussionmentioning

confidence: 99%

Maternal Amino Acid Status in Severe Preeclampsia: A Cross-Sectional Study

et al. 2022

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Introduction: Preeclampsia has been one of the leading causes of maternal death in Indonesia. It is postulated that its relationship with oxidative stress may be the underlying pathology of the disease. Nutrients and amino acids have been suggested as a scavenger for oxygen-free radicals. No previous study regarding the amino acid status in preeclampsia has been conducted in women in Indonesia. Methods: This was a cross-sectional study of a total of 64 pregnant women, 30 with normal pregnancy and 34 with severe preeclampsia. Data were obtained in Cipto Mangunkusumo National Referral Hospital in Jakarta from July to December 2020. Maternal blood samples were taken during or soon after delivery. Amino acid levels were analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Bivariate analysis was then performed. Results: We identified 19 different levels of amino acids in this study. Four amino acids that were elevated in the preeclampsia group were phenylalanine, serine, glycine, and glutamate. Serine (331.55 vs. 287.43; p = 0.03), glycine (183.3 vs. 234.35, p = 0.03), and glutamate levels (102.23 vs. 160.70, p = 0.000) were higher in preeclamptic patients. While in the essential amino acids group, phenylalanine levels (71.5 vs. 85.5, p = 0.023) were higher, and methionine levels (16.3 vs. 12.9, p = 0.022) were lower in preeclamptic patients. Conclusions: These findings suggest that severe preeclampsia had differences in concentration of some amino acids compared to normal pregnancy. Glutamate and methionine were associated with preeclampsia. Furthermore, a more detailed study regarding amino acids in the pathomechanism of preeclampsia is suggested.

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Section: Discussionmentioning

confidence: 99%

Maternal Amino Acid Status in Severe Preeclampsia: A Cross-Sectional Study

et al. 2022

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“…16 Antioksidan diketahui dapat menurunkan stress oksidatif dimana antioksidan ini memiliki kontribusi dalam menurunkan sitokin-sitokin inflamasi sehingga menyebabkan penurunan pada jumlah leukosit. 17 Asupan lemak yang berlebihan, terutama asupan lemak jenuh yang terjadi pada kelompok nonvegetarian, dapat meningkatkan simpanan lemak di dalam tubuh (trigliserida) sehingga mengakibatkan keseimbangan lemak positif dan peningkatan akumulasi jaringan adiposa. Trigliserida diketahui berhubungan dengan peningkatan jumlah sel darah putih di peredaran darah karena trigliserida memberikan suplai energi bagi pembuatan sel darah putih.…”

Section: Pembahasanunclassified

Asupan Zat Gizi Makro, Status Gizi, dan Status Imun pada Vegetarian dan Non-Vegetarian

2017

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Latar Belakang : Status imun dapat menjadi salah satu penanda kondisi sistem imun di dalam tubuh. Vegetarian umumnya memiliki indeks massa tubuh (IMT) yang lebih rendah dibandingkan dengan non-vegetarian. Hal tersebut memberikan dampak positif terhadap status imun vegetarian. Di samping itu, vegetarian juga mengalami defisiensi beberapa zat gizi yang dapat menyebabkan dampak buruk pada status imun vegetarian. Salah satu penanda status imun tubuh yaitu jumlah leukosit, dimana leukosit merupakan imunologi pertama yang muncul untuk melawan patogen.Tujuan : Membandingkan asupan zat gizi makro, status gizi, dan status imun antara vegetarian dan non-vegetarian.Metode : Sampel penelitian sebanyak 64 wanita dipilih melalui consecutive sampling yang terdiri dari 32 subjek vegetarian dan 32 subjek non-vegetarian. Berat badan dan tinggi badan dari subjek diukur untuk menentukan status gizi. Asupan zat gizi makro diukur melalui Semi Quantitative-Food Frequency Questionnaire (SQ-FFQ) dan dianalisis menggunakan program software gizi. Status imun diperoleh dari perhitungan jumlah sel darah putih (leukosit). Analisis statistik yang digunakan yaitu uji T Independen atau Mann-Whitney.Hasil : Terdapat perbedaan yang signifikan pada status gizi (p=0.019), asupan karbohidrat (p=0.002), asupan serat (p=0.001), asupan lemak jenuh (p=0.001), dan asupan lemak tidak jenuh (p=0.001) antara vegetarian dan non-vegetarian.Simpulan : Asupan karbohidrat, serat, dan lemak tidak jenuh lebih tinggi pada vegetarian sementara status gizi dan asupan lemak jenuh lebih tinggi pada non-vegetarian.

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“…Contrary to the beneficial effects of methionine restriction, other reports also showed that long‐term methionine restriction in young animals alters bone structure, stunts growth, increases homocysteine level, hepatocellular injury, oxidative stress, inflammation, and methionine deficient diet increases the risk of developing nonalcoholic steatohepatitis . Further, methionine is important to the immune system and intake of a methionine‐restricted diet over a long time makes an individual susceptible to chronic infections …”

Section: Introductionmentioning

confidence: 99%

“…[20,[38][39][40][41][42] Further, methionine is important to the immune system and intake of a methionine-restricted diet over a long time makes an individual susceptible to chronic infections. [43,44] In view of variety of literature on l-Met-S in metabolic diseases, current in vivo experiment was designed to study the effect of l-Met-S in HFD + low dose STZ-induced T2DM animals. Further, the study also aims to investigate the changes in OCM and epigenetic changes by l-Met-S in HFD + low dose STZ-induced T2DM animals.…”

Section: Introductionmentioning

confidence: 99%

Dietary Supplementation of Methyl Donor l‐Methionine Alters Epigenetic Modification in Type 2 Diabetes

Navik

Sheth

Kabeer

et al. 2019

Molecular Nutrition Food Res

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Scope The aim of the current study is to evaluate whether l‐methionine supplementation (l‐Met‐S) improves type 2 diabetes‐induced alterations in glucose and lipid metabolism by modulating one‐carbon metabolism and methylation status. Methods and Results Diabetes is induced in male Sprague–Dawley rats using high‐fat diet and low dose streptozotocin. At the end of study, various biochemical parameters, immunoblotting, qRT‐PCR and ChIP‐qPCR are performed. The first evidence that l‐Met‐S activates p‐AMPK and SIRT1, very similar to “metformin,” is provided. l‐Met‐S improves the altered key one‐carbon metabolites in diabetic rats by modulating methionine adenosyl transferase 1A and cystathione β synthase expression. qRT‐PCR shows that l‐Met‐S alleviates diabetes‐induced increase in Forkhead transcription factor 1 expression and thereby regulating genes involved in glucose (G6pc, Pdk4, Pklr) and lipid metabolism (Fasn). Interestingly, l‐Met‐S inhibits the increased expression of DNMT1 and also prevents methylation of histone H3K36me2 under diabetic condition. ChIP assay shows that persistent increase in abundance of histone H3K36me2 on the promoter region of FOXO1 in diabetic rats and it is recovered by l‐Met‐S. Conclusion The first evidence that dietary supplementation of l‐Met prevents diabetes‐induced epigenetic alterations and regulating methionine levels can be therapeutically exploited for the treatment of metabolic diseases is provided.

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Effects of Methionine on the Immune Function in Animals

Cited by 12 publications

References 63 publications

Maternal Amino Acid Status in Severe Preeclampsia: A Cross-Sectional Study

Maternal Amino Acid Status in Severe Preeclampsia: A Cross-Sectional Study

Asupan Zat Gizi Makro, Status Gizi, dan Status Imun pada Vegetarian dan Non-Vegetarian

Dietary Supplementation of Methyl Donor l‐Methionine Alters Epigenetic Modification in Type 2 Diabetes

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