Effects of melatonin on diclofenac sodium treated rat kidney: a stereological and histopathological study

Khoshvakhti, Habib; Yurt, Kıymet Kübra; Altunkaynak, B. Zühal; Türkmen, Aysın Pinar; Elibol, Ebru; Aydin, Işınsu; Kıvrak, Elfide Gizem; Onger, M E; Kaplan, Süleyman

doi:10.3109/0886022x.2015.1073556

Cited by 15 publications

(8 citation statements)

References 22 publications

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“…Similar changes have been recorded by many authors in other experimental models of renal cortex disorders. For instance, in toxic effect of Gibberellic Acid [78], in diclofenac effect on the kidney of the prenatally administered rats [79], and non-Steroidal Anti-Inflammatory drugs as diclofenac, [80] [81] [82], and Meloxicam and Ketoprofen [83].…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Cranberry Extracts against Oxidative Stress and DNA Damage Induced by Diclofenac Sodium in Kidney of Male Albino Rate

Hassan¹,

Sabry²,

Hussein³

2017

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This work aimed to find the effect of cranberry extract (75 and 150 mg/kg•b•w) and vit. C (1 g/kg•b•w orally) on renal toxicity induced by Diclofenac sodium in male albino rats. Treated rats with diclofenac sodium with a concentration 150 mg/kg•b•w, expressed a significant increase in several parameters includes, plasma total cholesterol, LDL-cholesterol, and triglyceride as well as renal nitric oxide (NO), tumor necrosis factor-alfa (TNF-α) and TBARS. In addition, a significant reduction in renal superoxide dismutase (SOD), GSH, catalase (CAT) and plasma HDL. The present results explain that, using cranberry extract and vit. C resulted in increasing the level of GSH, CAT and SOD as well as gene expression of renal SOD, CAT and IL-22 and reduce the level of TBARs significantly which led to preventing renal tissue damage. Our results also revealed that cranberry extract can protect DNA from damage as obtained from comet essay. TM-U was elevated in DCLF treated group when compared with normal. However cranberry extract was able to reduce this elevation in dose dependant manner. Histological features in H&E taken to different groups also mirrors this findings. DCLF causes many changes in renal tissue include infiltration by inflammatory cells, attenuated glomeruli, apoptosis in tubular epithelia. Keywords

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Section: Discussionmentioning

confidence: 99%

Protective Effect of Cranberry Extracts against Oxidative Stress and DNA Damage Induced by Diclofenac Sodium in Kidney of Male Albino Rate

Hassan¹,

Sabry²,

Hussein³

2017

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“…Most stereological investigations on the kidney have been carried out on laboratory animals such as mouse (Arsenault et al, ; Walton et al, ; Nuñez et al, ) and rat (Şimşek et al, ; Khoshvakhti et al, ; Melchioretto et al, ; Seravalli et al, ), and also on other mammals such as nonhuman primates (Gubhaju and Black, ; Batchelder et al, ). However, apart from investigations on the kidney in pig (Cibulskyte et al, ; Karstoft et al, ; Lødrup et al, ,b), sheep (Bains et al, ; Wintour et al, ) and horse (Bolat et al, ), the morphometric features of kidney of other domestic animals have not been thoroughly investigated using stereology.…”

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confidence: 99%

Cat Kidney Glomeruli and Tubules Evaluated by Design‐Based Stereology

Sadeghinezhad

Nyengaard

2019

The Anatomical Record

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Renal function is related to its structure and three‐dimensional structural parameters correlate better with the kidney function than two‐dimensional structural parameters. Stereology is the current gold‐standard technique for the morphometrical evaluation of kidney structures. This study describes morphometric features of the kidney of the cat using design‐based stereological techniques aimed to introduce the cat as a translational model in nephrology and provide basic findings for diagnosis and treatment of kidney diseases in this species. Left kidneys of four cats were included in the present study. The kidney volume, volume fraction of cortex and medulla, glomerular volume, glomerular mean volume, glomerular number, and proximal convoluted tubule (PCT) and distal convoluted tubule (DCT) length were estimated. The kidney volume was estimated to 11.4 ± 1.3 cm3. The volume fraction of cortex and medulla was 65.6 ± 2% and 34.2 ± 2%, respectively. The total number of glomeruli was estimated to be 186 ± 11 × 103 using the physical disector/fractionator method. The mean glomerular volume was estimated to be 1.54 ± 0.06 × 106 μm3 and the glomerular volume was covering 2.13 ± 0.34% of the whole kidney. The total length of PCT and DCT was estimated to be 2.26 ± 0.48 km and 505 ± 43 m, respectively. Our data might contribute to the knowledge of kidneys in mammals and provide a comparison with available data on human and other mammals. Anat Rec, 302:1846–1854, 2019. © 2019 American Association for Anatomy

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“…The major mechanisms for WR-induced renal toxicity were previously reported as glomerular hemorrhage and tubular dysfunction by obstruction due to RBC casts (Mendonca, Gupta, Valsan, & Tewari, 2017;Ozcan et al, 2012). Similar to Chana et al (2014) who revealed that KT induced acute kidney injury, another NSAID, diclofenac sodium, was found to induce the congestion in the blood vessels, the degeneration in nephrons, and the increase in the connective tissue in rat kidneys (Khoshvakhti et al, 2015). Thus, the combined treatment of KT and WR may be responsible for the accelerated progressive events of acute kidney injury obtained in the current study.…”

Section: Discussionmentioning

confidence: 64%

Ketorolac- and warfarin-induced renal toxicity: ultrastructural and biochemical study

Othman

Abdel-Ghaffar

Mahmoud

2019

JoBAZ

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Background: Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely used drug classes worldwide. Although, these drugs have a potent analgesic and anti-inflammatory effects associated with nephrotoxicity. Factors such as advanced age and comorbidities may contribute to increase the risk of NSAID-related nephrotoxicity. The current study was designed to study the dual effect of non-NSAIDs and anticoagulants on the rat kidney. Methods: Thirty-two adult male albino rats were divided into four groups (n = 8): first, served as the control group which was orally administered with distilled water; second, served as the ketorolac (KT) group which received a daily intramuscular injection of ketorolac tromethamine (3 mg/kg/day); third, served as the warfarin (WR) group which was orally administered with racemic warfarin (0.3 mg/kg/day); and fourth, served as the combined (KT/WR) group which received an oral administration of WR (0.3 mg/kg/day) followed by an intramuscular injection of KT (3 mg/kg/day). After six consecutive days of daily treatment, all animals were sacrificed and their blood and tissue samples were collected.Results: A significant decrease in serum level of creatinine was observed in WR-and KT/WR-treated groups. However, urea increased significantly in the serum of the combined group, KT/WR. Furthermore, both WRand KT/WR-treated groups showed a significant increase in malondialdyhed (MDA) level; however, WR treatment induced a significant decrease in reduced glutathione (GSH) level. The total antioxidant capacity (TAC) of rat kidney showed a significant decrease in all treated groups. Electron microscopic investigations of kidney cortex localized variable degrees of focal degeneration, vacuolation, and vascular congestion in KTand WR-treated groups that are more vigorously attacking the cortical tissues in KT/WR-treated rats. Conclusions: We can conclude that the combined therapy of anti-inflammatory and anticoagulant drugs must be avoided or at least minimized, particularly in the elderly people, who mostly had other complications, in order to avoid the severe side effects on kidney structure and function.

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Effects of melatonin on diclofenac sodium treated rat kidney: a stereological and histopathological study

Abstract: We suggested that DS might lead to adverse effects in the kidneys of the rats that are prenatally subjected to this drug. Fortunately, these adverse effects can be prevented by the melatonin supplementation.

Cited by 15 publications

References 22 publications

Protective Effect of Cranberry Extracts against Oxidative Stress and DNA Damage Induced by Diclofenac Sodium in Kidney of Male Albino Rate

Protective Effect of Cranberry Extracts against Oxidative Stress and DNA Damage Induced by Diclofenac Sodium in Kidney of Male Albino Rate

Cat Kidney Glomeruli and Tubules Evaluated by Design‐Based Stereology

Ketorolac- and warfarin-induced renal toxicity: ultrastructural and biochemical study

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