Effects of Metal Fragments on Nerve Healing in Extremity Injuries Using a Rat Peroneal Nerve Model

Surgeon Perspectives on Alternative Nerve Repair Techniques

“…Seery et al reported that the presence of metal around nerve repairs hampered neural regeneration in a rodent model. Their investigation, however, was specifically aimed at evaluating the effects of shrapnel, and they implanted fragments from an artillery casing [25]. Payne et al, by contrast, supported the use of medical grade titanium stapleassisted neurrohaphy [22].…”

Effect of Combined Nicotine and Shrapnel Exposure on Pain Measures and Gait After Nerve Injury

“…Thus, studies have shown that tobacco possess many negative effects on the healing of many types of tissues and this is of major concern because of the increasing use of tobacco products among the American population. [8][9][10][11] In addition, in a recent study performed by Seery et al, 2 they were able to test and demonstrate a functional decrease in nerve function related to retained metal fragments. Seery et al 2 found that the recovery of function after peroneal nerve transection was decreased when insoluble metal fragments were placed in and around the injury site.…”

“…1 In the past, it has been a common practice not to remove the metal fragments that remained near the nerve injury. However, in a recent study conducted by Seery et al, 2 the presence of retained insoluble metal fragments like those found in artillery was found to decrease nerve healing. Furthermore, studies have shown that metals that are located away from the site of the repair nerve injury still have a negative impact on the functional gait (unpublished data).…”

Anatomic variations of brachial and lumbosacral plexus models in different rat strains

“…Selection of the specific nerve for research protocol includes consideration of parameters, such as nerve diameter, length, nerve type, and also the design of experimental nerve study. Depending on the study objectives, different nerves of the rat forelimb and hindlimb were adapted as the experimental models . Although in the preclinical studies on peripheral nerve repair, the rat sciatic nerve is the most commonly used experimental model …”