Effects of methimazole pretreatment on cerulein induced acute pancreatitis in rats

Yönetçi, Nadir; Oruç, Nevin; Özütemiz, Ahmet Ömer; Kumanlıoğlu, Kamil; Yüce, Gül; Batur, Yücel

doi:10.1078/0940-2993-00248

Cited by 8 publications

(5 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our findings agree with the effect induced by thyroidectomy in rats, promoting interstitial edema and degenerative changes in the pancreatic acinar cells and decreasing the number and size of zymogen granules [ 18 ]. Nevertheless, our present findings are opposed to those obtained in rats with pancreatitis induced by cerulean, where the treatment with methimazole for 10 days has a protective action [ 35 ]. In comparison with this last study, the treatment that we used in the present study was long suggesting that chronic hypothyroidism alters the histological characteristics of exocrine pancreas.…”

Section: Discussioncontrasting

confidence: 99%

Hypothyroidism Affects Vascularization and Promotes Immune Cells Infiltration into Pancreatic Islets of Female Rabbits

Rodríguez-Castelán

Martı́nez–Gómez

Castelán

et al. 2015

International Journal of Endocrinology

View full text Add to dashboard Cite

Thyroidectomy induces pancreatic edema and immune cells infiltration similarly to that observed in pancreatitis. In spite of the controverted effects of hypothyroidism on serum glucose and insulin concentrations, the number and proliferation of Langerhans islet cells as well as the presence of extracellular matrix are affected depending on the islet size. In this study, we evaluated the effect of methimazole-induced hypothyroidism on the vascularization and immune cells infiltration into islets. A general observation of pancreas was also done. Twelve Chinchilla-breed female adult rabbits were divided into control (n = 6) and hypothyroid groups (n = 6, methimazole, 0.02% in drinking water for 30 days). After the treatment, rabbits were sacrificed and their pancreas was excised, histologically processed, and stained with Periodic Acid-Schiff (PAS) or Masson's Trichrome techniques. Islets were arbitrarily classified into large, medium, and small ones. The external and internal portions of each islet were also identified. Student-t-test and Mann-Whitney-U test or two-way ANOVAs were used to compare variables between groups. In comparison with control rabbits, hypothyroidism induced a strong infiltration of immune cells and a major presence of collagen and proteoglycans in the interlobular septa. Large islets showed a high vascularization and immune cells infiltration. The present results show that hypothyroidism induces pancreatitis and insulitis.

show abstract

Section: Discussioncontrasting

confidence: 99%

Hypothyroidism Affects Vascularization and Promotes Immune Cells Infiltration into Pancreatic Islets of Female Rabbits

Rodríguez-Castelán

Martı́nez–Gómez

Castelán

et al. 2015

International Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…The animals were randomly divided into the following three groups: control euthyroid rats (C), subclinical hypothyroid rats (SCH), and subclinical hypothyroid rats treated with L-T4 (SCH+T4) (n = 20 in each group). SCH was induced in the rats by administration of 10 mg.kg-1.d-1 [ 29 – 32 ] methimazole (MMI) once daily by gavage for 3 months. SCH+T4 rats were prepared using the same MMI administration schedule for three months and administration of 2 μg.kg-1.d-1 L-T4[ 33 – 35 ] once daily by gavage after 45 days of MMI administration.…”

Section: Methodsmentioning

confidence: 99%

Endothelial Functioning and Hemodynamic Parameters in Rats with Subclinical Hypothyroid and the Effects of Thyroxine Replacement

Gao

Liu

et al. 2015

PLoS ONE

View full text Add to dashboard Cite

ObjectiveSubclinical hypothyroidism (SCH) and its associations with atherosclerosis (AS) and cardiovascular disease remain controversial. The purpose of our study was to observe changes in endothelial functioning and hemodynamics in rats with SCH and to determine whether L-thyroxine (L-T4) administration affects these changes.MethodsIn total, sixty male Wistar rats were randomly divided into the following three groups with 20 rats each: control euthyroid rats, SCH rats and SCH rats that had been treated with thyroxine (SCH+T4). The SCH rats were induced by administration of 10 mg.kg-1.d-1 methimazole (MMI) once daily by gavage for 3 months. The SCH+T4 rats were administered the same dose of MMI for three months in addition to 2 μg.kg-1.d-1 L-T4 once daily by gavage after 45 days of MMI administration. The control rats received physiological saline via gavage.ResultsThe SCH group had significantly higher thyroid-stimulating hormone (TSH), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and endothelin (ET) levels and a lower nitric oxide (NO) level than the control and SCH+T4 groups. The tail and carotid artery blood pressures, left ventricular systolic pressure, heart rate and aorta ventralis blood flow were significantly lower in the SCH group than in the control and SCH+T4 groups. ACH treatment caused concentration-dependent relaxation, which was reduced in the SCH arteries compared with the control and SCH+T4 arteries. Histopathological examination revealed the absence of pathological changes in the SCH rat arteries.ConclusionsThese findings demonstrate that L-T4 treatment ameliorates endothelial dysfunction and hemodynamic changes in SCH rats.

show abstract

“…The results of the present study are consistent with those of a previous study that reported no association between methimazole and the development of acute pancreatitis (12). Moreover, an animal study revealed that methimazole reduced the severity of cerulean-induced acute pancreatitis in rats (13). An additional study reported that propylthiouracil attenuated pancreatic activity to reduce the mortality rate of hemorrhagic pancreatitis in dogs (14).…”

Section: Discussionmentioning

confidence: 99%

Association Between Thionamides and Acute Pancreatitis: A Case–Control Study

Guo

Chang

Chen

2020

Thyroid

View full text Add to dashboard Cite

Background: Thionamides have been extensively used to treat patients with hyperthyroidism worldwide. Recent pharmacovigilance studies have revealed a safety signal between carbimazole or methimazole and pancreatitis. The associated risk remains unclear. Methods: We identified patients with newly diagnosed acute pancreatitis from 2000 to 2013 as the case group from the Taiwan Longitudinal Health Insurance Database 2000, which contains data from 1996 to 2013. Each patient with acute pancreatitis was matched for age, sex, comorbidities, and cancer with four controls through propensity score matching. A total of 52 patients without matched controls were excluded. Sensitivity analyses including the 52 excluded patients were performed using a matching ratio of 1:2. Odds ratios (ORs) along with 95% confidence intervals (CIs) for the association were estimated using multivariate logistic regression. Results: We included 9204 and 36,816 patients in the case and control groups, respectively. The proportions of patients who had used thionamides, carbimazole, methimazole, and propylthiouracil were similar in these two groups. In addition, the adjusted OR (CI) for the association of acute pancreatitis with thionamides was 1.03 (0.86-1.24), with carbimazole it was 0.90 (0.63-1.30), with methimazole it was 1.05 (0.84-1.31), and with propylthiouracil it was 1.00 (0.74-1.34). The sensitivity analysis results were unchanged. Conclusions: We were unable to demonstrate an association between acute pancreatitis and usage of thionamides.

show abstract

Effects of methimazole pretreatment on cerulein induced acute pancreatitis in rats

Cited by 8 publications

References 27 publications

Hypothyroidism Affects Vascularization and Promotes Immune Cells Infiltration into Pancreatic Islets of Female Rabbits

Hypothyroidism Affects Vascularization and Promotes Immune Cells Infiltration into Pancreatic Islets of Female Rabbits

Endothelial Functioning and Hemodynamic Parameters in Rats with Subclinical Hypothyroid and the Effects of Thyroxine Replacement

Association Between Thionamides and Acute Pancreatitis: A Case–Control Study

Contact Info

Product

Resources

About