Effects of menopause and postmenopausal tibolone treatment on plasma TNFα, IL-4, IL-10, IL-12 cytokine pattern and some bone turnover markers

Vural, Pervin; Canbaz, Mukaddes; Akgül, Cemil

doi:10.1016/j.phrs.2006.01.005

Cited by 38 publications

(32 citation statements)

References 43 publications

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“…This is in part true for young women during the reproductive years when hormonal and metabolic factors are causing an atheroprotective physiologic environment. 9,10 However, elderly women are deprived from this beneficial effect of reproductive hormones 11 and are at least as likely as men to develop atherosclerotic disease. 3,4 There are also other possible factors that do not allow prompt medical treatment of vascular disease in women.…”

Section: Discussionmentioning

confidence: 99%

Lessons learned from the analysis of gender effect on risk factors and procedural outcomes of lower extremity arterial disease

Vouyouka

Egorova

Salloum

et al. 2010

Journal of Vascular Surgery

121

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Introduction: Despite overall improvement, there is still a gender-related disparity in the outcomes of lower extremities peripheral arterial disease (PAD). We analyzed sex-related variability among factors that are known to influence outcomes. Methods: Data on PAD inpatient hospitalizations from New York, New Jersey, and Florida state hospital discharge databases (1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007) were analyzed using univariate and multivariate logistic regression analyses. Results: Of the 372,692 surgical hospitalizations identified, 162,730 (43.66%) involved women. Men and women undergoing vascular procedures differed in that more men smoked (18% vs 14%; P < .0001), and more men had coronary artery disease (40% vs 33%; P < .0001). Women were more likely to be obese (11.86% vs 4.89%; P <.0001), black (18.81% vs 12.66%; P < .0001), older, and have critical limb ischemia (CLI) (39.41% vs 37.67%; P < .0001). They had higher mortality (5.26% vs 4.21%; P < .0001) and complication rates, especially bleeding (10.62 % vs 8.19%; P < .0001) and infection (3.23% vs 2.88%; P < .0001). Mortality rates after endovascular procedures were lower and showed marginal difference between genders (2.87% vs 2.11%; P < .0001). The difference was more pronounced after open revascularizations (5.05% for women vs 4.00% for men; P <.0001) and amputations (9.82% for women vs 8.82% for men; P < .0001). 1.15, 1.21, and 1.32, respectively). Female gender negatively influenced the mortality of patients with cerebrovascular and coronary disease and those of black race even after adjusting for relevant clinical and demographic risk factors. Gender effect on mortality dissipated in octogenarians and patients with claudication. Conclusion: Female gender continues to be an important risk factor that negatively influences the outcomes of vascular interventions; however, these effects vary between different high-risk groups and procedures. Gender effect on mortality dissipates in elderly patients. Prompt recognition of the associations between gender and various risk factors of cardiovascular disease and aggressive modification of these risk factors in female patients may improve gender-related disparity in the outcomes of vascular disease. ( J Vasc Surg 2010;52:1196-1203.) Bleeding differences between men and women were greatest when both open and endovascular procedures were done during the same hospitalizations and lowest after major amputations. Similar to bleeding, transgender differences in postoperative infections were more pronounced after combination of open and endovascular procedures. Using a multivariable model, female gender remained a predictor of perioperative mortality, infection, and bleeding after vascular intervention (odds ratios

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Section: Discussionmentioning

confidence: 99%

Lessons learned from the analysis of gender effect on risk factors and procedural outcomes of lower extremity arterial disease

Vouyouka

Egorova

Salloum

et al. 2010

Journal of Vascular Surgery

121

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“…Additional studies have reported that post-menopausal women (between the age of 52 and 70) taking HT for at least 12 months prior to the study have increased numbers of B cells and better T-cell proliferative responses than post-menopausal women who are not undergoing any HT (Porter et al 2001). Moreover, post-menopausal women (>48 years and time since menopause >1.6 years) have higher plasma levels of the inflammatory cytokines TNFα and IFNγ compared to pre-menopausal subjects (Deguchi et al 2001;Vural et al 2006a;Vural et al 2006b), and HT results in a decrease in serum level of TNFα (Vural et al 2006a), IFNγ (Deguchi et al 2001), and IL-6 (Saucedo et al 2002). Similarly, ovariectomy increases IL-6 plasma levels in adult female rhesus macaque, and this change is reversed upon estradiol administration (Keller et al 2001).…”

Section: Introductionmentioning

confidence: 99%

Accelerated immune senescence and reduced response to vaccination in ovariectomized female rhesus macaques

Engelmann

Barron

Urbanski

et al. 2010

AGE

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Aging is associated with a general dysregulation in immune function, commonly referred to as "immune senescence". Several studies have shown that female sex steroids can modulate the immune response. However, the impact of menopauseassociated loss of estrogen and progestins on immune senescence remains poorly understood. To help answer this question, we examined the effect of ovariectomy on T-cell homeostasis and function in adult and aged female rhesus macaques. Our data show that in adult female rhesus macaques, ovariectomy increased the frequency of naïve CD4 T cells. In contrast, ovariectomized (ovx) aged female rhesus macaques had increased frequency of terminally differentiated CD4 effector memory T cells and inflammatory cytokine-secreting memory T cells. Moreover, ovariectomy reduced the immune response (T-cell cytokine and IgG production) following vaccination with modified vaccinia ankara in both adult and aged female rhesus macaques compared to ovary-intact age-matched controls. Interestingly, hormone therapy (estradiol alone or in conjunction with AGE (2011) 33:275-289

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“…In contrast, transdermal administration of estrogen does not change IL-2 levels, probably because plasma levels achieved via this delivery route are too low to modulate T cell functions (Saucedo, Rico et al 2002). IL-4 plasma levels were reported to increase after menopause and HT reverses this increase (Vural, Canbaz et al 2006;Yasui, Maegawa et al 2007). In PHA stimulated whole blood, IL-4 production increases in mid menopause and then becomes significantly lower in late menopause (Deguchi, Kamada et al 2001).…”

Section: Inflammation and Menopausementioning

confidence: 99%

“…Some studies reported an increase in TNF and IL-1 after menopause that is reversed by HRT Vural, Canbaz et al 2006), while other studies reported no changes (Yasui, Maegawa et al 2007). The impact of menopause on IL-10 and IL-12 is equally controversial with some studies reporting an increase (Deguchi, Kamada et al 2001;Vural, Canbaz et al 2006), while others report no change (Yasui, Maegawa et al 2007) or a decrease in these cytokines . HRT and transdermal estrogen do not seem to have an impact on IL-10 levels (Saucedo, Rico et al 2002;Vural, Canbaz et al 2006).…”

Section: Inflammation and Menopausementioning

confidence: 99%

“…The impact of menopause on IL-10 and IL-12 is equally controversial with some studies reporting an increase (Deguchi, Kamada et al 2001;Vural, Canbaz et al 2006), while others report no change (Yasui, Maegawa et al 2007) or a decrease in these cytokines . HRT and transdermal estrogen do not seem to have an impact on IL-10 levels (Saucedo, Rico et al 2002;Vural, Canbaz et al 2006). A negative correlation of IL-8 with estrogen level was reported in both humans and mice (Yasui, Maegawa et al 2007;Abu-Taha, Rius et al 2009).…”

Section: Inflammation and Menopausementioning

confidence: 99%

See 1 more Smart Citation

Modulation of Immune Senescence by Menopause and Hormone Therapy

Engelmann¹,

Asquith²,

Messaoudi³

2012

Sex Steroids

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Effects of menopause and postmenopausal tibolone treatment on plasma TNFα, IL-4, IL-10, IL-12 cytokine pattern and some bone turnover markers

Cited by 38 publications

References 43 publications

Lessons learned from the analysis of gender effect on risk factors and procedural outcomes of lower extremity arterial disease

Lessons learned from the analysis of gender effect on risk factors and procedural outcomes of lower extremity arterial disease

Accelerated immune senescence and reduced response to vaccination in ovariectomized female rhesus macaques

Modulation of Immune Senescence by Menopause and Hormone Therapy

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