Effects of metformin on insulin resistance, androgen concentration, ovulation and pregnancy rates in women with polycystic ovary syndrome following laparoscopic ovarian drilling 
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Abstract

Metformin improves insulin resistance, reduces androgen levels and significantly increases the ovulation and pregnancy rates in infertile women, following LOD.

Effect of preconceptional metformin on abortion risk in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials

“…A total of 28 RCTs potentially resulted for inclusion in the meta-analysis (22,, but of these 11 studies were excluded. In particular, the abortion rate was not evaluated in two studies (35,50), data on the abortion rate were not available from papers and could not be obtained from the investigators after E-mail contact for five studies (30,37,44,53,54), and it was not possible to contact the corresponding investigators for four studies (31,33,47,49). Thus, a total of 17 RCTs (22, 32, 34, 36, 38-43, 45, 46, 48, 51, 52, 55, 56) were included in the final analysis.…”

Inositol versus Metformin administration in polycystic ovary syndrome patients

“…Serum progesterone (P) level more than 5 ng/ml was considered to indicate confirmation of ovulation. The study showed that Metformin improved insulin resistance, reduced androgen levels, and significantly increased the ovulation and pregnancy rates in infertile women following LOD [25]. In another study, 20 women with PCOS were administered either 2 g of myo-inositol plus 200 mcg folic acid or a placebo of 200 mcg folic acid daily.…”

“…Kocak and Ustun [25] carried out a randomized study in 2006 to evaluate the effects of Metformin on insulin resistance, androgen concentration, ovulation rates, and pregnancy rates in infertile women with PCOS. They studied 42 infertile women with PCOS.…”

Insulin-sensitizing agents and reproductive function in polycystic ovary syndrome patients

“…In addition, the study [39] showed significant cost effectiveness favouring metformin treatment as metformin was about 20-fold cheaper than LOD. Moreover, no significant benefit in terms of pregnancy or live-birth rates was observed when metformin followed LOD in comparison with LOD alone [40].…”