Effects of Methamphetamine on Single Unit Activity in Rat Medial Prefrontal Cortex In Vivo

Jang, Jinhwa; Ha, Hee-Jin; Kim, Yun Bok; Chung, Young-Ki; Jung, Min Whan

doi:10.1155/2007/29821

Cited by 6 publications

(2 citation statements)

References 47 publications

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“…Furthermore, a single MA injection evoked a robust decrease in neural firing, which is consistent with previous studies using high doses of psychostimulants in either anesthetized or awake-behaving animals (Gulley and Stanis 2010; Homayoun and Moghaddam 2006; Jang et al 2007). In the current study, no differences in baseline firing following sensitization were observed, which may be attributable to less exposure to the drug or the non-contingent route of administration.…”

Section: Discussionsupporting

confidence: 91%

Memory impairment and alterations in prefrontal cortex gamma band activity following methamphetamine sensitization

2015

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Rationale Repeated methamphetamine (MA) use leads to increases in the incentive motivational properties of the drug as well as cognitive impairments. These behavioral alterations persist for some time following abstinence, and neuroadaptations in the structure and function of the prefrontal cortex (PFC) are particularly important for their expression. However, there is a weak understanding of the changes in neural firing and oscillatory activity in the PFC evoked by repeated drug use, thus complicating the development of novel treatment strategies for addiction. Objectives The purpose of the current study was to assess changes in cognitive and brain function following MA sensitization. Methods Sensitization was induced in rats, then temporal and recognition memory were assessed after 1 or 30 days of abstinence. Electrophysiological recordings from the medial PFC were also acquired from rats whereupon simultaneous measures of oscillatory and spiking activity were examined. Results Impaired temporal memory was observed after 1 and 30 days of abstinence. However, recognition memory was only impaired after 1 day of abstinence. An injection of MA profoundly decreased neuronal firing rate and the anesthesia-induced slow oscillation (SO) in both sensitized (SENS) and control (CTRL) rats. Strong correlations were observed between the SO and gamma band power, which was altered in SENS animals. A decrease in the number of neurons phase-locked to the gamma oscillation was also observed in SENS animals. Conclusions The changes observed in PFC function may play an integral role in the expression of the altered behavioral phenotype evoked by MA sensitization.

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Section: Discussionsupporting

confidence: 91%

Memory impairment and alterations in prefrontal cortex gamma band activity following methamphetamine sensitization

2015

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“…Concerns about the neurotoxicity of methamphetamine following repeated administration are very well documented 26 43, 44 .Methamphetamine has been shown to induce toxicity in vivo and in vitro 26 affecting in particular, but not only, dopaminergic neurons 45 . Many studies have shown that the psychological and neurotoxic effects are related to dopamine release 9,46,47 although the molecular and cellular mechanisms involved in this process remain to be clarified.…”

Section: Discussionmentioning

confidence: 99%

Effect of a binge-like dosing regimen of methamphetamine on dopamine levels and tyrosine hydroxylase expressing neurons in the rat brain

Santos

Kelly

Dockery

et al. 2019

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Methamphetamine, an amphetamine derivative, is a powerful psychomotor stimulant and commonly used drug of abuse. This study examined the effect of binge-like methamphetamine (MA) dosing (4 x 4mg/kg, s.c., 2 hours apart) on regional dopamine and dopaminergic metabolite levels in rat brain at a range of early time points after final dose (2 -48 hours). Body temperature was elevated when measured 2 hours after the last dose. MA increased dopamine levels in the frontal cortex 2 and 24 hours after the last dose. The dopamine level was also increased in the amygdala at 24 hours. No change was observed in the striatum at any time point, but levels of the dopamine metabolite DOPAC were markedly reduced at 24 and 48 hours. Tyrosine hydroxylase expression is induced downstream of dopamine activity, and it is the rate limiting enzyme in dopamine synthesis. The effect of MA binge-like dosing on the volume of tyrosine hydroxylase containing cell bodies and the area fraction of tyrosine hydroxylase containing fibres was also assessed. MA increased the area fraction of tyrosine hydroxylase fibres in the frontal cortex and reduced the volume of tyrosine hydroxylase containing cell bodies 2 hours after last dose in the ventral tegmental area and the substantia nigra. An increase in cell body volume in the substantia nigra was observed 48 hours after treatment. These findings collectively highlight the importance of the dopaminergic system in methamphetamine induced effects, identify the frontal cortex, amygdala and striatum as key regions that undergo early changes in response to binge-like methamphetamine dosing and provide evidence of time-dependent effects on the cell bodies and fibres of tyrosine hydroxylase expressing neurons.

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Effect of acute and chronic restraint stress on electrical activity of prefrontal cortex neurons in the reinstatement of extinguished methamphetamine-induced conditioned place preference: An electrophysiological study

Taslimi

Komaki‬

Sarihi

et al. 2019

Brain Research Bulletin

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Effects of Methamphetamine on Single Unit Activity in Rat Medial Prefrontal Cortex In Vivo

Cited by 6 publications

References 47 publications

Memory impairment and alterations in prefrontal cortex gamma band activity following methamphetamine sensitization

Memory impairment and alterations in prefrontal cortex gamma band activity following methamphetamine sensitization

Effect of a binge-like dosing regimen of methamphetamine on dopamine levels and tyrosine hydroxylase expressing neurons in the rat brain

Effect of acute and chronic restraint stress on electrical activity of prefrontal cortex neurons in the reinstatement of extinguished methamphetamine-induced conditioned place preference: An electrophysiological study

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