Effects of melatonin supplementation on BDNF concentrations and depression: A systematic review and meta-analysis of randomized controlled trials

Mashhadi, Nafiseh Shokri; Darand, Mina; Rouhani, Mohammad Hossein; Yahay, Maryam; Feltham, Bradley A.; Saraf‐Bank, Sahar

doi:10.1016/j.bbr.2022.114083

Cited by 10 publications

(4 citation statements)

References 67 publications

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“…On the other hand, a meta-analysis by Fan and co-workers indicates that melatonin has a moderate effect on depression [57]. Similarly, other studies and controlled trials have found that melatonin soothes depressive symptoms [58,59]. Patients taking agents for sleeping disorders were not recruited in the present trial; therefore, the fatigue improvement in patients from the intervention group was probably attributable to melatonin supplementation.…”

Section: Discussionmentioning

confidence: 74%

The Effect of Melatonin Supplementation on Cancer-Related Fatigue during Chemotherapy Treatment of Breast Cancer Patients: A Double-Blind, Randomized Controlled Study

Nimee,

Gioxari,

Papandreou

et al. 2024

Cancers

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Cancer-related fatigue (CRF) is a common distressing complaint of breast cancer (BC) patients treated with chemotherapy. Nutritional quality plays a pivotal role in CRF, while increased interest towards new pharmacological agents has been observed. Melatonin, an endogenous hormone that regulates the human sleep–wake cycle, could alleviate CRF. In the present randomized, placebo-controlled 3-month trial, we investigated the effects of melatonin intake (i.e., 1 mg/day) vs. placebo in BC patients on CRF. In both arms, the Mediterranean diet (MD) was implemented. Medical history, anthropometry and blood withdrawal were performed. CRF was evaluated by the Functional Assessment of Chronic Illness Therapy—Fatigue questionnaire and MD adherence by the MedDietScore. In total, 49 BC women (median age 52 years) were recruited, namely N = 23 in the intervention arm and N = 26 in the placebo arm. At baseline, CRF was positively associated with body mass index (BMI), even when adjusted for age, waist circumference and blood indices related to disease prognosis (beta = −0.882, p = 0.003). At 3 months, both groups showed a BMI decrease (p < 0.05), but only the intervention group improved CRF compared to baseline (p = 0.003). No differences in CRF were observed between the groups. In conclusion, melatonin oral supplementation could ameliorate CRF in BC patients.

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Section: Discussionmentioning

confidence: 74%

The Effect of Melatonin Supplementation on Cancer-Related Fatigue during Chemotherapy Treatment of Breast Cancer Patients: A Double-Blind, Randomized Controlled Study

Nimee,

Gioxari,

Papandreou

et al. 2024

Cancers

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“… 74 Nevertheless, a recent meta-analysis did not confirm the same effect in humans. 75 Future research on the subjects of interplay between the circadian rhythm, melatonin, and BDNF would be desirable. Organic and functional aspects of changes in the circadian rhythm occurring in the course of various CRSDs might be further studied in the context of BDNF and other neurotrophins.…”

Section: Neurobiology Of Bdnfmentioning

confidence: 99%

Investigating the Role of BDNF in Insomnia: Current Insights

Ditmer,

Gabryelska,

Turkiewicz

et al. 2023

NSS

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Insomnia is a common disorder defined as frequent and persistent difficulty initiating, maintaining, or going back to sleep. A hallmark symptom of this condition is a sense of nonrestorative sleep. It is frequently associated with other psychiatric disorders, such as depression, as well as somatic ones, including immunomediated diseases. BDNF is a neurotrophin primarily responsible for synaptic plasticity and proper functioning of neurons. Due to its role in the central nervous system, it might be connected to insomnia of multiple levels, from predisposing traits (neuroticism, genetic/epigenetic factors, etc.) through its influence on different modes of neurotransmission (histaminergic and GABAergic in particular), maintenance of circadian rhythm, and sleep architecture, and changes occurring in the course of mood disturbances, substance abuse, or dementia. Extensive and interdisciplinary evaluation of the role of BDNF could aid in charting new areas for research and further elucidate the molecular background of sleep disorder. In this review, we summarize knowledge on the role of BDNF in insomnia with a focus on currently relevant studies and discuss their implications for future projects.

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“…Given that melatonin has been described as being able, alone [ 275 , 276 ] or in combination with exercise [ 277 ], to induce an increase in BDNF brain levels in animals, one can suppose that melatonin acts in a stimulating way on neurogenesis partially via its ability to raise BDNF levels and thus promote NSCs proliferation. However, the lack of evidence for a stimulatory effect of melatonin on serum BDNF levels in humans invites caution regarding this hypothesis [ 278 ].…”

Section: Role Of Melatonin In Regulating the Cell Cycle During Neurog...mentioning

confidence: 99%

Melatonin as a Harmonizing Factor of Circadian Rhythms, Neuronal Cell Cycle and Neurogenesis: Additional Arguments for Its Therapeutic Use in Alzheimer’s Disease

Shukla

Vincent

2023

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The synthesis and release of melatonin in the brain harmonize various physiological functions. The apparent decline in melatonin levels with advanced aging is an aperture to the neurodegenerative processes. It has been indicated that down regulation of melatonin leads to alterations of circadian rhythm components, which further causes a desynchronization of several genes and results in an increased susceptibility to develop neurodegenerative diseases. Additionally, as circadian rhythms and memory are intertwined, such rhythmic disturbances influence memory formation and recall. Besides, cell cycle events exhibit a remarkable oscillatory system, which is downstream of the circadian phenomena. The linkage between the molecular machinery of the cell cycle and complex fundamental regulatory proteins emphasizes the conjectural regulatory role of cell cycle components in neurodegenerative disorders such as Alzheimer’s disease. Among the mechanisms intervening long before the signs of the disease appear, the disturbances of the circadian cycle, as well as the alteration of the machinery of the cell cycle and impaired neurogenesis, must hold our interest. Therefore, in the present review, we propose to discuss the underlying mechanisms of action of melatonin in regulating the circadian rhythm, cell cycle components and adult neurogenesis in the context of AD pathogenesis with the view that it might further assist to identify new therapeutic targets.

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Effects of melatonin supplementation on BDNF concentrations and depression: A systematic review and meta-analysis of randomized controlled trials

Cited by 10 publications

References 67 publications

The Effect of Melatonin Supplementation on Cancer-Related Fatigue during Chemotherapy Treatment of Breast Cancer Patients: A Double-Blind, Randomized Controlled Study

The Effect of Melatonin Supplementation on Cancer-Related Fatigue during Chemotherapy Treatment of Breast Cancer Patients: A Double-Blind, Randomized Controlled Study

Investigating the Role of BDNF in Insomnia: Current Insights

Melatonin as a Harmonizing Factor of Circadian Rhythms, Neuronal Cell Cycle and Neurogenesis: Additional Arguments for Its Therapeutic Use in Alzheimer’s Disease

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