Effects of metabolic control on vitamin E nutritional status in children with type 1 diabetes mellitus

Campoy, Cristina; Baena, Rosa Ma; Blanca, E.; López-Sabater, M. Carmen; Fernández-García, José Manuel; Miranda, Marı́a Isabel; Molina-Font, J. A.

doi:10.1054/clnu.2002.0596

Cited by 14 publications

(9 citation statements)

References 22 publications

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“…This result is in disagreement with most of the data of the literature (5,7,10,11), but in agreement with a few studies (12,13). This result is in disagreement with most of the data of the literature (5,7,10,11), but in agreement with a few studies (12,13).…”

Section: Exercise Increases Adiponectin Levels and Insulin Sensitivitcontrasting

confidence: 56%

“…Some patients were weaned off medical therapy and continued to be euglycemic; however, none of them became hyperglycemic or diabetic. Diabetes in these transgenic mice was thought to be due to sustained unregulated Ca influx and premature ␤-cell apoptosis (burn-out phenomenon) (13,14). Intravenous glucose tolerance was performed in all patients and showed a blunted insulin response in two with no overt hyperglycemia.…”

Section: Alfonso Arranz MD Victor Andia Md Antonio Ló Pez-guzmá N Mdmentioning

confidence: 99%

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Simultaneous Bilateral Facial Palsy in a Diabetic Patient

et al. 2004

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Section: Exercise Increases Adiponectin Levels and Insulin Sensitivitcontrasting

confidence: 56%

Section: Alfonso Arranz MD Victor Andia Md Antonio Ló Pez-guzmá N Mdmentioning

confidence: 99%

Simultaneous Bilateral Facial Palsy in a Diabetic Patient

et al. 2004

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“…This is corroborated by the findings that various antioxidants in plasma and cells have not been shown to be decreased consistently in the diabetic state 19‐22. For example, there are as many studies that have reported a decrease in plasma vitamin C or E levels as studies that have found no change in diabetic states 19‐24. However, it is also likely that antioxidant levels in the plasma are not reflective of the levels in the tissues.…”

Section: Induction Of Oxidants By Diabetic or Insulin‐resistant Statesmentioning

confidence: 72%

Oxidative Stress and Antioxidant Treatment in Diabetes

Scott

King

2004

Annals of the New York Academy of Sciences

180

114

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The many studies on oxidative stress, antioxidant treatment, and diabetic complications have shown that oxidative stress is increased and may accelerate the development of complications through the metabolism of excessive glucose and free fatty acids in diabetic and insulin-resistant states. However, the contribution of oxidative stress to diabetic complications may be tissue-specific, especially for microvascular disease that occurs only in diabetic patients but not in individuals with insulin resistance without diabetes, even though both groups suffer from oxidative stress. Although antioxidant treatments can show benefits in animal models of diabetes, negative evidence from large clinical trials suggests that new and more powerful antioxidants need to be studied to demonstrate whether antioxidants can be effective in treating complications. Furthermore, it appears that oxidative stress is only one factor contributing to diabetic complications; thus, antioxidant treatment would most likely be more effective if it were coupled with other treatments for diabetic complications.

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“…Furthermore, using this approach has yielded inconsistent and occasionally conflicting results when comparing diabetic patients with controls (48,443,458;reviewed in Ref. 33).…”

Section: Dietary (Exogenous) Small Molecule Antioxidantsmentioning

confidence: 99%

Positive and Negative Regulation of Insulin Signaling by Reactive Oxygen and Nitrogen Species

Bashan¹,

Kovsan²,

Kachko³

et al. 2009

Physiological Reviews

475

373

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Regulated production of reactive oxygen species (ROS)/reactive nitrogen species (RNS) adequately balanced by antioxidant systems is a prerequisite for the participation of these active substances in physiological processes, including insulin action. Yet, increasing evidence implicates ROS and RNS as negative regulators of insulin signaling, rendering them putative mediators in the development of insulin resistance, a common endocrine abnormality that accompanies obesity and is a risk factor of type 2 diabetes. This review deals with this dual, seemingly contradictory, function of ROS and RNS in regulating insulin action: the major processes for ROS and RNS generation and detoxification are presented, and a critical review of the evidence that they participate in the positive and negative regulation of insulin action is provided. The cellular and molecular mechanisms by which ROS and RNS are thought to participate in normal insulin action and in the induction of insulin resistance are then described. Finally, we explore the potential usefulness and the challenges in modulating the oxidant-antioxidant balance as a potentially promising, but currently disappointing, means of improving insulin action in insulin resistance-associated conditions, leading causes of human morbidity and mortality of our era.

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Effects of metabolic control on vitamin E nutritional status in children with type 1 diabetes mellitus

Cited by 14 publications

References 22 publications

Simultaneous Bilateral Facial Palsy in a Diabetic Patient

Simultaneous Bilateral Facial Palsy in a Diabetic Patient

Oxidative Stress and Antioxidant Treatment in Diabetes

Positive and Negative Regulation of Insulin Signaling by Reactive Oxygen and Nitrogen Species

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