Effects of Melatonin on Blood Pressure, Endothelial Function and Vascular Stiffness in Patients With Metabolic Syndrome and Sleep Disorders

Недогода, С. В.; Смирнова, В. О.; Barykina, I. N.; Саласюк, А. С.; Хрипаева, В. Ю.; Палашкин, Р. В.; Попова, Е. А.

doi:10.18705/1607-419x-2017-23-2-150-159

Cited by 10 publications

(6 citation statements)

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“…The normal physiological activity of the cardiovascular system (CVS) is regulated neutralizing free radicals, improving cholesterol clearance, and inhibiting lipid peroxidation [Nedogoda et al, 2017].…”

Section: Melatonin and The Cardiovascular Systemmentioning

confidence: 99%

The Effect of Melatonin on Metabolism and the Sleep-Wake Cycle

Kurdiukova,

Gasanbekov,

Pavlov

et al. 2024

RDLUZ

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The aim of this study was to investigate the influence of melatonin on metabolism and the implementation of the sleep-wake cycle. Methodology. Publications for this review were collected from PubMed, MedLine, and Google Scholar databases. Results. Melatonin is the main hormone that communicates the main circadian clock, located in the suprachiasmatic nucleus of the hypothalamus, and the peripheral biological clock located in brain cells and other organs. Melatonin production is related to day and night cycles, with peak production of the hormone occurring at night. Considering the pathophysiological mechanisms triggered by melatonin deficiency, the question reasonably arises about the possibilities of treating metabolic disorders (including type 2 diabetes), cardiovascular pathology and sleep disorders with melatonin preparations. Domestic and foreign publications provide reports of the clinically successful use of such drugs to improve sleep quality, increase sensitivity to glucose, lower blood pressure, reduce myocardial ischemia, and improve anthropometric parameters. All this makes melatonin a promising drug for managing cardiovascular risks against the background of metabolic disorders.

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Section: Melatonin and The Cardiovascular Systemmentioning

confidence: 99%

The Effect of Melatonin on Metabolism and the Sleep-Wake Cycle

Kurdiukova,

Gasanbekov,

Pavlov

et al. 2024

RDLUZ

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“…В исследовании, включившем 238 человек с метаболическим синдромом, артериальной гипертензией и нарушениями сна, были показаны эффективность, безопасность и удобство применения комбинации мелатонина (2 мг, таблетки с пролонгированным высвобождением) и метформина (2000 мг/сут). При оценке динамики суточного профиля артериального давления обратили на себя внимание изменения, произошедшие с таким показателем, как степень ночного снижения артериального давления (p<0,05, различие между группами с приемом метформина и комбинации метформина и мелатонина), являющимся важным предиктором кардиоваскулярного риска [75]. На данный момент требуются дальнейшие контролируемые исследования для лучшего понимания терапевтической ценности мелатонина в лечении экзогенно-конституционального ожирения и сравнения эффективности разных режимов лечения мелатонином.…”

Section: перспективы применения мелатонина при экзогенно-конституциональном ожиренииunclassified

The importance of melatonin in the regulation of metabolism, eating behavior, sleep, and the prospects for the use of melatonin drugs for obesity treatment

et al. 2021

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Melatonin is a special hormone that act as an internal synchronizer of circadian rhythms, the organism physiology and behavior to the environmental day and night and seasons of the year. The present urban society and the industrial production processes as organized should be considered, as both depend on the presence of indoor lights during the night and include the profuse use of electronic devices whose screens are rich in blue wavelength light. Light during the night delays the beginning of the secretory episode of melatonin and blunts its peak, causing chronic hypomelatoninemia. Hypomelatonemia, that causes deprivation of sleep and eating behavior disorders, along with low physical activity, can be the reason of the obesity, «non-infectious epidemic of the 21st century». According to this, the use of melatonin drugs for obesity treatment can be effective. Further prospective, controlled, randomized trials in this area are required to confirm this hypothesis.

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“…Между тем, установление особенностей микроциркуляторных нарушений у больных в восстановительном периоде после ишемического инсульта позволяет рекомендовать препараты, улучшающие приток артериальной крови к тканям, снижающие сосудистый спазм, а также массаж, физиотерапию, рефлексотерапию, лечебную физкультуру [53]. Добавление мелатонина к традиционной терапии метаболического синдрома пациентам с нарушениями сна позволяет улучшить функцию эндотелиальных клеток, снизить жесткость сосудов и нормализовать артериальное давление [54]. Показано также, что комбинированная антигипертензивная терапия антагонистом кальция и ингибитором ангиотензинпревращающего фермента увеличивает расчетный сосудистый возраст пациентов в среднем на девять лет [55,56].…”

Section: диагностика профилактика и коррекция сосудистых расстройствunclassified

Maladaptive neuropathological syndrome of blood vessel aging

Artemenkov

2019

Russ J Cardiol

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This article discusses the relationship between maladaptation and blood vessel aging. The work shows that upright posture created an additional load on the circulatory system, and the lifestyle of a modern human is an additional risk factor of cardiovascular diseases. It has been suggested that a disorder of the nervous regulation of vascular tone is the main etiopathogenetic mechanism of morphofunctional changes in blood vessels and their aging. We discussed the statute that vascular reactions in humans is based on the formation of a maladaptive circuit in the cerebral cortex, consisting of a matrix of motor, sensory and associative cortical neurons involved in the maladaptive process. This hypothesis is based on the fact that any irritations entering the cerebral cortex from the periphery (thermal, pain, and others) cause cortical-vascular reflex reactions that change their tonic activity. Based on this principle, a model of vascular aging is further constructed, which is based on the maladaptive damage to all layers of the vascular wall (intima, media and adventitia). The opinion is expressed about the need for early diagnosis and prevention of vascular disorders to maintain human health. In conclusion, it is concluded that if the age of a person is really determined by the age of his blood vessels, then in order to achieve active longevity it is necessary to normalize the relationship in the adaptation-maladaptation-environment. Detailed study of hypertrophy and calcification of blood vessels is needed, since aging always reveals vascular wall thickening and stiffness increase.

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Effects of Melatonin on Blood Pressure, Endothelial Function and Vascular Stiffness in Patients With Metabolic Syndrome and Sleep Disorders

Cited by 10 publications

References 0 publications

The Effect of Melatonin on Metabolism and the Sleep-Wake Cycle

The Effect of Melatonin on Metabolism and the Sleep-Wake Cycle

The importance of melatonin in the regulation of metabolism, eating behavior, sleep, and the prospects for the use of melatonin drugs for obesity treatment

Maladaptive neuropathological syndrome of blood vessel aging

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