“…One week later, other dystrophic hallmarks (central nucleation, decreased muscle strength) are established and fully developed pathology can be observed at 6-8 weeks of age, including increased production of several extracellular matrix components, muscle atrophy and decreased body weights in both genders (Nevo et al, 2010;McKee et al, 2017;Fontes-Oliveira et al, 2018;Moreira Soares Oliveira et al, 2018; Tables 2, 3). Reduced muscle strength and mobility between 4-10 weeks of age has been clearly documented in several studies (Dadush et al, 2010;McKee et al, 2017;Fontes-Oliveira et al, 2018;Gawlik et al, 2018;Moreira Soares Oliveira et al, 2018;Pasteuning-Vuhman et al, 2018). The follow-up of the dy 2J /dy 2J mouse condition up to 34 weeks of age did not reveal significant muscle pathology progression compared to 6week-old mice (Pasteuning-Vuhman et al, 2018), except for the additional body weight loss between week 6-10 (Fontes- Oliveira et al, 2018).…”