Effects of mercuric chloride on the activities of brain enzymes in a fresh water teleost,Ophiocephalus (Channa) punctatus

Sastry, K.V.; Sharma, Kamana

doi:10.1007/bf01055294

Cited by 30 publications

(13 citation statements)

References 15 publications

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“…Reduction in ALP activity in the brain might be a consequence of changes in the permeability of plasma membrane, in addition to an alteration in balance between the synthesis and degradation of enzymes (Rao, 1997). In agreement with our data, Sastry and Sharma (1979) have reported decreased ALP activity in teleost brain due to mercury exposure.…”

Section: Discussionsupporting

confidence: 95%

Melatonin protection on mercury-exerted brain toxicity in the rat

Rao

Purohit

Patel

2010

Drug and Chemical Toxicology

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The effect of melatonin on the neurotoxicity induced by mercuric chloride was studied. Adult rats were fed orally with two different doses of mercuric chloride (2 mg; 4 mg/kg body weight) to evaluate brain toxicity with respect to cerebral hemisphere, cerebellum, and medulla oblongata regions for 60 days with or without supplementation with melatonin (5 mg/kg body weight) intraperitoneally. The results suggest that the graded doses of mercury elicit the depletion of enzymatic activities, such as adenosine triphosphatase, succinate dehydrogenase, phosphorylase, alkaline phosphatase, acid phosphatase, altered glycogen, total protein, and lipid peroxidation levels in the cerebral hemisphere, cerebellum, and medulla oblongata of the brain, thereby affecting their respective functions. Blood glucose and mercury levels increased, followed by a reduction in body and organ weights. All these effects seemed to be severe in the cerebral hemisphere of the brain. Further affected indices were, to some extent, maintained in the brain of animals cotreated with melatonin, showing its protective role against mercury-exerted neurotoxicity.

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Section: Discussionsupporting

confidence: 95%

Melatonin protection on mercury-exerted brain toxicity in the rat

Rao

Purohit

Patel

2010

Drug and Chemical Toxicology

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“…However, during distribution of small amounts of mercury, effects that are less pronounced than those associated with acute and massive chronic poisoning could be exerted on tissues in the body. Hg2+, in micromolar concentrations, has been shown in vitro to exert actions on isolated heart (21) and smooth-muscle contractions (22), neuromuscular (23)(24)(25)(26)(27)(28), synaptic (29,30), and sensory (31) transmission, Ca2+ release from sarcoplasmic reticulum (32), respiration and metabolism in brain tissue (33), activity of brain enzymes (34), and other activities vital for the function of excitable tissues (35,36). However, it is not qpite clear whether or how lower concentrations, <1 pM, of mercuric salts influence the physiologic functions of excitable tissues.…”

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confidence: 99%

Effects of mercuric ions on isolated guinea-pig ileum

Moberg

1986

Acta Odontologica Scandinavica

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The possible physiological significance of low concentrations of Hg2+ in the guinea-pig ileum has been investigated. Responses to nerve stimulation by single electrical shocks, acetylcholine (ACh), and histamine (Hi) and the response to ACh of a depolarized preparation were examined. A stimulant effect of Hg2+, in the concentration range of 10 nM-1 microM, dominated in intestine accommodated in biological saline solution. This excitatory effect was probably mainly due to stimulation of a depolarization-coupled initiation of the contraction. The inhibitory effect of Hg2+, 10 nM-1 microM, observed in depolarized muscle was presumably due to a decreased Ca2+ availability for the contractile process. In the higher concentration range, 1-100 microM, a probably direct action on the contractile elements causing irreversible deterioration of the preparation seems to be present.

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“…Investigators have used histochemistry techniques to evaluate the stress effect produced by heavy metal on animals (Jackim, Hamlin, and Sonis 1970;Shastri and Sharma 1980; Toxicological & Environmental Chemistry 117 Thurberg, Calabrese, and Tuckrer 1977). In this study histologically cerebral ganglion showed several neurons of variable size (giant, large, medium, and small) with clear-cut differentiation.…”

Section: Discussionmentioning

confidence: 97%