Effects of Mesenteric Ischemia and Reperfusion on Small Bowel Electrical Activity

Hegde, Sanjay S.; Seidel, Scott A.; Ladipo, J K; Bradshaw, Leonard A.; Halter, Susan A.; Richards, William O.

doi:10.1006/jsre.1997.5232

Cited by 26 publications

(32 citation statements)

References 10 publications

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“…Owing to difficulty in noninvasively recording intestinal slow waves, little is known on the alterations and regulatory mechanisms of intestinal slow waves. Some studies have reported the impairment of intestinal slow waves with intestinal distention and inhibition of intestinal slow wave frequency and amplitude with mesenteric ischemia (19)(20)(21)(22). NO has been reported to exert a tonic inhibitory influence on intestinal myoelectric activity by reducing the frequency of Migrating Motor Complex (MMC) pacesetter and by suppressing the postprandial spike activity in dogs (23,24).…”

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confidence: 99%

Inhibitory Effects of Sildenafil on Small Intestinal Motility and Myoelectrical Activity in Dogs

Chen

2006

Dig Dis Sci

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Previous studies have shown that sildenafil inhibits the esophageal motility in both humans and animals. The aim of this study was to investigate the effects of sildenafil on intestinal myoelectrical activity and motility. The study was composed of 2 experiments and performed in 7 healthy female dogs with a duodenal cannula 20 cm beyond pylorus (19-26 kg). The first experiment was designed to study the effects of sildenafil on intestinal myoelectrical activity and it included 2 sessions each consisting of 30-minute baseline, 15-minute posttreatment (placebo or 100 mg sildenafil) and 90 minutes after a liquid meal. Intestinal myoelectrical activity was recorded during the entire experiment period. The second experiment was aimed to investigate the effect of sildenafil on intestinal motility and was performed immediately after a solid meal. Intestinal motility was measured by a manometric catheter inserted into the small intestine via the duodenum cannula for 30 minutes at baseline and 60 minutes after sildenafil. Sildenafil significantly reduced the amplitude but had no effect on the frequency and regularity of the intestinal myoelectrical activity. Sildenafil significantly inhibited postprandial intestinal contractions. Although the frequency of the contractions was not altered, the mean area under the curve was significantly reduced during the first 30 minutes (P < .03) and second 30 minutes after sildenafil (P < .03); the power of intestinal contractile activities was also significantly reduced during the first 30 minutes (P < .0004) and second 30 minutes after sildenafil (P < .0003) in comparison with baseline. In conclusion, sildenafil inhibits the amplitude of both intestinal contractile activity and intestinal slow waves.

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confidence: 99%

Inhibitory Effects of Sildenafil on Small Intestinal Motility and Myoelectrical Activity in Dogs

Chen

2006

Dig Dis Sci

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“…Additionally, it is important to note that the duration of ischemia in our model is 30 min, during which there were no obvious signs of histological destruction (Fig. ), which is in contrast to what has been described previously . Previously reported models of small intestinal I/R indicated that there is a requirement for at least 60 min of ischemia in order to observe obvious histological changes after reperfusion .…”

Section: Discussionmentioning

confidence: 55%

Monitoring dynamic alterations in calcium homeostasis by T₁‐mapping manganese‐enhanced MRI (MEMRI) in the early stage of small intestinal ischemia–reperfusion injury

et al. 2015

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Manganese-enhanced MRI studies have proven to be useful in monitoring physiological activities associated with calcium ions (Ca(2+)) due to the paramagnetic property of the manganese ion (Mn(2+)), which makes it an excellent probe of Ca(2+) . In this study, we developed a method in which a Mn(2+)-enhanced T1 -map MRI could enable the monitoring of Ca(2+) influx during the early stages of intestinal ischemia-reperfusion (I/R) injury. The Mn(2+) infusion protocol was optimized by obtaining dose-dependent and time-course wash-out curves using a Mn(2+)-enhanced T1-map MRI of rabbit abdomens following an intravenous infusion of 50 mmol/l MnCl2 (5-10 nmol/g body weight (BW)). In the rabbit model of intestinal I/R injury, T1 values were derived from the T1 maps in the intestinal wall region and revealed a relationship between the dose of the infused MnCl2 and the intestinal wall relaxation time. Significant Mn(2+) clearance was also observed over time in control animals after the infusion of Mn(2+) at a dose of 10 nmol/g BW. This technique was also shown to be sensitive enough to monitor variations in calcium ion homeostasis in vivo after small intestinal I/R injury. The T1 values of the intestinal I/R group were significantly lower (P < 0.05) than that of the control group at 5, 10, and 15 min after Mn(2+) infusion. Our data suggest that MnCl2 has the potential to be an MRI contrast agent that can be effectively used to monitor changes in intracellular Ca(2+) homeostasis during the early stages of intestinal I/R injury.

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“…Like the heart, diseases of the small bowel cause changes in the electrical activity that may indicate underlying pathology. Previous studies suggest that there are changes in the intestinal SWF and uncoupling that occur shortly after the onset of ischemia [3], [4], [5]. Thus, intestinal SWF content provides valuable information regarding the health of the small bowel.…”

Section: Introductionmentioning

confidence: 99%

Detection of Small Bowel Slow-Wave Frequencies From Noninvasive Biomagnetic Measurements

Erickson

Obioha

Goodale

et al. 2009

IEEE Trans. Biomed. Eng.

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We report a novel method for identifying the small intestine electrical activity slow wave frequencies from noninvasive biomagnetic measurements. Superconducting QUantum Interference Device (SQUID) magnetometer measurements are pre-processed to remove baseline drift and high frequency noise. Subsequently, the underlying source signals are separated using the well-known SOBI algorithm. A simple classification scheme identifies and assigns some of the SOBI components to a section of small bowel. Slow wave frequencies were clearly identified in 10 out of 12 test subjects to within 0.09-0.25 cycles per minute. The method is sensitive at the 40.3-55.9% level, while false positive rates were 0-8.6%. This technique could potentially be used to help diagnose gastrointestinal ailments and obviate some exploratory surgeries.

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Effects of Mesenteric Ischemia and Reperfusion on Small Bowel Electrical Activity

Cited by 26 publications

References 10 publications

Inhibitory Effects of Sildenafil on Small Intestinal Motility and Myoelectrical Activity in Dogs

Inhibitory Effects of Sildenafil on Small Intestinal Motility and Myoelectrical Activity in Dogs

Monitoring dynamic alterations in calcium homeostasis by T₁‐mapping manganese‐enhanced MRI (MEMRI) in the early stage of small intestinal ischemia–reperfusion injury

Detection of Small Bowel Slow-Wave Frequencies From Noninvasive Biomagnetic Measurements

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Effects of Mesenteric Ischemia and Reperfusion on Small Bowel Electrical Activity

Cited by 26 publications

References 10 publications

Inhibitory Effects of Sildenafil on Small Intestinal Motility and Myoelectrical Activity in Dogs

Inhibitory Effects of Sildenafil on Small Intestinal Motility and Myoelectrical Activity in Dogs

Monitoring dynamic alterations in calcium homeostasis by T1‐mapping manganese‐enhanced MRI (MEMRI) in the early stage of small intestinal ischemia–reperfusion injury

Detection of Small Bowel Slow-Wave Frequencies From Noninvasive Biomagnetic Measurements

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Monitoring dynamic alterations in calcium homeostasis by T₁‐mapping manganese‐enhanced MRI (MEMRI) in the early stage of small intestinal ischemia–reperfusion injury