Effects of memantine on the passive avoidance test in young rats

Gorbachenko, V. A.; Lukyanetz, E. A.

doi:10.15407/fz66.05.003

Cited by 5 publications

(4 citation statements)

References 16 publications

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“…The results of the present study indicate an increase in post-shock latency in the treatment group of baicalein with memantine at a 20 + 10 mg/kg dose. The improvement in post-shock latency was also observed in the memantine treatment group by Gorbachenko and Lukyanetz (2020) and the baicalein-treated group by Wong et al (2014). Those findings are in line with our study results.…”

Section: Discussionsupporting

confidence: 92%

Effects of baicalein with memantine on aluminium chloride-induced neurotoxicity in Wistar rats

Jadhav

Kulkarni²

2023

Front. Pharmacol.

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Alzheimer’s disease is a progressive neurodegenerative condition. It is one of the most common 28 forms of dementia accounting for 60–80% of people suffering from dementia. There are very few medications that are approved for the treatment of Alzheimer’s disease. Baicalein, belonging to the flavone subclass of flavonoids, has been reported to have a neuroprotective effect by reducing oxidative stress and neuroinflammation, inhibiting the AChE enzyme, and reducing amyloid protein aggregation and toxicity. Memantine is one of the most important drugs used for treating Alzheimer’s disease. The purpose of this work was to study the effect of baicalein with memantine on aluminum chloride-induced neurotoxicity in Wistar rats. Aluminum chloride (100 mg/kg p.o.) was administered for 42 days in male Wistar rats to induce neurotoxicity. Baicalein alone (10 mg/kg) and a combination of baicalein (5 mg/kg and 10 mg/kg) with memantine (20 mg/kg) were administered for 42 days. Treatment of baicalein with memantine showed significant improvement in behavioral parameters. The combination reduced oxidative stress and the formation of β-Amyloid plaques and increased brain-derived neurotrophic factor (BDNF) expression. Based on findings, it can be concluded that treatment with baicalein and memantine may slow the progression of neurodegeneration in rats.

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Section: Discussionsupporting

confidence: 92%

Effects of baicalein with memantine on aluminium chloride-induced neurotoxicity in Wistar rats

Jadhav

Kulkarni²

2023

Front. Pharmacol.

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“…Memantine has also shown procognitive effects in preclinical AD models. In rat experiments, memantine prevented short-term memory deficits caused by Aβ1-40, improved long-term memory consolidation impaired by soluble beta-amyloid, enhanced spatial memory in animals injected with Aβ1-42 oligomers, and improved performance in other behavioral memory tests (Kruchenko et al, 2014;Tyshchenko and Lukyanetz, 2017;Gorbachenko and Lukyanetz, 2020). The effect of memantine on the viability status of hippocampal neurons treated by Aβ1-42.…”

Section: Discussionmentioning

confidence: 95%

Memantine protects the cultured rat hippocampal neurons treated by NMDA and amyloid β1–42

Rozumna,

Hanzha,

Lukyanetz

2023

Front. Neurosci.

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Alzheimer’s disease (AD) is a devastating neurodegenerative condition with no effective treatments. Recent research highlights the role of NMDA receptors in AD development, as excessive activation of these receptors triggers excitotoxicity. Memantine, an NMDA receptor antagonist, shows promise in curbing excitotoxicity. What sets our study apart is our novel exploration of memantine’s potential to protect hippocampal neurons from neurotoxicity induced by NMDA and amyloid β1–42, a hallmark of AD. To achieve this, we conducted a series of experiments using rat hippocampal cell cultures. We employed Hoechst and propidium iodide double staining to assess neuronal viability. Analyzing the viability of neurons in normal conditions compared to their status after 24 h of exposure to the respective agents revealed compelling results. The incubation of hippocampal neurons with NMDA or amyloid β1–42 led to a more than twofold increase in the number of apoptotic and necrotic neurons. However, when memantine was co-administered with NMDA or amyloid β1–42, we witnessed a notable augmentation in the number of viable cells. This unique approach not only suggests that memantine may act as a neuroprotective agent but also emphasizes the relevance of hippocampal neuron cultures as valuable models for investigating excitotoxicity and potential AD treatments.

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“…In this study, memantine in week 8 significantly reduced the frequency of avoidance symptom compared to baseline but had no significant effect on other symptoms (Intrusion and Hyperarousal). A preferential reduction in the excitatory impulse to inhibitory neurons in the cortical circuits and subsequent changes in the balance between excitation and inhibition are two mechanisms suggested to explain the therapeutic benefits of memantine ( 31 ).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Add-on Memantine in New Onset Combat-Related Posttraumatic Stress Disorder Core Symptoms: A Pilot Study

Rajabi,

Fozveh,

Maracy

2023

IJPS

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Objective: Studies using standard neuropsychological instrumentation have shown memory deficits in posttraumatic stress disorder (PTSD) patients. We examined the efficacy and safety of memantine in new cases of combat-related PTSD in the military by conducting a 16-week prospective double-blind randomized controlled trial. Method: Twenty-six new combat-related PTSD cases were recruited from among the military personnel based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). Patients were assigned to memantine and Placebo groups. They were monitored at baseline, week eight, and week 16. Memantine was added to each patient's current medication with an initial dosage of 5 mg/day, raised by 5 mg/day every week until it reached the maintenance level of 20 mg/day. The concurrent drugs were essentially kept unchanged during the trial. The primary outcome was PTSD severity as assessed by the Clinician-administered PTSD Scale (CAPS). The CAPS is a valid and reliable tool for the diagnosis of PTSD and measurement of its severity according to the DSM–4. Results: CAPS mean score in baseline (P = 0.811) and weeks eight (P = 0.389) and 16 (P = 0.066) did not show any significant differences between the two groups. The mean CAPS score in the memantine group significantly (P = 0.006) decreased (Mean differences = -8.79) compared to the placebo group, showing that intervention with memantine was effective. The mean total CAPS in weeks eight (Mean differences = -14.21) and 16 (Mean differences = -27) were less than the baseline, which was significantly meaningful (P < 0.001). Conclusion: Findings of this study suggest that add-on memantine can be effective in veteran patients with PTSD. So our data provide useful insight into the management of new cases of combat-related PTSD.

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Effects of memantine on the passive avoidance test in young rats

Cited by 5 publications

References 16 publications

Effects of baicalein with memantine on aluminium chloride-induced neurotoxicity in Wistar rats

Effects of baicalein with memantine on aluminium chloride-induced neurotoxicity in Wistar rats

Memantine protects the cultured rat hippocampal neurons treated by NMDA and amyloid β1–42

The Effect of Add-on Memantine in New Onset Combat-Related Posttraumatic Stress Disorder Core Symptoms: A Pilot Study

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