Effects of Methacholine on Insulin Secretion in Man

Kajinuma, Hiroshi; Kaneto, Akio; Kuzuya, Tsunehiko; Nakao, Kazuwa

doi:10.1210/jcem-28-9-1384

Cited by 21 publications

(13 citation statements)

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“…Received for publication 16 August 1972 and in revised form 9 October 1972. affect insulin output suggests that if they were to be released, they would be expected to alter insulin secretion directly and influence the islet cell response to other regulators of insulin secretion. Norepinephrine, the sympathetic neurotransmitter, has been found to inhibit insulin release by stimulation of the alpha adrenergic receptor (4,5).…”

Section: Introductionmentioning

confidence: 99%

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Neural Regulation of Insulin Secretion in the Dog

Porte¹,

Girardier²,

Seydoux³

et al. 1973

J. Clin. Invest.

162

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A B S T R A C T The effects of stimulation of the mixed autonomic nerve to the dog pancreas has been studied under conditions in which both pancreaticoduodenal vein blood flow and insulin concentration were determined. Stimulation resulted in increased insulin output, which was blocked by prior administration of atropine. Blood flow was reduced by stimulation in proportion to the rate of stimulation. At 40 stimuli/s a maximum effect was found at 1 min with a gradual return toward base line despite continued application of the stimulus. Atropinization had no effect on blood flow changes. Insulin responses to 0.1 g/kg glucose were reduced on the average 40% by simultaneous stimulation of the pancreatic nerve at 40 cycles/s in atropinized animals. These studies establish this preparation as a reproducible model for the direct examination of autonomic influences on endocrine pancreatic function. From them it is concluded that the nerve supply to the endocrine pancreas of the dog is sufficient to inhibit insulin secretion by activation of the sympathetic nerves and to stimulate insulin secretion by activation of the parasympathetic nerves.

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Section: Introductionmentioning

confidence: 99%

“…Acetylcholine or its analogues have been found to increase insulin release both in vitro and in vivo (4,9). Stimulation of the parasympathetic vagus nerve has been shown to release insulin (10,11).…”

Section: Introductionmentioning

confidence: 99%

Neural Regulation of Insulin Secretion in the Dog

Porte¹,

Girardier²,

Seydoux³

et al. 1973

J. Clin. Invest.

162

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“…Evidence for a central noradrenolytic action of phentolamine has been provided by studies showing that its injection into the AH or third ventricle significantly attenuates the hypothermia elicited by NE infused 15 min later into the same site in conscious cats [ [36] and in vivo studies in dogs [19. 32] and man [31]. Thus, autonomic nervous system regulation of IRI has received considerable experimental support, and per haps may be best interpreted in terms of G ellhorn' s postulation that hypo thalamic tuning, sympathetic vs. parasympathetic, is an essential determi nant of vegetative function [23,24], The physiological significance of vagal innervation to the endocrine pancreas, however, remains to be clarified.…”

Section: Discussionmentioning

confidence: 99%

Central α-Adrenergic Regulation of Growth Hormone and Insulin

et al. 1972

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Serum growth hormone (GH) fell and serum insulin (IRI) rose within 30 min following infusion of phentolamine, an α-adrenergic blocking agent, into the anterior hypothalamus or third ventricle of conscious, fasted baboons. GH and IRI were unchanged following intravenous infusion systemically of phentolamine at doses 2 to 4 times greater than given centrally, indicating that the reciprocal changes in GH and IRI did not result from direct action of phentolamine on the adenohypophysis and pancreatic islets. Rather, these data suggest that the phentolamine blocked hypothalamic adrenergic mechanisms participating in the normal regulation of GH and IRI. Plasma glucose and 17-OHCS rose and plasma glycerol fell in association with changes in GH and IRI, but blood pressure, heart rate and internal temperature were not altered.

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“…Data have also accumulated to support a role for the parasympathetic autonomic nervous system in modifying insulin release. Acetylcholine stimulates insulin release in vitro (11,15), as defined in a static system, and cholinergic agents (20,21) including nicotinic acid (22) stimulate insulin release in vivo. Further, both vagal stimulation (23,24) and pancreatic nerve stimulation (25) result in an increase in insulin release.…”

Section: Introductionmentioning

confidence: 99%

“…Further, both vagal stimulation (23,24) and pancreatic nerve stimulation (25) result in an increase in insulin release. Finally, atropinie has been showIn to inhlibit conditioned insulin release (26), insulin release secondary to vagal stimulation (20,21), and to inhibit insulin release in response to oral glucose but not that induced by intravenous glucose (27).…”

Section: Introductionmentioning

confidence: 99%