Effects of Melatonin Supplementation on Hormonal, Inflammatory, Genetic, and Oxidative Stress Parameters in Women With Polycystic Ovary Syndrome

Jamilian, Mehri; Foroozanfard, Fatemeh; Mirhosseini, Naghmeh; Kavossian, Elham; Aghadavod, Esmat; Bahmani, Fereshteh; Ostadmohammadi, Vahidreza; Kia, Mersedeh; Eftekhar, Tahereh; Ayati, Elnaz; Mahdavinia, Mostafa; Asemi, Zatollah

doi:10.3389/fendo.2019.00273

Cited by 53 publications

(29 citation statements)

References 52 publications

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“…One of the main findings of the present study was the beneficial effects of melatonin (alone or in combination) on testosterone. In line with our finding, Jamilian and colleagues indicated that melatonin administration for three months to PCOS women significantly reduced total testosterone [ 44 ]. In another study, long-term (6 months) melatonin administration to women with PCOS had beneficial effects on menstrual irregularities and biochemical hyperandrogenism [ 45 ].…”

Section: Discussionsupporting

confidence: 92%

Metabolic and hormonal effects of melatonin and/or magnesium supplementation in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial

et al. 2021

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Background Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among women of reproductive age. This study was designed to investigate the effects of melatonin and/or magnesium supplementation on metabolic profile and levels of sex hormones in PCOS women. Methods In an 8-week randomized double-blind placebo-controlled trial, 84 subjects with PCOS aged 18–40 years were randomly assigned based on the random block procedure to take magnesium, melatonin, magnesium plus melatonin, and placebo. Fasting blood samples were obtained at the beginning and end of the study. Results After intervention, the mean Pittsburg Sleep Quality Index score decreased significantly in both co-supplementation and melatonin groups (P < 0.001). Magnesium supplementation in combination with melatonin resulted in a significant greater decrease in testosterone concentrations compared with the placebo (P < 0.05). Co-supplementation of magnesium-melatonin had significantly reduced serum insulin levels (geometric means difference: − 1.11 (mIU/mL) (percent change: − 15.99)), homeostasis model of assessment-insulin resistance (HOMA-IR) (− 0.28 (− 18.66)), serum cholesterol (mean difference: − 16.08 (mg/dl) [95% CI − 24.24, − 7.92]), low-density lipoprotein cholesterol (LDL-C) − 18.96 (mg/dl) [− 28.73, − 9.20]) and testosterone levels (− 0.09 (ng/ml) (− 25.00)), as compared to the baseline values (P < 0.05). An increase in serum high-density lipoprotein cholesterol (HDL-C) levels was also observed following the administration of the melatonin alone (2.76 (mg/dl) [0.57, 4.95]) or in combination with magnesium (2.19 (mg/dl) [0.61, 3.77]) (P < 0.05). Conclusions Co-supplementation with magnesium and melatonin had beneficial effects on sleep quality and total testosterone. Additionally, melatonin supplementation alone was found to be associated with a significant reduction in PSQI score. Moreover, combined melatonin and magnesium supplementation was more effective in improving serum levels of cholesterol, LDL-C, HDL-C and insulin, and HOMA-IR. Trial registration: Iranian Registry of Clinical Trial. http://www.irct.ir: IRCT20191130045556N1, January 2020.

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Section: Discussionsupporting

confidence: 92%

Metabolic and hormonal effects of melatonin and/or magnesium supplementation in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial

et al. 2021

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“…A similar reduction of PCOS-related hirsutism and androgen levels after 12 weeks of melatonin supplementation was also found in a recent investigation by Jamilian et al (117). Thus, the therapeutic use of melatonin in women with PCOSrelated conditions shows promise, and should be explored further.…”

Section: Summary and Future Perspectivessupporting

confidence: 80%

Melatonin and Female Reproduction: An Expanding Universe

Olcese

2020

Front. Endocrinol.

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For more than a half century the hormone melatonin has been associated with vertebrate reproduction, particularly in the context of seasonal breeding. This association is due in large measure to the fact that melatonin secretion from the pineal gland into the peripheral circulation is a nocturnal event whose duration is reflective of night length, which of course becomes progressively longer during winter months and correspondingly shorter during the summer months. The nocturnal plasma melatonin signal is conserved in essentially all vertebrates and is accessed not just for reproductive rhythms, but for seasonal cycles of metabolic activities, immune functions, and behavioral expression. A vast literature on melatonin and vertebrate biology has accrued over the past 60 years since melatonin's discovery, including the broad topic of animal reproduction, which is far beyond the scope of this human-focused review. Although modern humans in the industrialized world appear in general to have little remaining reproductive seasonality, the relationships between melatonin and human reproduction continue to attract widespread scientific attention. The purpose of this chapter is to draw attention to some newer developments in the field, especially those with relevance to human fertility and reproductive medicine. As the vast majority of studies have focused on the female reproductive system, a discussion of the potential impact of melatonin on human male fertility will be left for others.

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“…In high concentrations (micromolar), melatonin is a free radical scavenger. At low levels (picomolar), melatonin acts by binding to membrane receptors [33][34][35].…”

Section: Discussionmentioning

confidence: 99%

Effects of Selenium and Melatonin on Ocular Ischemic Syndrome

2019

CMR

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Purpose. To determine the effects of selenium, melatonin, and selenium + melatonin administered for one month on anterior chamber (AC) malondialdehyde (MDA) and AC glutathione (GSH) levels in patients with ocular ischemic syndrome. Materials and Methods. irty-five patients were included in the study. Study groups were formed as follows: (1) control group, (2) ischemia group, (3) selenium + ischemia group, (4) melatonin + ischemia group, and (5) selenium + melatonin + ischemia group. AC samples were obtained. MDA and GSH levels in AC samples were evaluated. Results. MDA levels were significantly increased in ischemia groups. Selenium and melatonin supplementation resulted in reduction of MDA levels and significant increase in GSH values. Discussion. Increased lipid peroxidation associated with ischemia of the anterior segment has been prevented by selenium and melatonin supplementation. is trial is registered with ClinicalTrials.gov NCT04005222.

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Effects of Melatonin Supplementation on Hormonal, Inflammatory, Genetic, and Oxidative Stress Parameters in Women With Polycystic Ovary Syndrome

Cited by 53 publications

References 52 publications

Metabolic and hormonal effects of melatonin and/or magnesium supplementation in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial

Metabolic and hormonal effects of melatonin and/or magnesium supplementation in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial

Melatonin and Female Reproduction: An Expanding Universe

Effects of Selenium and Melatonin on Ocular Ischemic Syndrome

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