Effects of mesencephalic reticular formation lesions on optokinetic nystagmus

Komatsuzaki, Atsushi; Alpert, Jack N.; Harris, Henry E.; Cohen, Bernard

doi:10.1016/0014-4886(72)90047-7

Cited by 33 publications

(8 citation statements)

References 8 publications

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“…The present findings indicate that this structure can generate nystagmus of the same type as the nucleus of the optic tract. Komatsuzaki et al (1972) found that lesions in the mesencephalic reticular formation strongly interfered with optokinetic reactions in the monkey. They suppose that this area is especially involved in generating the slow phase to the ipsilateral side; this suggestion is in agreement with the present results.…”

Section: The Optokinetic Pathwaymentioning

confidence: 98%

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Oculomotor areas in the rabbit's midbrain and pretectum

Collewijn

1975

J. Neurobiol.

190

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The role of some meso- and diencephalic structures in eye movements was investigated by ablation and stimulation experiments. Optokinetic nystagmus was abolished by small lesions in the lateral pretectum, but not by complete removal of the superior colliculi. Stimulation of the superior colliculus and other visual centers was effective in eliciting nystagmus (slow phase ipsilateral), but the most efficient trigger zones are found in the lateral pretectum and the midbrain tegmentum. Only from these areas could nystagmus still be elicited after degeneration of the primary optic fibers. The lateral pretectal trigger zone is probably identical with the nucleus of the optic tract. It is postulated that this nucleus is an essential station for horizontal optokinetic reactions. Saccades were obtained by stimulation of the mesencephalic central grey, but not for any visual centers such as the superior colliculus.

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Section: The Optokinetic Pathwaymentioning

confidence: 98%

“…The midbrain tegmentum does not, receive primary optic fibers but has been often considered a premotor area for eye movements (Komatsuzaki, Alpert, Harris and Cohen, 1972).…”

Section: Coding Of the Effectsmentioning

confidence: 99%

Oculomotor areas in the rabbit's midbrain and pretectum

Collewijn

1975

J. Neurobiol.

190

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“…Yet its connections have received only limited study in primates. The first evidence that the midbrain reticular formation (MRF) was involved in oculomotor control came from lesion studies (Bender and Shanzer 1964; Komatsuzaki et al 1972). These indicated effects on horizontal gaze and the optokinetic reflex for eye movements into the field across from the lesion.…”

Section: Introductionmentioning

confidence: 99%

A central mesencephalic reticular formation projection to the supraoculomotor area in macaque monkeys

2015

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The central mesencephalic reticular formation is physiologically implicated in oculomotor function and anatomically interwoven with many parts of the oculomotor system’s premotor circuitry. This study in Macaca fascicularis monkeys investigates the pattern of central mesencephalic reticular formation projections to the area in and around the extraocular motor nuclei, with special emphasis on the supraoculomotor area. It also examines the location of the cells responsible for this projection. Injections of biotinylated dextran amine were stereotaxically placed within the central mesencephalic reticular formation to anterogradely label axons and terminals. These revealed bilateral terminal fields in the supraoculomotor area. In addition, dense terminations were found in both the preganglionic Edinger-Westphal nuclei. The dense terminations just dorsal to the oculomotor nucleus overlap with the location of the C-group medial rectus motoneurons projecting to multiply innervated muscle fibers suggesting they may be targeted. Minor terminal fields were observed bilaterally within the borders of the oculomotor and abducens nuclei. Injections including the supraoculomotor area and oculomotor nucleus retrogradely labeled a tight band of neurons crossing the central third of the central mesencephalic reticular formation at all rostrocaudal levels, indicating a subregion of the nucleus provides this projection. Thus, these experiments reveal that a subregion of the central mesencephalic reticular formation may directly project to motoneurons in the oculomotor and abducens nuclei, as well as to preganglionic neurons controlling the tone of intraocular muscles. This pattern of projections suggests an as yet undetermined role in regulating the near triad.

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“…The main sequence is a feature of both human and nonhuman primate saccades (Fuchs et al 1985). It is shared by all types of rapid eye movements, including vestibular and optokinetic fast phases (Komatsuzaki et al 1972;Ron et al 1972). The stereotyped relationship between movement dynamics and kinematics reflects the fact that the velocity trajectories of rapid eye movements, unlike the movements of other body parts, are not under conscious control.…”

Section: Introductionmentioning

confidence: 99%

Eye-Hand Coordination: Saccades Are Faster When Accompanied by a Coordinated Arm Movement

Snyder

Calton

Dickinson

et al. 2002

Journal of Neurophysiology

112

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When primates reach for an object, they very often direct an eye movement toward the object as well. This pattern of directing both eye and limb movements to the same object appears to be fundamental to eye-hand coordination. We investigated interactions between saccades and reaching movements in a rhesus monkey model system. The amplitude and peak velocity of isolated eye movements are positively correlated with one another. This relationship is called the main sequence. We now report that the main sequence relationship for saccades is changed during coordinated eye and arm movements. In particular, peak eye velocity is approximately 4% faster for the same size saccade when the saccade is accompanied by a coordinated arm movement. Saccade duration is reduced by an equivalent amount. The main sequence relationship is unperturbed when the arm moves simultaneously but in the opposite direction as the eyes, suggesting that eye and arm movements must be tightly coordinated to produce the effect. Candidate areas mediating this interaction include the posterior parietal cortex and the superior colliculus.

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Effects of mesencephalic reticular formation lesions on optokinetic nystagmus

Cited by 33 publications

References 8 publications

Oculomotor areas in the rabbit's midbrain and pretectum

Oculomotor areas in the rabbit's midbrain and pretectum

A central mesencephalic reticular formation projection to the supraoculomotor area in macaque monkeys

Eye-Hand Coordination: Saccades Are Faster When Accompanied by a Coordinated Arm Movement

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