Effects of menopause and tibolone on different cardiovascular biomarkers in healthy women

Vassalle, Cristina; Cicinelli, Ettore; Lello, Stefano; Mercuri, Antonella; Battaglia, Debora; Maffei, Silvia

doi:10.3109/09513590.2010.488770

Cited by 20 publications

(9 citation statements)

References 46 publications

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“…Tibolone and its 3‐hydroxy metabolites have also been shown to exert direct vascular anti‐inflammatory actions and to inhibit leukocyte adhesion molecule expression in human endothelial cells (Simoncini and Genazzani, ). Tibolone had a beneficial effect on inflammation in postmenopausal women, reducing the level of tumour necrosis factor‐α but not interleukin (IL)‐6 (Vassalle et al., ). Oral administration of tibolone to OVX rats has been demonstrated to increase the β‐endorphin levels in the pituitary and plasma, similar to the administration of oestradiol benzoate (Genazzani et al., ).…”

Section: Discussionmentioning

confidence: 99%

Effects of tibolone on osteoarthritis in ovariectomized rats: Association with nociceptive pain behaviour

Yang

et al. 2013

European Journal of Pain

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Section: Discussionmentioning

confidence: 99%

Effects of tibolone on osteoarthritis in ovariectomized rats: Association with nociceptive pain behaviour

Yang

et al. 2013

European Journal of Pain

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“…Tibolone (TB), a synthetic steroid that has been used as an elective treatment for the relief of menopausal symptoms, and its various metabolites have estrogenic as well as progestogen/androgenic effects [11]. TB treatment in rats decreased OS markers [12], body weight, and total cholesterol levels [13], whereas in studies conducted with postmenopausal women, TB improved blood pressure, glycemia [14], insulin levels, HDL cholesterol, and triglycerides [15]. However, the acute effects of HT with TB on metabolic parameters and OS markers associated with the first stages of ED are still unknown.…”

Section: Introductionmentioning

confidence: 99%

Acute Administration of Tibolone Prevents Oxidative Stress in Ovariectomized Rats Fed High-Fat-and-Fructose Diet

Cruz

Pérez

Barrera

et al. 2018

Exp Clin Endocrinol Diabetes

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In addition to oxidative stress due to the increase of free radicals, estrogen deficiency is associated with changes in enzymatic activity, glutathione redox ratio (GSH/GSSG), and the content of oxidative markers such as malondialdehyde. Tibolone, a synthetic steroid, has been used as an elective treatment for the relief of menopausal symptoms. However, the acute effects of hormonal therapy with tibolone on metabolic parameters and oxidative stress markers associated with the first stages of estrogen deficiency are still unknown. The study aimed to evaluate if the acute administration of tibolone reduces oxidative stress in ovariectomized rats fed high-fat-and-fructose diet. Rats were fed a standard diet or a diet consisting of 10% lard-supplemented chow and 20% high-fructose syrup in the drinking water plus tibolone or vehicle for seven days. Weight, cholesterol, triglycerides, and glucose levels, as well as antioxidant enzymes and oxidative stress markers were quantified in the serum of each experimental group. It was observed that seven days of diet and tibolone treatment in the ovariectomized group reduced weight, triglycerides, cholesterol, glucose levels and advanced glycation end products but did not change GSH/GSSG ratio nor the enzymatic activity of superoxide dismutase. Also, both glutathione peroxidase and glutathione reductase activity decreased, as well as malondialdehyde levels. These results suggest that the acute treatment with tibolone prevented the changes in the metabolic parameters analyzed as well as the increase in the levels of malondialdehyde and AGEs induced by ovariectomy and high-fat diet.

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“…With respect to the lipid profile, tibolone exerted the undesirable effect of lowering HDL cholesterol levels, as described before [14,49]. The mechanisms by which tibolone exerts this effect are uncertain, but they could involve androgenic actions of the tibolone metabolites or a more rapid HDL clearance [50,51].…”

Section: Discussionmentioning

confidence: 96%

Tibolone Reverses NAFLD in Ovariectomised Rats by Reducing Adiposity and Insulin Resistance

Campos-Shimada¹,

Gilglioni²,

Hermoso³

et al. 2019

JPP

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This study aimed to investigate the effects of tibolone, a synthetic steroid, on several metabolic dysfunctions induced by oestrogen deficiency, in rats. Ovariectomised (OVX) rats were used as animal model of postmenopausal metabolic syndrome. The OVX rats were treated with daily doses of tibolone (0.16 mg/kg) and the results were compared with control (sham-operated) and OVX untreated rats. Tibolone reduced the adiposity and the visceral adipocyte size in OVX rats. The insulin sensitivity was also improved, and a decrease in the activity of the adipose tissue hormone-sensitive lipase enzyme was recorded. The lower lipolysis by visceral adipocytes, associated with the recovery of peroxisomal β-oxidation by tibolone may have contributed to the reversion of NAFLD in treated OVX rats. The reduction of liver lipid contents resulted in a general improvement in the liver redox state. In addition, tibolone reduced the mitochondrial ROS generation and restored the activity of glucose-6-phosphate dehydrogenase. Tibolone also exerted antioxidant effects on inguinal adipose tissue. Tibolone exerted several beneficial effects on cellular and metabolic dysfunctions induced by ovariectomy in rats. One important mode of action of tibolone was the reduction of the visceral adipocyte size, corroborating the relationship between this one and the development and progression of several comorbidities associated with metabolic syndrome.

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Effects of menopause and tibolone on different cardiovascular biomarkers in healthy women

Cited by 20 publications

References 46 publications

Effects of tibolone on osteoarthritis in ovariectomized rats: Association with nociceptive pain behaviour

Effects of tibolone on osteoarthritis in ovariectomized rats: Association with nociceptive pain behaviour

Acute Administration of Tibolone Prevents Oxidative Stress in Ovariectomized Rats Fed High-Fat-and-Fructose Diet

Tibolone Reverses NAFLD in Ovariectomised Rats by Reducing Adiposity and Insulin Resistance

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